Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins30229 SARS-CoV-2 균주의 상위 10개 동의어가 아닌 변이체가 단백질에 미치는 영향 예측Article Published on 2022-01-062022-09-11 Journal: F1000Research [Category] SARS, 변종, [키워드] addition affecting Amino acid amino acid residue Analysis analyzed bioinformatics cause co-mutation computational studies Computational study consequence COVID-19 D614G Deleterious Effect Frequency functions highest Impact in vitro in vivo Multiple studies Mutation N protein N501Y nine nonsynonymous mutation nonsynonymous mutation. Nonsynonymous mutations nonsynonymous variant Nsp12 nsp5 ORF1 ORF1a ORF1b ORF3 ORF3a outbreak P323L pathogen prediction Protein protein structure Proteins Q57H reported S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequences SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strain SARS-CoV-2 virus stability Structure the SARS-CoV-2 genome wild type Wuhan Wuhan, China [DOI] 10.12688/f1000research.72904.2 PMC 바로가기 [Article Type] Article
Left ventricular global longitudinal strain imaging in identifying subclinical myocardial dysfunction among covid-19 survivorscovid-19 생존자 중 무증상 심근 기능 장애를 식별하는 좌심실 전역 종 방향 변형 영상Article Published on 2022-01-012022-09-11 Journal: Indian heart journal [Category] SARS, 치료기술, [키워드] 2D-echocardiography analysed cardiac cardiovascular disease cardiovascular diseases caused Complication computerised tomography consecutive patient contributing to COVID-19 COVID-19 disease COVID-19 pandemic Critical defined detect discharge disease disease severity dysfunction echocardiography EF Ejection fraction GLS had no high mortality left LV dysfunction LV dysfunction. magnetic resonance imaging manifestation Mild mild to moderate moderate morbidity Mortality MRI Multiple studies multiple study Myocardial dysfunction myocarditis pandemic Patient patients reduced Respiratory illness SARS-CoV-2 virus severe COVID-19 severe respiratory illness severity study cohort survivor Survivors the disease variety ventricular viral infection [DOI] 10.1016/j.ihj.2021.12.007 PMC 바로가기 [Article Type] Article
Identifying Putative Causal Links between MicroRNAs and Severe COVID-19 Using Mendelian Randomization멘델식 무작위화를 사용하여 MicroRNA와 심각한 COVID-19 사이의 추정 인과 관계 식별Article Published on 2021-12-112022-09-11 Journal: Cells [Category] SARS, 바이오마커, [키워드] approaches assessment Biomarker Biomarkers canonical Causal causal relationship Causality caused circulating circulating miRNA circulating miRNAs COVID-19 COVID-19 case COVID-19 cases COVID-19 severity death diagnose early treatment Effect eQTL evaluated expression data group GWAS summary statistics help identify identifying imperative IMPROVE independent investigated measure mendelian randomization microRNA miRNA miRNA biomarker miRNA expression miRNAs Multiple Multiple studies outcomes pandemic phenotype Prognosis provide retrieved risk Risk assessment risk assessments SARS-CoV-2 severe cases severe COVID-19 shown unique with COVID-19 [DOI] 10.3390/cells10123504 PMC 바로가기 [Article Type] Article
Detection of IFNγ-Secreting CD4 + and CD8 + Memory T Cells in COVID-19 Convalescents after Stimulation of Peripheral Blood Mononuclear Cells with Live SARS-CoV-2살아있는 SARS-COV-2를 갖는 말초 혈액 단핵 세포의 자극 후 COVID-19 COVALESCERS에서 IFNγ- 분비 CD4 + 및 CD8 + 메모리 T 세포의 검출Brief Report Published on 2021-07-292022-09-10 Journal: Viruses [Category] SARS, 치료기술, [키워드] causative agent CCR7 CD4 CD45 CD45RA CD8 Cell Cellular immune response cellular immune responses Characteristics circulating circulation collected convalescent coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 convalescents COVID-19 pandemic Cytotoxic T cell Cytotoxic T cells detection effector memory Epitopes flow cytometry Human IFNγ Immune cell immune cells immune responses Immunity information intracellular cytokine staining live SARS-CoV-2 memory T-cell response memory T-cell responses Multiple Multiple studies natural infection New New coronavirus new coronavirus SARS-CoV-2 PBMC PBMCs peptide peptide pool peptide pools peptides peripheral persistence phenotype pool Quantitative SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines significant level Stimulation sucrose T cell T cells T-cell T-cell epitopes T-cell immunity T-cell memory T-cell responses T-helper long-lived immunity the disease These data Viral Viral proteins [DOI] 10.3390/v13081490 PMC 바로가기 [Article Type] Brief Report
The Clinical Course of COVID-19 Pneumonia in a 19-Year-Old Man on Intravenous Immunoglobulin Replacement Therapy for X-Linked AgammaglobulinemiaX-연관 무감마글로불린혈증에 대한 정맥 면역글로불린 대체 요법을 받은 19세 남성의 코로나19 폐렴 임상 경과Case Reports Published on 2021-02-222022-09-11 Journal: The American journal of case reports [Category] MERS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission agammaglobulinemia Azithromycin bronchiectasis clinical Clinical course clinical evaluation complications coronavirus coronavirus disease Coronavirus disease 2019 cough Course COVID-19 COVID-19 pneumonia Critically ill critically ill patients diarrhea dose Fever hospital immune Immunity Immunoglobulin immunologically infected individual Infection intensive care intensive care unit admission Intravenous immunoglobulin IVIG Man management Mild Multiple Multiple studies no symptoms outcome outcomes oxygen oxygen supplementation Patient piperacillin piperacillin/tazobactam Pneumonia productive cough Prophylactic receiving replacement replacement therapy reported resolved respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 severity Shortness of breath Steroids suggested Symptom tazobactam therapy Treatment Variation weakened X-linked agammaglobulinemia XLA [DOI] 10.12659/AJCR.929447 PMC 바로가기 [Article Type] Case Reports
De novo design of new chemical entities for SARS-CoV-2 using artificial intelligence인공 지능을 사용하여 SARS-CoV-2에 대한 새로운 화학 물질의 새로운 설계Research Article Published on 2021-02-162022-08-31 Journal: Future Medicinal Chemistry [Category] MERS, SARS, 신약개발, 치료제, [키워드] 3CL 3CL Protease affected artificial intelligence candidate Compound COVID-19 de novo deep learning Economy Final focus Health inhibiting material Multiple Multiple studies Novel coronavirus novel coronavirus SARS-CoV-2 physicochemical Predictive model protease protease inhibitors Protein reinforcement reinforcement learning SARS-CoV-2 small molecule Small molecules target protein transfer Virtual screening virus replication were used [DOI] 10.4155/fmc-2020-0262 PMC 바로가기 [Article Type] Research Article
Lack of viable severe acute respiratory coronavirus virus 2 (SARS-CoV-2) among PCR-positive air samples from hospital rooms and community isolation facilities병실 및 지역사회 격리 시설에서 채취한 PCR 양성 공기 샘플 중 생존 가능한 중증 급성 호흡기 코로나바이러스 2(SARS-CoV-2) 부족Observational Study Published on 2021-01-252022-09-10 Journal: Infection Control and Hospital Epidemiology [Category] MERS, SARS, 임상, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol Aerosols Air sampling airborne blind blind passages Chain Reaction collected Community coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cubic Culture determine diameter hospital Intervention Isolation Isolation room media methodology Multiple Multiple studies nucleic acid ORF1 ORF1ab gene pandemic passages PCR-positive polymerase chain polymerase chain reaction positive qRT-PCR Quantitative Quantitative real-time polymerase chain reaction ranged reported respiratory respiratory aerosol respiratory aerosols Respiratory Coronavirus RNA concentration Sample SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus shedding small sample size tested Transmission understanding viability Viral viral culture Viral RNA virus virus culture virus cultures water water vapor [DOI] 10.1017/ice.2021.8 PMC 바로가기 [Article Type] Observational Study
Rapid single cell evaluation of human disease and disorder targets using REVEAL: SingleCell™Database Published on 2021-01-062022-10-28 Journal: BMC Genomics [Category] COVID-19, [키워드] ACE2 Array native database Atla caused Cell cell type annotation cells cellular co-expression complex coronavirus COVID-19 COVID-19 pandemic Data storage and retrieval database dataset datasets described develop diagnostics disorder evaluate evaluated Evaluating exacerbated example explain expressed expressing expression expression profile facilitate Gene Expression Genes Hierarchical Human human cell human disease hypothese hypotheses include individual cell infected patient Infection infections Infectious disease Information extraction involved less manuscript Metadata Multiple studies oncology Ontology organs platform populations Precision prevalent Protein question Rapid resource returned SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 research SARS-CoV-2 virus SciDB selected Sequencing Single Cell Single cell analysis single-cell single-cell dataset spread of COVID-19 supplementary material target target gene targets threshold tissue TMPRSS2 utility Vaccine viral entry virulence virus worldwide pandemic [DOI] 10.1186/s12864-020-07300-8 PMC 바로가기 [Article Type] Database
Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface표면 성인 인간 결막, 윤부 및 각막 상피에서 SARS-CoV-2 진입 유전자의 동시 발현은 안구 표면을 통한 추가 진입 경로를 제안합니다Article Published on 2021-01-012022-09-10 Journal: The Ocular Surface [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] ACE2 ACE2 and TMPRSS2 expression ACE2 receptor Analysis Cell chromatin co-expression Conjunctiva conjunctival Cornea Corneal dataset embryonic ENhance epithelium expression pattern facilitate Factor fetal IFNg Immunohistochemical analysis Infection infection rate Inflammatory investigated loci molecular mechanism molecular mechanisms Multiple studies multiple study Ocular surface portal pro-inflammatory signal Propagation protease TMPRSS2 provide Result RNA SARS-CoV-2 SARS-CoV-2 entry Single Cell single-cell TMPRSS2 TMPRSS2 expression TNF transcriptional transmission route upregulation upstream Viral viral entry [DOI] 10.1016/j.jtos.2020.05.013 PMC 바로가기 [Article Type] Article
COVID-19 length of hospital stay: a systematic review and data synthesisResearch Article Published on 2020-09-032022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] absence Admission Applying approach Bed demand can be used Care China Community COVID-19 COVID-19 pandemic criteria died discharge discharged distribution eight equipment estimate Evidence explained generate health systems healthcare hospital hospitalisation ICU ICU capacity ICUs intensive care unit IQR Length of stay Local majority median median value Multiple studies pandemic Patient patients with COVID-19 performed provided ranged reported resource Result resulting sample sizes SARS-CoV-2 systematic review with COVID-19 [DOI] 10.1186/s12916-020-01726-3 PMC 바로가기 [Article Type] Research Article