Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma미세 유체 특성 분석은 인간 혈장에서 광범위한 SARS-CoV-2 항체 친화성을 보여줍니다Research Article Published on 2021-11-302022-09-12 Journal: Life Science Alliance [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] affinity aggregate antibody antibody affinity Antibody Response antiviral antibodies antiviral antibody Asymptomatic cellular characterisation Clinical outcome complementary Complexes Concentration COVID-19 infection Critically ill cytopathic determine dissociation domain effective healthy donors Human plasma indicate individual lethal magnitude mild symptoms neutralisation neutralisation assays neutralise plasma plasma sample plasma samples polyclonal polyclonal antibody predict receptor reveal SARS-CoV-2 antibody SARS-CoV-2 infections sera seropositive individual seropositive individuals significantly targets the antibody therapeutic Vaccinations virus [DOI] 10.26508/lsa.202101270 PMC 바로가기 [Article Type] Research Article
Neutralisation of SARS‐CoV‐2 by anatomical embalming solutions해부학적 방부제 솔루션을 통한 SARS-CoV-2 중화Brief Communication Published on 2021-10-112022-09-12 Journal: Journal of Anatomy [Category] MERS, SARS, 진단, [키워드] absence anatomical Anatomy body donation cadaver Cadaveric COVID‐19 cytotoxicity dilutions Donor effective fixation foundation gross anatomy Ireland majority neutralise pandemic preservation Safe SARS‐CoV‐2 SARS‐CoV‐2 virus specimen Suspension Teaching tested Transmissibility United Kingdom virus [DOI] 10.1111/joa.13549 PMC 바로가기 [Article Type] Brief Communication
Continued influence of misinformation in times of COVID ‐19Regular Empirical Article Published on 2021-08-262022-10-29 Journal: International journal of psychology : Journal inte [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] Affect Attitude consequence Continued influence effect COVID COVID‐19 COVID‐19 misinformation decrease Effect Effects expected Fact‐checking Health hospital information investigated Negativity bias neutralise participant Persuasive impact positive public health recipient reduced remained Result reversed were measured [DOI] 10.1002/ijop.12805 PMC 바로가기 [Article Type] Regular Empirical Article
Validation of a commercially available indirect assay for SARS-CoV-2 neutralising antibodies using a pseudotyped virus assay유사형 바이러스 분석을 사용한 SARS-CoV-2 중화 항체에 대한 상업적으로 이용 가능한 간접 분석의 검증Article Published on 2021-05-012022-09-10 Journal: The Journal of Infection [Category] Fulltext, SARS, 진단, 치료기술, 치료제, [키워드] anti-RBD assays cell lines demonstrated ELISA functional immune response Highlights human sera immune responses immunologically Linear regression measure neutralisation neutralisation assay neutralise neutralising neutralising antibody objective Patient positive correlation provide Pseudotyped virus RBD binding antibodies response responses responses against Result S protein SARS-CoV-2 SARS-CoV-2 neutralising antibody SARS-CoV-2 S serum sample serum samples spike target cell tested the RBD validation Viral viral infection was measured [DOI] 10.1016/j.jinf.2021.03.010 PMC 바로가기 [Article Type] Article
Canakinumab as treatment for COVID-19-related pneumonia: A prospective case-control studyCOVID-19 관련 폐렴 치료제로서의 카나키누맙: 전향적 사례 대조 연구Observational Study Published on 2021-03-012022-09-12 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 임상, 진단, 치료법, [키워드] 95% CI administration antibody asked canakinumab Case-control case-control study Clinical improvement COVID-19 discharge duration of hospitalisation Efficacy and safety evaluate examined hospital discharge IL-1β Invasive mechanical ventilation lung damage marker median Mild neutralise oxygen status PaO Patient patients treated patients with moderate Pneumonia Prognosis receive reduction in restored SARS-CoV-2 SARS-CoV-2. Side-effect significant decrease significant increase Standard of care survival treated Treatment Ventilation [DOI] 10.1016/j.ijid.2020.12.073 PMC 바로가기 [Article Type] Observational Study
Breadth and function of antibody response to acute SARS-CoV-2 infection in humans인간의 급성 SARS-CoV-2 감염에 대한 항체 반응의 범위와 기능Research Article Published on 2021-02-262022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, 진단, 치료법, [키워드] ACE2 ACE2-blocking response acute SARS-CoV-2 infection acute viral infection analysed anti-non-RBD S1 Anti-RBD antibodies Anti-RBD antibody Anti-RBD MAb Anti-RBD MAbs anti-receptor-binding domain anti-S2 Anti-spike anti-spike MAbs antibody Antibody Response Antibody responses Antibody-mediated immunity average betacoronavirus binding blockade blocked clone Clusters combinations Complete COVID-19 outbreak COVID-19 patient cross-react elicited epitope Epitopes expansion Fever FIVE glycoprotein Health Human Human coronavirus human coronavirus OC43 humans Humoral response IgG Immunity independent assays mAbs memory B cell memory B cells monoclonal antibody neutralise neutralising Neutralising activity Neutralising Antibodies neutralising antibody neutralising antibody response non-overlapping epitope non-overlapping epitopes non-RBD S1 nucleocapsid offer outbreak Patient peripheral plasmablast response plasmablast plasmablast response plasmablast responses potent Prolonged fever Prophylactic RBD reactive Receptor-binding domain recovered patient Region responses SARS-CoV-2 SARS-COV-2 infection separate cluster sera serological Serological and plasmablast responses serology somatic mutations spike glycoprotein subset tested the RBD the receptor-binding domain therapeutic agent therapeutic agents titre Viral viral infection Virus spike wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1009352 PMC 바로가기 [Article Type] Research Article
Case Report: Adequate T and B Cell Responses in a SARS-CoV-2 Infected Patient After Immune Checkpoint Inhibition사례 보고: 면역 체크포인트 억제 후 SARS-CoV-2 감염 환자의 적절한 T 및 B 세포 반응Case Reports Published on 2021-02-042022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] Adaptive immune response Adaptive immunity addition Adequate Affect analyzed antibody B-cell response baseline Cancer Cell cellular chemotaxis clinician COVID-19 outbreak COVID-19 pandemic evaluate expression humoral humoral immune response IgM and IgG Immune checkpoint inhibitor Immune checkpoint inhibitors immune response immune system Immunotherapy Infection inhibition kidney neoplasms marker maturation neutralise oncology patient pandemic Patient plasma sample renal response risk factor SARS-CoV-2 subset T cell the SARS-CoV-2 therapy treated Treatment were measured [DOI] 10.3389/fimmu.2021.627186 PMC 바로가기 [Article Type] Case Reports