mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cellsArticle Published on 2022-09-072022-11-16 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] antibody antigen-presenting cells appear B cell biodistribution Cancer Cancer vaccine CD8 T cell changes in Clinical studies design-of-experiments methodology effective extrahepatic delivery histopathological Immune cell immune cell populations Immunity immunization Immunotherapy induce interferon liver LNP mechanism methodology mRNA mRNA expression non-human primate phagocyte provide response responses SARS-CoV-2 spleen stimulatory systemic T cell T cell response the vaccine Type vaccination Vaccine [DOI] 10.1016/j.ymthe.2022.07.007 PMC 바로가기
Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1α in SARS-Cov-2 infected patientsArticle Published on 2022-09-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alteration Analysis Clinical data condition COVID-19 COVID-19 infection COVID-19 patients cytokine Cytokine storm demonstrated determine evaluated expression extracted RNA Gene Expression gene expression level gene expression pattern healthy individual HIF-1α individuals induce infected patient Infection influence Laboratory material molecular mRNA expression Other pandemic PAPP-A Patient patients with COVID-19 Peripheral blood positive correlation pro-inflammatory molecules Prognosis Real-time PCR SARS-CoV-2 Severe patient STC-2. stimulate target was used [DOI] 10.1007/s11033-022-07710-9 PMC 바로가기
Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19중증 유행성 인플루엔자 A(H1N1) 및 COVID-19 환자에서 IFITM1 및 IFITM3의 차등 백혈구 발현Article Published on 2022-08-012022-09-11 Journal: Journal of interferon & cytokine research : the of [Category] 바이오마커, 신종인플루엔자, [키워드] addressed characteristic Clinical characteristics Clinical outcome clinical outcomes Cohort Comparisons coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 disease disease susceptibility downregulation Endosomes evaluated Evidence expression healthy control healthy controls High-dose humans IFITM IFITM1 IFITM3 individual Infection Influenza influenza A influenza A(H1N1) leukocyte leukocytes lung Lungs membrane fusion mice Mortality mRNA expression murine model nucleotide outcome outcomes pandemic pandemic influenza participant Patient Pneumonia Protective Protein respiratory respiratory infections Single nucleotide polymorphism single nucleotide polymorphisms susceptibility transmembrane underlying disease Viral viral respiratory infection viral respiratory infections virus viruses [DOI] 10.1089/jir.2022.0036 PMC 바로가기 [Article Type] Article
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses [DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article
Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release인간 폐 섬유아세포는 증가된 IL6 유전자 발현 및 방출을 통해 유도된 염증 기억을 나타냅니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACTA2 affected Analysis ANOVA Cell cell line cell lines chronic respiratory disease chronic respiratory diseases Col1a1 contribute COVID-19 determine determined by downregulated ELISA fibroblast fibroblasts fibrosis followed by Gene Expression Human human lung IL1B IL2 IL6 IL8 Immunity Increased induced Inflammatory inflammatory memory Inflammatory response inhibition inhibitor interleukin-6 investigated involved lung memory Mmp8 mRNA expression multiple groups NF-κB not affect pathway Pathways Poly (I:C) POSTN predict qRT-PCR Release respiratory diseases respond SARS-CoV-2 SARS-CoV-2 spike protein significantly significantly increased Simultaneous Simultaneous treatment Spike protein statistical significance subsequent TGFB1 TLR3 TNFα trained immunity treated Treatment two-way ANOVA viral infection was determined were measured were used Withdrawal [DOI] 10.3389/fimmu.2022.921728 PMC 바로가기 [Article Type] Article
Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] acute exacerbation alleviate benefit Body Borg chronic obstructive control group COPD Dyspnoea Effect exercise Exercise capacity exercise intolerance exhibited Follow-up groups Guidance increase in indication Intervention mechanism mMRC mRNA expression no difference oxidative stress parameter Patient patients Protein pulmonary disease Pulmonary function pulmonary rehabilitation randomized clinical trial randomly divided reduce reduced rehabilitation significantly increased Spinal cord injury Stepper stroke Symptom Total undergo walking distance [DOI] 10.1038/s41598-022-15466-2 [Article Type] Research
Contribution of CD4+ T cell-mediated inflammation to diarrhea in patients with COVID-19COVID-19 환자의 설사에 대한 CD4+ T 세포 매개 염증의 기여Article Published on 2022-07-012022-09-11 Journal: International Journal of Infectious Diseases [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] ACE2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association CD4/CD8 CD4+ CD4+ T cell CD4+ T cells Cell cells chemokine chemokines Colon contribute correlation analyses Correlation analysis COVID-19 CXCL10 CXCL11 CXCR3 determine diarrhea distribution expressed expression groups Gut identify Inflammation inflammation sites lymphocyte Lymphocyte subset Lymphocyte subsets mechanism Migration mRNA mRNA expression Necrosis no difference Patient patients with COVID-19 percentage percentages performed protease protein levels receptor SARS-CoV-2 SARS-COV-2 infection Serine serine 2 significant difference T cell T cells T-box TNFα transmembrane transmembrane protease serine 2 Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha [DOI] 10.1016/j.ijid.2022.04.006 PMC 바로가기 [Article Type] Article
Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial CellsCOVID-19 환자의 순환 엑소좀은 내피 세포에서 NLRP3 인플라마좀을 유발합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation of caspase-1 acute respiratory syndrome acute respiratory syndrome coronavirus augmentation blood flow cargo caspase caspase-1 Cell Circulatory Coagulation Coagulopathy combating Control coronavirus coronavirus 2 COVID-19 Culture culture medium Cytokine storm demonstrated drug endothelial Endothelial cell endothelial cells ENhance examined Exosome Exosomes exposure to extracellular vesicle Extracellular vesicles Health health problem healthy donors help highlight IL-1β Immunopathogenesis induce Infection Inflammasome Inflammation Inflammatory response inhibit interleukin interleukin-1β investigator liver mechanism medium Mild Mild disease molecular molecular mechanism mRNA expression Multiple organ damage NLRP3 NLRP3 inflammasome opens organ organ damage Pathogenesis Patient plasma predicted Prevent respiratory resting resulting SARS-CoV-2 SARS-COV-2 infection secretion Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients significantly the vaccine Therapies Trigger Vaccine Venous Thromboembolism with mild disease [DOI] 10.1128/mbio.00951-22 PMC 바로가기 [Article Type] Article
Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol receptor transcription in the lungs and colon of male rats17β-estradiol이 수컷 쥐의 폐와 결장에서 ACE2, ADAM17, TMPRSS2 및 estradiol 수용체 전사의 일일 패턴에 미치는 영향Article Published on 2022-06-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol ACE2 ACE2 mRNA ADAM17 Administered administration amplitude analysed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Bmal1 Cell CLOCK Colon component components dosage Effect enzyme ESR1 ESR2 expression Features female GPER1 greater implicated lung Lungs male men molecules mRNA expression pathway pharmacological progression receptor Regulation Renin renin-angiotensin system rhythm sampling SARS-CoV-2 SARS-CoV-2 entry shown survival rate the SARS-CoV-2 the timing therapy tissue TMPRSS2 Transcription Treatment was performed women [DOI] 10.1371/journal.pone.0270609 PMC 바로가기 [Article Type] Article
C1R, CCL2, and TNFRSF1A Genes in Coronavirus Disease-COVID-19 Pathway Serve as Novel Molecular Biomarkers of GBM Prognosis and Immune Infiltration코로나바이러스 질병-COVID-19 경로의 C1R, CCL2 및 TNFRSF1A 유전자는 GBM 예후 및 면역 침투의 새로운 분자 바이오마커 역할을 합니다Article Published on 2022-06-182022-09-11 Journal: Disease Markers [Category] MERS, 바이오마커, 진단, [키워드] Analysis Bioinformatics analysis Biomarker Brain Brain tumor CCL2 Cell coronavirus coronavirus disease correlation database DEGs differentially expressed gene Early detection experiment expression expression level expression levels glioblastoma multiforme identify Immune cell Immune cell infiltration immune cells immune infiltration immune response indicated infiltration involved KEGG molecular mRNA expression novel pathway Pathways Patient patients prevalent Prognosis proportion protein-protein interaction significant difference significantly survival tissue TNFRSF1A Treatment Tumor used data [DOI] 10.1155/2022/8602068 PMC 바로가기 [Article Type] Article