A systematic review and meta-analysis of immune response against first and second doses of SARS-CoV-2 vaccines in adult patients with hematological malignancies혈액암이 있는 성인 환자의 SARS-CoV-2 백신 1차 및 2차 접종에 대한 면역 반응의 체계적인 검토 및 메타 분석Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval 95%CI affected affecting anti-CD20 therapy antibody Antibody detection Antibody Response article booster dose booster doses calculated Cancer patients chronic lymphocytic leukemia CLL Complete conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines develop Diagnosis disease doses evaluate first dose Google Google Scholar healthy subject healthy subjects Hematological malignancies Hematological malignancy higher risk highlight highlighting immune response Immunity immunization Immunocompromised immunogenicity immunosuppressive IMPROVE kinase inhibitors less leukemia lowest Lymphocytic leukemia lymphoma malignancy measure Meta-analysis mRNA mRNA-1273 Myeloma Patient Primary outcome response rate SARS-CoV-2 SARS-CoV-2 vaccine second dose secondary outcome Secondary outcomes seropositive Seropositivity severe coronavirus disease solid tumor solid tumors status subgroup subtype systematic review the disease the vaccine tumors tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors Vaccine vaccine dose vaccine's immunogenicity Web of Science [DOI] 10.1016/j.intimp.2022.109046 PMC 바로가기 [Article Type] Review
COVID-19 mRNA Vaccine in Patients With Lymphoid Malignancy or Anti-CD20 Antibody Therapy: A Systematic Review and Meta-Analysis림프성 악성종양 환자 또는 항-CD20 항체 치료 환자의 코로나19 mRNA 백신: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-08-012022-09-11 Journal: Clinical lymphoma, myeloma & leukemia [Category] 치료제, [키워드] anti-CD20 antibody articles attenuate B-cell B-cell target therapy cellular response Cellular responses chronic lymphocytic leukemia CLL COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines Effectiveness exhibited humoral Humoral and cellular responses Humoral response independent independent of individual leukemia Long-term follow-up Lymphocytic leukemia lymphoid lymphoma malignancies malignancy material Meta-analysis mRNA mRNA vaccine mRNA vaccines Myeloma Patient PROTECT registration number response to vaccination retrieved review risk risk ratio Seropositivity significantly subtype systematic review T cell T cell responses therapy These data vaccination Vaccine were used within 6 months [DOI] 10.1016/j.clml.2022.03.012 PMC 바로가기 [Article Type] Meta-Analysis
Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies항암치료를 받는 환자의 코로나19 백신접종에 대한 항체 및 T세포 반응Article Published on 2022-06-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료제, [키워드] active treatment adrenal crisis Adrenal insufficiency Affect Anti-CD20 antibodies Anti-CD20 antibody Anti-viral antibodies antibody antibody formation Antibody titer Antibody titers Anticancer therapy B cells B-cell B.1.617.2 blockade Cancer CD4 CD8 Cell cellular Chemoimmunotherapy Chemotherapy Corticosteroids COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccine trials cross-reactive cytokine detectable develop dose doses effector cells Endocrine expressed follicular generate healthy donor healthy donors helper cells Humoral response hypoadrenalism Hypothesis IgG antibody titer immune Immunocompromised immunogenic immunogenicity immunogenicity, vaccine Immunotherapy intracellular cytokine staining Lymphocytes mRNA vaccine Multiple myeloma Myeloma n=36 no differences oncology patients Participants Patient Patients with cancer PD-1 peptide peptides Phase 3 profile Prophylactic RBD reactivity receiving Receptor binding domain Safe seronegative seronegative patient Side effect solid tumors spike Spike protein steroid Steroids Stress symptomatic T cell T cell response T cell responses T cells T follicular helper cells T-lymphocytes targeted therapy the SARS-CoV-2 therapy Treatment treatment groups tumors Two patient two patients vaccination Vaccinations Vaccine variant spike was measured were assessed were excluded wild-type WT spike [DOI] 10.1136/jitc-2022-004766 PMC 바로가기 [Article Type] Article
Risk of SARS-CoV-2 Breakthrough Infection in Vaccinated Cancer Patients: A Retrospective Cohort Study예방 접종을 받은 암 환자의 SARS-CoV-2 돌발 감염 위험: 후향적 코호트 연구Article Published on 2022-05-212022-09-11 Journal: Journal of Hematology & Oncology [Category] COVID19(2023년), SARS, 변종, [키워드] Breakthrough infection cancer patient Cancer patients COVID curated database death rate death rates determine dose Effectiveness Efficacy General population Height hematologic Hematologic malignancy higher risk Hospitalization malignancies malignancy Messenger RNA mRNA mRNA vaccine Multiple myeloma Myeloma oncology outcome Patient patient data remained Research risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection severe SARS Therapies therapy university vaccination Vaccine variant [DOI] 10.1186/s13045-022-01290-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2-mRNA Booster Vaccination Reverses Non-Responsiveness and Early Antibody Waning in Immunocompromised Patients – A Phase Four Study Comparing Immune Responses in Patients With Solid Cancers, Multiple Myeloma and Inflammatory Bowel DiseaseSARS-CoV-2-mRNA 부스터 백신 접종은 면역 저하 환자의 무반응 및 조기 항체 약화를 역전시킵니다 - 고형암, 다발성 골수종 및 염증성 장 질환 환자의 면역 반응을 비교하는 4상 연구Clinical Trial Published on 2022-05-122022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] analyzed anamnestic response anamnestic vaccine-specific response antibody Antibody testing Autoimmune disease B-cell BNT162b2 booster booster vaccination Cancer patients CD19 cellular cellular response Control control group controls correlated COVID-19 cytokine response declined Effectiveness EudraCT group help highest humoral humoral and cellular vaccine-specific responses IBD identify IFN-γ response IgG IgG level IL-2 immune responses immunodeficiency IMPROVE individual Inflammatory bowel disease inhibitor inhibitors intervals knowledge mRNA mRNA vaccination mRNA-1273 Multiple Multiple myeloma Myeloma neutralizing antibody non-infected Open-label Patient patients patients treated patients under immunosuppression/immunomodulation Patients with cancer persistence phase response SARS-CoV-2 SARS-CoV-2 mRNA vaccination SARS-CoV-2 vaccination second dose Solid solid tumor SOT TNF-α Trial undetectable vaccination Vaccine waning of immune responses. [DOI] 10.3389/fimmu.2022.889138 PMC 바로가기 [Article Type] Clinical Trial
Immune response to COVID-19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T-cell responseCOVID-19 백신 접종에 대한 면역 반응은 백신 주도의 발산 T 세포 반응을 통한 질병 통제 및 항골수종 요법에 의해 약화됩니다.Article Published on 2022-05-012022-09-11 Journal: British Journal of Haematology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] administration anti-CD38 Anti-spike anti-spike antibody antibody Antibody Response Antigen B-cell Bacterial blood sample Blood samples Cellular immune response cellular response Clinical significance COVID-19 vaccination COVID-19 vaccine disease disease severity Gender humoral humoral immune response immune responses interferon gamma male maturation Myeloma Patient patients Pfizer-BioNTech positive positive result predicted produced Prospective Study Protein provided reported required respond poorly response serology study cohort T-cell Response therapy vaccination Vaccine vaccine dose Viral [DOI] 10.1111/bjh.18066 PMC 바로가기 [Article Type] Article
Comorbidities and mortality rate in COVID-19 patients with hematological malignancies: A systematic review and meta-analysisReview Published on 2022-05-012023-07-08 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), [키워드] COVID-19 leukemia lymphoma Myeloma review [DOI] 10.1002/jcla.24387 PMC 바로가기 [Article Type] Review
Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative백신 접종을 받은 암 환자의 획기적인 COVID-19 감염의 위험과 결과: 국가 COVID 코호트 협력의 실제 증거Article Published on 2022-05-012022-09-11 Journal: Journal of clinical oncology : official journal of [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI adjusted age analyzed BNT162b2 BNT162b2 vaccine Bone marrow Bone marrow transplantation booster Breakthrough infection breakthrough infections Cancer cancers Cohort controls COVID COVID-19 COVID-19 case COVID-19 cases COVID-19 infection COVID-19 infections Evidence hematologic Hematologic malignancy higher risk identify immunosuppressive effect increased risk leukemia Logistic regression lymphoid lymphoma malignancies medications Moderna mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA-1273 Multiple myeloma Myeloma National new SARS-CoV-2 Odds ratios outcome outcomes Patient patients Patients with cancer Pfizer ranged risk SARS-COV-2 infection SARS-CoV-2 variants Sex significantly higher smoking smoking status Solid solid tumors Tumor tumors vaccination Vaccine vaccine dose variants was reduced [DOI] 10.1200/JCO.21.02419 PMC 바로가기 [Article Type] Article
Adaptation of the PERCEPT myeloma prehabilitation trial to virtual delivery: changes in response to the COVID-19 pandemic가상 분만에 대한 PERCEPT 골수종 사전 재활 시험의 적응: COVID-19 전염병에 대한 대응의 변화Review Published on 2022-04-082022-09-11 Journal: BMJ Open [Category] 임상, [키워드] adaptation addition autologous benefit bone Bone marrow Bone marrow transplantation change changes in clinical pathway COVID-19 COVID-19 pandemic development effective enrolled Exercise intervention feasibility highlight impacted Intervention Myeloma pandemic participant Participants pathway patients physical activity provided Randomised trial recipients recruit recruitment registration number rehabilitation rehabilitation medicine required Research Ethics Research Ethics Committee stem cell Stem cell transplantation Study protocol Trial trial protocol [DOI] 10.1136/bmjopen-2021-059516 PMC 바로가기 [Article Type] Review
Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patientsReview Article Published on 2022-02-022024-09-04 Journal: Leukemia [Category] 대상포진, [키워드] Adaptive immunity Innate immunity Myeloma Preventive medicine [DOI] 10.1038/s41375-021-01506-9 PMC 바로가기 [Article Type] Review Article