Survival of Vaccine-Induced Human Milk SARS-CoV-2 IgG, IgA and SIgA Immunoglobulins across Simulated Human Infant Gastrointestinal Digestion인간 유아 위장 소화를 통한 백신 유도 모유 SARS-CoV-2 IgG, IgA 및 SIgA 면역글로불린의 생존Article Published on 2022-08-172022-09-12 Journal: Nutrients [Category] SARS, 진단, [키워드] adenovirus-based antibody Breastfeeding breastmilk COVID-19 COVID-19 pandemic Degradation digestion dose evaluated Evidence Gastrointestinal GI Tract help Human human milk IgA IgA antibody IgG Immunoglobulin immunoglobulins in vitro Inconclusive Infant information intestinal lactating milk mother mRNA-based vaccine natural infection passive immunity persistence Pfizer/BioNTech produced PROTECT protective role protocol recent reduced reduction SARS-CoV-2 SARS-CoV-2 IgG secretory IgA SIgA the SARS-CoV-2 virus the spike protein the vaccine transfer vaccination Vaccine women [DOI] 10.3390/nu14163368 PMC 바로가기 [Article Type] Article
Neutralization activity of sera/IgG preparations from fully BNT162b2 vaccinated individuals against SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Kappa variantsSARS-CoV-2 Alpha, Beta, Gamma, Delta 및 Kappa 변이체에 대한 BNT162b2 백신을 완전히 접종한 개인의 혈청/IgG 제제 중화 활성Article Published on 2022-08-082022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료제, [키워드] (alpha administration Alpha antiviral activity approach Beta BNT162b2 BNT162b2 vaccine caused change COVID-19 pandemic Delta delta variant Effectiveness examined fraction Gamma General Hospital IgG individual Influenza influenza vaccines Japan Kumamoto long-lasting Moderation mRNA mRNA-based vaccine mutable Neutralizing activity of BNT162b2 pandemic Pathogens Prospective Study purified reduced reduction respond SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant sera vaccinated individual Vaccine variant variants wild-type SARS-CoV-2 Wuhan [DOI] 10.1038/s41598-022-17071-9 PMC 바로가기 [Article Type] Article
Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapiesB 세포 고갈 요법을받는 다발성 경화증 환자에서 COVID-19 예방 접종에 대한 강력한 T 세포 활성화Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response Adaptive immunity analyzed anti-CD20 anti-CD20 therapy antibodies antibody production B-cell binding blocking activity BNT162b2 Cellular immune response cellular response Cohort competent Complication condition controls coronavirus COVID-19 COVID-19 vaccination depleting disease driven by form forms hACE2 healthy control humoral Humoral and cellular responses IFNγ IgG antibodies IgG antibody IL-2 immunocompromised individuals Immunotherapy implication individual individuals Infection investigation mRNA mRNA-1273 mRNA-based mRNA-based vaccine multiple sclerosis no difference Ocrelizumab Patient patients proliferation RBD receiving Receptor binding domain recognizing reduced regimen relapsing respiratory rituximab SARS-CoV-2 Seroconversion seroconversion rate severe acute respiratory syndrome Coronavirus significantly significantly higher Spike protein Strong strong T-cell susceptible T-cell T-cell activation T-cell Response therapy vaccination Vaccine design virus infection [DOI] 10.3389/fimmu.2022.926318 PMC 바로가기 [Article Type] Article
Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases자가면역 류마티스 질환 환자에서 ChAdOx1 nCoV-19/AZD1222 및 mRNA-1273 백신의 면역원성을 해독하기 위한 단일 세포 RNA 시퀀싱Article Published on 2022-08-012022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Analysis analyzed anti-rheumatic medications anti-SARS-CoV-2 IgG antibodies Antigen presentation Arthritis Autoimmune AZD1222 CD16 CD4 ChAdOx1 COVID-19 COVID-19 vaccine database domain dose electrochemiluminescence immunoassay enriched pathway enrolled exhibited Gene Expression Omnibus GEO healthy controls HLA-DRA immunized inhibitor Interaction Janus kinase methotrexate MHC class Moderna monocyte mononuclear cell mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine Necrosis Oxford-AstraZeneca participant pathway Patient patients PBMC PBMCs Peripheral blood predominant quantified receiving rheumatic disease RNA sequencing scRNA-seq serum IgG antibody Single-cell RNA sequencing the SARS-CoV-2 vaccination Vaccine [DOI] 10.3389/fimmu.2022.920865 PMC 바로가기 [Article Type] Article
Messenger ribonucleic acid vaccines against infectious diseases: current concepts and future prospectsReview article Published on 2022-08-012022-10-05 Journal: Current opinion in immunology [Category] 비임상, [키워드] acute respiratory syndrome antigens clinical development Clinical studies complex coronavirus effective Infectious disease messenger mRNA-based vaccine over pandemic pathogen Perspective platform safety profile single vaccine Vaccine [DOI] 10.1016/j.coi.2022.102214 [Article Type] Review article
A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variantsDelta × Omicron 하이브리드 mRNA 백신의 추가 용량은 Omicron 및 기타 SARS-CoV-2 변이체에 대한 광범위 중화 항체를 생성했습니다.Article Published on 2022-07-072022-09-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antigenic approach booster dose CD8+ conserved COVID-19 cross-protective Cross-protectivity Delta Delta variants develop Efficacy elicited epitope feasible hybrid Hybrid vaccine Immune escape immunized Inclusion mice mRNA vaccine mRNA-based vaccine Mutation naïve Neutralizing Neutralizing antibodies neutralizing antibody new SARS-CoV-2 Next generation vaccine omicron Omicron vaccine produced RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants shown specific neutralizing antibodies T cell T cell response T cell responses tested Transmission Vaccine Vaccine design Vaccines variant variants variants of concern VOCs wild type wild-type [DOI] 10.1186/s12929-022-00830-1 PMC 바로가기 [Article Type] Article
Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.S Research Published on 2022-07-062022-10-05 Journal: NPJ Vaccines [Category] 유전자 메커니즘, [키워드] Ad26.COV2.S antibody BNT162b2 booster Comparative analysis declined delta variant domain drug elicited ELISA Emergency use authorization evaluated food human immune response humoral Humoral response IFN immune response Immunity individual initial magnitude mRNA-1273 mRNA-based vaccine Neutralization assay Observational cohort study SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 virus Support T cell response vaccination Vaccines variants waned wild-type strain γ ELISPOT assay [DOI] 10.1038/s41541-022-00504-x [Article Type] Research
Brief Research Report: Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination간략한 연구 보고서: mRNA 기반 COVID-19 백신 접종을 통한 암 면역 요법에 대한 오래 지속되는 응답자의 항 SARS-CoV-2 면역Article Published on 2022-07-052022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analysed antibodies antibody Antibody Response antiviral immune response BNT162b2 Cancer Cancer immunotherapy Cohort Complete Control control group COVID COVID-19 COVID-19 vaccination develop ELISA generate group healthy control IFN-γ IgG titer IgGs immune Immune checkpoint inhibitor immune checkpoint inhibitors (ICIs) immune response Immunotherapy increase in independent induce Long long lasting responders long-lasting median mRNA-based COVID-19 vaccine mRNA-based vaccine mRNA-based vaccines NAb neutralizing antibody neutralizing capacity Patient patients treated prime-boost regimen receiving regimen respond Responder responders responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG serum antibodies significantly increased solid tumors statistically significant T cell response T cell responses T cells the healthy the patient treated vaccination Vaccine virus [DOI] 10.3389/fimmu.2022.908108 PMC 바로가기 [Article Type] Article
Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다Observational Study Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] Against age antagonist antagonists anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody concentrations Antibody titer Antibody titers Biologicals Blood blood sampling bowel Characteristics clinical Clinical characteristics Combination completion Concentration COVID-19 Crohn's disease defined demonstrated detectable disease Effect elapsed geometric geometric mean IBD IgG IgG antibodies IgG antibody IgG antibody titer IgG antibody titers immune response immunoassay immunomodulating Immunosuppressive medication immunosuppressive medications increased risk independent independent of Inflammatory Inflammatory bowel disease medication Microparticle monotherapy Most patients mRNA mRNA vaccines mRNA-based vaccine mRNA-based vaccines Multivariable models Patient patient age patients patients treated prospective observational cohort quantitative determination RBD receive receiving Receptor-binding domain regimen response S1 subunit sampling SARS-CoV-2 SARS-COV-2 infection Seroconversion serological response significantly lower Spike protein the receptor-binding domain the S1 subunit the spike protein titer TNF-α-antagonists treated Treatment Tumor ulcerative colitis vaccination Vaccine vector was used were measured were recorded [DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study
B-cell responses to vaccination with BNT162b2 and mRNA-1273 6 months after second doseBNT162b2 및 mRNA-1273 2차 접종 6개월 후 백신 접종에 대한 B 세포 반응Article Published on 2022-07-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 age anti-SARS-CoV-2 antibody antibody association B-cell B-cell response binding binding antibody unit BNT162b2 characterized clinical consequence correlation COVID-19 dose examined Frame greater IgA IgG immune response Immunity Level majority marker mRNA-1273 mRNA-based vaccine NAb Neutralization assay neutralizing antibody optical participant Participants Prevalence reactive response SARS-CoV-2 second dose second vaccination Sex significantly the median titre vaccination [DOI] 10.1016/j.cmi.2022.02.028 PMC 바로가기 [Article Type] Article