A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike aloneArticle Published on 2020-10-232022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] added alleviate Antigen antigenicity Cryoelectron microscopy described elicit expressed expression ferritin fused glycoprotein Helicobacter pylori immunogen increasingly mammalian murine neutralizing response neutralizing responses parainfluenza platform prefusion prefusion conformation respiratory syncytial virus reveal SARS-CoV-2 stimulate strong immune response trimer trimeric vaccination Vaccines viral antigens viral infection [DOI] 10.1038/s41598-020-74949-2 PMC 바로가기 [Article Type] Article
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 Research Published on 2020-07-132022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, 치료기술, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 B cell Biomarker cellular receptor characterized circulating coronavirus coronavirus disease COVID-19 effective elicited Eliciting follicular Frequency glycoprotein hallmark helper T cell Human humoral Humoral immunity immune Immunity immunogenic membrane memory B cell Neutralizing activity neutralizing antibody neutralizing epitopes neutralizing responses pandemic Patient phenotype plasma Prevent Receptor binding domain recovered patient resolved response robust S-based vaccine S-specific antibodies SARS-CoV-2 SARS-COV-2 infection subject Vaccine Vaccine development virion with COVID-19 [DOI] 10.1038/s41591-020-0995-0 [Article Type] Research