Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndromeArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] analyzed Anti-viral anti-viral antibody antibody Antibody Response baseline chronic disease CMV cohorts COVID-19 EBV elevated fatigue healthy donor herpesvirus herpesvirus reactivation HERV HERV-K HHV6A HSV2 IgG immunoassay latent virus majority ME/CFS mechanisms multiplex myalgic encephalomyelitis/chronic fatigue syndrome. nuclear oral mucosa overlap Patient plasma Post-viral fatigue Reactivation retrovirus risk factor Saliva SARS-COV-2 infection shown significantly sustained Symptom syndrome systemically triggered unique viral infection virus virus [DOI] 10.3389/fimmu.2022.949787 PMC 바로가기
The Efficient and Practical virus Identification System with ENhanced Sensitivity for Solids (EPISENS-S): A rapid and cost-effective SARS-CoV-2 RNA detection method for routine wastewater surveillance고형물에 대한 감도가 향상된 효율적이고 실용적인 바이러스 식별 시스템(EPISENS-S): 일상적인 폐수 감시를 위한 빠르고 비용 효율적인 SARS-CoV-2 RNA 검출 방법Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] applicability centrifugation city collected Concentration confirmed COVID-19 case COVID-19 demonstrated Detection sensitivity efficient Epidemiology evaluated examined followed by heat heat-inactivated identification Japan magnitude Mild multiplex normalized pellet Pepper mild mottle virus plant primer Primers qPCR qPCR quantification qPCR. Quantification method quantified ranged reported reverse primer reverse primers RNA concentration RNA concentrations RNA extraction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity Solid subsequent Surveillance System target targets the SARS-CoV-2 Treatment virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.157101 PMC 바로가기 [Article Type] Article
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanismArticle Published on 2022-10-102022-11-15 Journal: Molecular Medicine [Category] 바이오마커, [키워드] Accuracy acute COVID-19 Angiogenesis AUC Biomarker Biomarkers Blood case-control study characterized Cohort COVID-19 Diagnosis diagnostics disease elevated Endoglin female Follow-up Health healthy control ICAM-1 immunoassay Inpatient Intervention investigated lack long-COVID machine machine learning marker median multiplex outpatients pathophysiological mechanism Patient patients Post-infection Sensitivity and specificity Sex significantly Specific subject Symptom targeted therapy therapeutic efficacy unique Vascular Vascular transformation. vasculature VCAM-1 VLA-4 [DOI] 10.1186/s10020-022-00548-8 PMC 바로가기
The Clinical and Genomic Epidemiology of Rhinovirus in Homeless Shelters-King County, WashingtonArticle Published on 2022-10-072022-11-15 Journal: The Journal of Infectious Diseases [Category] 유전자 메커니즘, 치료기술, [키워드] acute respiratory illness analyzed circulating clinical Community congregate setting coronavirus disease COVID-19 COVID-19 pandemic cross-sectional Enrollment Epidemiology genomic Genomic analysis highest homeless shelter Infection King measure multiplex nasal swabs pandemic participant people experiencing homelessness Prevalence prevalent questionnaire Respiratory illness respiratory pathogen respiratory viral respiratory viral infection respiratory viruses rhinovirus Rhinovirus. RT-PCR Sample sequenced sequenced samples serotype serotypes study period submitted subset Surveillance Symptoms tested Trial virus Washington [DOI] 10.1093/infdis/jiac239 PMC 바로가기
Multiplex Detection of Antibody Landscapes to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/Influenza/Common Human Coronaviruses Following Vaccination or Infection With SARS-CoV-2 and InfluenzaArticle Published on 2022-10-032022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory illness acute respiratory syndrome Adsorption analyzed antibody antibody immunity antibody landscape Antibody Response ARI Clinical presentations collected common human coronaviruses coronavirus coronavirus 2 cross-reactive antibody detection exhibited Human human coronavirus human coronaviruses in-depth analysis individual Infection Influenza influenza infection influenza vaccine influenza virus landscape Last multiplex multiplex detection. no interaction protective immunity public health threat representing respiratory respiratory infection response responses SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 vaccination Sensitivity and specificity sera serological evidence serum Spike protein vaccination Vaccine [DOI] 10.1093/cid/ciac472 PMC 바로가기
A compact, low-cost, and binary sensing (BiSense) platform for noise-free and self-validated impedimetric detection of COVID-19 infected patientsCOVID-19 감염 환자의 소음이 없고 자체 검증된 장애 감지를 위한 소형의 저비용 바이너리 감지(BiSense) 플랫폼Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료기술, 치료법, [키워드] acquisition added advancement Alpha Analysis approach Bi-potentiostat Biomarkers biosensor complex components COVID-19 infected patient creating Diagnosis electrical electrochemical biosensing electrode infections less matrix effect multiplex N-protein nasopharyngeal platform point-of-care Protein Quantitative Rapid Rapid tests reliability reported SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2. shelf swab samples variant was used [DOI] 10.1016/j.bios.2022.114459 PMC 바로가기 [Article Type] Article
Developing and validating SARS-CoV-2 assays for nonhuman primate surveillanceArticle Published on 2022-10-012022-11-15 Journal: Journal of medical primatology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Algorithm antibody antiviral antibodies assays center detect Developing diagnostic diagnostic testing algorithm. enzyme immunoassay Infection Laboratory multiplex NIH nine nucleocapsid over performed primate reactive Receptor binding domain RT-PCR SARS-CoV-2 SARS-COV-2 infection specificity Surveillance tested Viral RNA virus antigen [DOI] 10.1111/jmp.12604 PMC 바로가기
Longitudinal Systemic and Mucosal Immune Responses to SARS-CoV-2 InfectionArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome age Antibody Response binding antibody Blood breadth Control coronavirus coronavirus disease correlated correlation COVID-19 determine disease severity domain evaluated IgA IgM Immunity Immunoglobulin implication independent individuals Infection longitudinal mucosal mucosal immunity. multiplex nasal neutralization Neutralizing neutralizing response observation occurred Participants pseudovirus assay RBD RBD-specific IgG Receptor binding Reinfection respiratory respiratory sample response responses against SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion serum Spearman Stool systemic Transmission uninfected Vaccine was performed [DOI] 10.1093/infdis/jiac065 PMC 바로가기
Simultaneous Detection of RIG-1, MDA5, and IFIT-1 Expression Is a Convenient Tool for Evaluation of the Interferon-Mediated ResponseArticle Published on 2022-09-212022-11-15 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] A549 cell acute phase assumed both virus clinical Course cytosolic cytosolic sensors detection disease onset Disease progression donors elevated evaluated expression Genes H3N2 immune response in vitro in vitro transcribed RNAs influenza A influenza A virus inhibit interferon-stimulated gene interferons ISGs MDA5 Mild-to-moderate mRNA expression mRNA level multiple mechanism multiplex not differ observation onset of symptoms pathogenesis of SARS-CoV-2 patients with influenza post infection qPCR qPCR assay qPCR. remained response RNA RNAs SARS-CoV-2 SARS-CoV-2 patient Signaling Simultaneous SOCS-1 the disease transcribed transfected with type I virus White blood cell White blood cells worsening [DOI] 10.3390/v14102090 PMC 바로가기
Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidityArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome addition Analysis association B cell cancer patient Cancer patients cancer treatment Case report co-morbidity Colorectal cancer Comorbidity coronavirus correlation COVID-19 demonstrated Effect evaluated Evidence Ex vivo examined exclusion experiment HCC Hepatocellular carcinoma heterogeneity highest Immune checkpoint blockade immune dysfunction immune response immune responses Immunity immunohistochemistry immunological effect Immunological memory Immunotherapy Inflammation intra-tumor heterogeneity long-term immune memory lymphocyte Macrophage infiltration memory B cell modulate multiplex nasopharyngeal swab test Patient persistence Population positive predicted profile Reinfection response SARS-CoV-2 significantly Single-cell RNA sequencing spatial localization spatial transcriptomics Support T cell T cell dysfunction tissue tissue-localized immunity. tissues transcriptomic transcriptomic analysis Tumor tumor microenvironment understanding virus while with COVID-19 [DOI] 10.3389/fimmu.2022.978760 PMC 바로가기