neuronal – Page 2 – Communicable Diseases Research

Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala

Research

Published on 2022-07-152022-10-05
Journal: Molecular Psychiatry [Category] 유전자 메커니즘,

Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis

소아 및 장기 코로나의 다기관 염증 증후군: SARS-CoV-2 바이러스 초항원 가설

Article

Published on 2022-07-072022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] addition Alter attribute autoantibodies autoantibody autoimmune responses Autoimmunity Bacterial binding Cell change children children with MIS-C circulating computational studies conjunctivitis conserved contribute COVID COVID-19 develop elevated exposure to feature febrile Fever Gastrointestinal glycoprotein Gut high affinity hyperinflammation immune response Immunosequencing Inflammatory inflammatory disease initial Kawasaki disease Long Long COVID MHC class II MHC Class II proteins MIS-C MIS-C multisystem inflammatory syndrome in children motif Multiorgan Neurological complication Neurological complications Neurological symptom Neurological symptoms neuronal neurotoxin neurotoxin-like segment oral mucosa PASC Patient patients pediatric Peripheral blood peripheral blood samples persistence persistent fever Post-acute sequelae of COVID-19 (PASC) prolonged exposure promote Proteins rashes resulting SAgs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 virus SEB Sequence analysis serum cytokine levels severity Shock similarity staphylococcal enterotoxin staphylococcal enterotoxin B strawberry strawberry tongue Structure superantigen superantigen-like motif. syndrome systemic hyperinflammation T-cell receptor TCR TCRs the SARS-CoV-2 the SARS-CoV-2 virus Toxic shock Toxic shock syndrome TRBV11-2 triggered TSS unique β variable
[DOI] 10.3389/fimmu.2022.941009 PMC 바로가기 [Article Type] Article

The Karolinska NeuroCOVID study protocol: Neurocognitive impairment, biomarkers and advanced imaging in critical care survivors

Karolinska NeuroCOVID 연구 프로토콜: 중환자 생존자의 신경인지 장애, 바이오마커 및 고급 영상

Article

Published on 2022-07-012022-09-11
Journal: Acta Anaesthesiologica Scandinavica [Category] MERS, 바이오마커, 진단,

[키워드] Activation assessment Biomarker Biomarkers Brain brain injury brain MRI Care cause causes cellular cerebrospinal cerebrospinal fluid change Coagulopathy cognitive consequence COVID-19 COVID-19 pandemic Critical Critical care degeneration discharge disease exhibiting expressed fatigue finding Follow-up functional Health health-care system ICU identify immune impairment individual Inflammation Intervention magnetic resonance imaging marker Mental molecular MRI myriad neurocognitive neurocognitive disorders neurodegenerative neurological Neurological deficit neurological deficits neuronal outcome pathological mechanism Patient patient outcome assessment. patients treated performed plan plasma rehabilitation serum severe COVID-19 survivor Survivors Symptom target targets two patients
[DOI] 10.1111/aas.14062 PMC 바로가기 [Article Type] Article

Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice

hACE2 형질전환 마우스에서 SARS-CoV-2 감염 후 시간적 뇌 병변

Article

Published on 2022-07-012022-09-11
Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis animal model astrogliosis Beta Brain cause Central nervous system Cerebellum characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop different time points distribution Encephalitis hACE2 hACE2-transgenic mice histopathological immunohistochemistry immunolabeling inoculation lesion meningoencephalitis mice mucosa necropsies necropsy Neuroinflammation Neurological disease neuronal neurons Neuropathology nonsuppurative olfactory other organ other organs panel of antibodies panel of antibody performed post inoculation processed question reached Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spongiosis Spread susceptible thrombosis transgenic mice vacuolar vacuolar degeneration variants Vasculitis virological assay virological assays virus
[DOI] 10.1177/03009858211066841 PMC 바로가기 [Article Type] Article

Safety profile of SARS-CoV-2 vaccination in patients with antibody-mediated CNS disorders

항체 매개 CNS 장애 환자에서 SARS-CoV-2 백신 접종의 안전성 프로파일

Multicenter Study

Published on 2022-07-012022-09-12
Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), MERS, SARS, 진단,

Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing

Research

Published on 2022-06-302022-10-05
Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘,

[키워드] abrupt onset Anxiety biological pathways CACNA1B candidate candidate gene categories category children Cohort conducted de novo Deleterious described disorder disrupting etiology European Evidence Exome expressed functional GABRG2 Genes Genetic variant Genetic variation GRIN2A heterogeneous identification immune functions Infection infections irritability microglia Mutation nervous system neuronal Neuropsychiatric NLRC4 pathological mechanism pediatric peripheral immune response PLCG2 PPM1D RAG1 regulate selected Sequencing SGCE SHANK3 Stressor subject swings Symptom syndrome SYNGAP1 union variant WES WGS whole genome
[DOI] 10.1038/s41598-022-15279-3 [Article Type] Research

K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research

K18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점

Review

Published on 2022-06-282022-09-11
Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development
[DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review

Serum glial fibrillary acidic protein is a body fluid biomarker: A valuable prognostic for neurological disease – A systematic review

Review article

Published on 2022-06-012022-10-05
Journal: International immunopharmacology [Category] 바이오마커,

[키워드] Acidic Alzheimer’s disease applied articles association Asthma Astrocyte Ataxia Autism spectrum disorders Biomarker Biomarkers Blood bloodstream Cell Central nervous system COVID-19 database depressive described detect Diabetic diagnostic disintegration disorder early diagnosis elevated exclusion criteria facilitate GFAp Glioblastoma initial search Intermediate filament lobar multiple sclerosis neurodegeneration neurodegenerative disorders Neurological disease Neurological diseases Neurological disorder Neurological disorders neuronal Parkinson disease prognostic Protein Regulation reported Schizophrenia Seizures Serum level Spinal cord injury stroke systematic review the disease tissue Web of Science Wilson
[DOI] 10.1016/j.intimp.2022.108624 [Article Type] Review article

Allergic shiners in a patient with cough-variant asthma: a case report

기침-변형 천식 환자의 알레르기 샤이너: 증례 보고

Case Reports

Published on 2022-05-282022-09-11
Journal: Journal of Medical Case Reports [Category] 변종,

[키워드] Adults Affect allergic Allergic shiners Asthma baseline Case report cause Challenge test characterized Chest chest X-ray chronic Chronic cough classic Computed tomography coronavirus disease Coronavirus disease 2019 cough Cough-variant asthma. coughing Diagnosis disappearance example excessive use extreme eyelid General population hacking cough heliotrope rash High-resolution Hyperinflation initiated Laboratory test limits Methacholine mimicking neuronal pandemic parameters pathway Patient phenotype Physical examination positive presenting Pulmonary function test Rash resulting Reversibility sensitivity severity Symptom Treatment tree urge
[DOI] 10.1186/s13256-022-03423-6 PMC 바로가기 [Article Type] Case Reports

Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms

감염 또는 신경학적 증상이 없는 대조군과 비교하여 COVID-19 감염 및 신경학적 증상이 있는 환자의 뇌척수액에서 바이러스 항원 및 염증성 바이오마커

Article

Published on 2022-05-022022-09-11
Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법,

[키워드] 95% CI age Antigen Biomarker capture Central nervous system cerebrospinal fluid clinical CNS component Concentration contribute Control control group controls correlated COVID COVID-19 COVID-19 infection COVID-19 severity cross-sectional cross-sectional study CSF Cytokines detectable disease severity Encephalopathy Evidence evidence of Gothenburg Health Organization healthy control highlight IL-10 IL-6 immune activation immune response immune responses immunoassay Infection Inflammatory Inflammatory biomarker inflammatory biomarkers Injury interferon interferon γ interleukin IQR male median microglobulin moderate Moderate COVID-19 Necrosis neurologic neuronal no differences nucleocapsid antigen Older outcome participant Participants Pathogenesis Patient patient groups platform Principal component principal component analysis Protein Sahlgrenska University Hospital SARS-COV-2 infection SARS-CoV-2 nucleocapsid scale severe COVID-19 severe disease significantly significantly higher Study protocol Swedish Symptom Symptoms test results Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α Viral Viral antigen viral invasion Viral RNA was performed with COVID-19 World Health Organization β2-microglobulin
[DOI] 10.1001/jamanetworkopen.2022.13253 PMC 바로가기 [Article Type] Article