Humoral immune response of BBIBP COVID-19 vaccination before and after the booster immunization추가 접종 전후 BBIBP COVID-19 백신의 체액성 면역 반응Multicenter Study Published on 2022-08-012022-09-12 Journal: Allergy [Category] MERS, SARS, 진단, [키워드] Administered antibody antibody persistence Antibody Response Antibody titer booster booster dose Coronavirus disease 2019 COVAX COVID-19 COVID-19 vaccination COVID-19 vaccine cVNT declined decrease disease dose elevated elicited healthy highlight IgA IgG immune response Immunity immunization inactivated Inactivated vaccine injection levels of antibody Month multicenter neutralization Neutralizing Neutralizing antibodies Neutralizing titer notable Participants peaked postvaccination pseudovirus recruited SARS-CoV-2 serum antibody shown Standard dose sVNT Vaccine vaccine. virus neutralization test [DOI] 10.1111/all.15271 PMC 바로가기 [Article Type] Multicenter Study
Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum폴리(I:C) 플러스 명반과 관련된 SARS-CoV-2 삼량체 스파이크 단백질의 면역원성Article Published on 2022-06-302022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition adjuvant adjuvants alum antibody B cell BALF Bronchoalveolar lavage fluid CD4 CD8 Cellular immune response Combination domain ELISA enzyme evaluated expected germinal centers IgA IgG IgG anti-spike antibody IgG1 IgG2a immunization immunogenicity immunosorbent in vitro inactivated induce intradermal route lung Lung inflammation mice Neutralization assay Neutralizing titer neutralizing titers neutrophil recruitment New Poly (I:C) poly(I:C positive prefusion produced producing Protein RBD reduced reduction in required SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 virus serum spike Spike protein Subtypes supported T cell Th1 Th1 phenotype the SARS-CoV-2 trimeric vaccination Vaccination strategy Vaccine vaccine. [DOI] 10.3389/fimmu.2022.884760 PMC 바로가기 [Article Type] Article
Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization인간 또는 동물 ACE2 매개 바이러스 진입 및 중화에 대한 우려의 SARS-CoV-2 변이체에서 스파이크 돌연변이의 영향Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal animals antibodies antibody Antibody neutralization antibody neutralization activity Beta caused cell entry cell line cell lines circulating common strain comparable concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Delta determine Effect Effectiveness Efficiency Express expressing global health Health host range Human human ACE2 Impact infect infecting information mink MOST Mutation neutralization neutralizing antibody Neutralizing titer neutralizing titers nine omicron Omicron variant over pandemic parental Protein pseudovirus pseudoviruses public policy reduced respiratory reveal S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly socioeconomics spike spike mutations Spread Substitution substitutions Support susceptible tested the S protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic therapeutic antibodies Transmissibility Transmission Vaccine variant variants variants of concern variety Viral viral cell viral entry viral neutralization virulence virus virus entry virus replication Virus replication. VoC VOCs zoonotic [DOI] 10.1128/spectrum.01789-21 PMC 바로가기 [Article Type] Article
Resistance of SARS-CoV-2 Omicron BA.1 and BA.2 Variants to Vaccine-Elicited Sera and Therapeutic Monoclonal AntibodiesSARS-CoV-2 Omicron BA.1 및 BA.2 변이체의 백신 유도 혈청 및 치료용 단일클론 항체에 대한 내성Article Published on 2022-06-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] AstraZeneca BNT162b2 BNT162b2 vaccine COVID-19 D614G Effectiveness Emergency use fold immunization individual Lilly LY-CoV555 mixture monoclonal monoclonal antibodies monoclonal antibody monoclonal antibody therapy mutated neutralized Neutralizing titer omicron Omicron BA.2 Omicron variants parental Regeneron REGN10933 REGN10987 remained resistance SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe COVID-19 significantly Spike protein spike protein. Spike proteins therapeutic therapy titer titers Vaccine variant variants virus [DOI] 10.3390/v14061334 PMC 바로가기 [Article Type] Article
Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변종에 대한 CpG-보강 S-2P 소단위 백신의 중화 능력 평가Article Published on 2022-06-102022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha Alpha variant aluminum aluminum hydroxide antibody Antigen Beta Beta variant beta variants breath clinical trial coated with concern coronavirus coronavirus 2 COVID-19 CpG D614G demonstrated dose effective Effectiveness elicit elicited Evaluating High dose Human humans hydroxide immune response immunization immunized immunogenicity medium neutralization neutralization ability neutralization activity Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers Phase 1 prefusion pseudovirus pseudoviruses RAT RATs reduced reduction reduction in respiratory retained S-2P SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants serum antibodies serum antibody serum sample serum samples severe acute respiratory syndrome Coronavirus significantly Spike protein subject subunit subunit SARS-CoV-2 vaccine the SARS-CoV-2 Vaccine Vaccines variant Variant of concern. variants VOCs wild-type [DOI] 10.1093/cid/ciab711 PMC 바로가기 [Article Type] Article
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2오미크론 특이적 mRNA 백신 단독 및 SARS-CoV-2에 대한 이종 부스터Article Published on 2022-06-062022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] animals Antibody Response assessment background level Beta binding antibody boost booster comparable delta variant elicit generate globe Heterologous homologous immune evasion in vivo increase injection LNP mice mRNA vaccination mRNA vaccine neutralization potency Neutralizing titer neutralizing titers omicron Omicron variant reduce reduction in responses against SARS-CoV SARS-CoV-2 These data titers vaccination Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41467-022-30878-4 PMC 바로가기 [Article Type] Article
A Single-Round Infection Fluorescent SARS-CoV-2 Neutralization Test for COVID-19 Serological Testing at a Biosafety Level-2 LaboratoryBiosafety Level-2 실험실에서 COVID-19 혈청학적 테스트를 위한 단일 라운드 감염 형광 SARS-CoV-2 중화 테스트Article Published on 2022-06-022022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accuracy Antibody Response Antiviral biosafety BSL-2 BSL-2 laboratory BSL-3 facilities correlated COVID-19 COVID-19 patient evaluated fluorescent gold standard Infection lab Laboratory Large-scale testing linearity live viruses natural infection neutralization Neutralization assay neutralizing antibody Neutralizing titer plaque reduction neutralization plasma PRNT R 2 reproducibility robust SARS-CoV-2 SARS-CoV-2 virus sensitivity Sensitivity and specificity serological test serum single-round infection fluorescent SARS-CoV-2 virus specificity specificity. specimens Test Testing vaccination [DOI] 10.3390/v14061211 PMC 바로가기 [Article Type] Article
A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants멀티토프 SARS-CoV-2 백신은 Delta 및 Omicron 변이체에 대해 오래 지속되는 B 세포 및 T 세포 면역을 제공합니다Clinical Trial Published on 2022-05-162022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] adverse event Antibody titers Asia B cell booster Breakthrough infection breakthrough infections center conducted conserved Control COVID-19 cross-reactive cytotoxic T lymphocyte Delta disease control dose elicited epitope Epitopes evaluated fatigue healthy helper T cell Heterologous human convalescent sera Immunity immunization immunogenicity Inc. injection site pain long-lasting lymphocyte membrane memory immunity Mild Ministry of Health Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer nucleocapsid omicron Omicron variants peptide peptides Peptides. Phase I placebo-controlled Protein provide Randomized representing responsible safety profile sarbecovirus SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Serious Adverse Event Serious Adverse Events subunit Subunit vaccine T cell Taiwan Trial trials Vaccine variant variants of SARS-CoV-2 virus-neutralizing antibody VOCs waning immunity Welfare were recorded [DOI] 10.1172/JCI157707 PMC 바로가기 [Article Type] Clinical Trial
Fitness of B-Cell Responses to SARS-CoV-2 WT and Variants Up to One Year After Mild COVID-19 – A Comprehensive Analysis경증 COVID-19 이후 최대 1년까지 SARS-CoV-2 WT 및 변이체에 대한 B 세포 반응의 적합성 - 종합 분석Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Affinity maturation All participants Alpha Anti-RBD antibodies antibodies antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen antigen-specific memory B cells assays avidity B-cell binding binding antibodies binding antibody Comprehensive correlated COVID-19 declined Delta delta variant domain ELISA ELISPOT evaluate fitness Gamma IgA IgG memory B memory B cell memory B cells memory B-cell Mild N protein neutralization Neutralizing Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer neutralizing titers nucleocapsid participant plasmablast plasmablast responses plasmablasts plasmablasts. post infection predicted Protein remained response SARS-CoV-2 SARS-CoV-2 specific memory B cells SARS-CoV-2 WT significantly increased symptomatic thiocyanate titers variant variants variants of concern waned were assessed were measured wild-type Year [DOI] 10.3389/fimmu.2022.841009 PMC 바로가기 [Article Type] Article
Humoral Response to BNT162b2 Vaccine Against SARS-CoV-2 Variants Decays After Six MonthsSARS-CoV-2 변이체에 대한 BNT162b2 백신에 대한 체액 반응은 6개월 후 쇠퇴합니다.Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Against age age and gender Alpha Alter analyzed B.1 BNT162b2 BNT162b2 vaccine carried changes in Complete D614G decay decrease Delta determine Effectiveness evade evaluated Evidence FIVE Follow-up Gamma GraphPad humoral immune response immune escape mutation immune escape mutations immune response Immunity immunization immunogenicity individual men Month Neutralization assay Neutralizing Neutralizing activity Neutralizing antibodies neutralizing capacity Neutralizing titer Older participant plaque reduction neutralization Prospective Study protocols raised reduction response SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants serum serum sample serum samples severity shown Support titer titers Transmissibility vaccination Vaccine variant Variant. variants Viral viral variant Viral variants was measured [DOI] 10.3389/fimmu.2022.879036 PMC 바로가기 [Article Type] Article