Inhibition of hepatic NLRP3 inflammasome ameliorates non-alcoholic steatohepatitis/hepatitis B – induced hepatic injuryArticle Published on 2023-01-012023-06-13 Journal: Clinics and research in hepatology and gastroenter [Category] B형 간염, [키워드] HBV MCC950 NLRP3 steatosis [DOI] 10.1016/j.clinre.2022.102056
Contribution of prgH gene for Salmonella Pullorum to virulence and the expression of NLRP3, Caspase-1 and IL-1β in chickensarticle Published on 2022-10-312024-09-01 Journal: Microbial Pathogenesis [Category] 살모넬라증, [키워드] caspase-1 IL-1β NLRP3 prgH Sallmonella pullorum virulence [Article Type] article
Innate Immune Response and Inflammasome Activation During SARS-CoV-2 InfectionArticle Published on 2022-10-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Activation Antiviral characterized Clinical outcome COVID-19 COVID-19 outbreak Defense develop drug Effect evade flexibility Genome human pathogen IL-18 IL-1β IL-6 immune immune response immunopathology implicated IMPROVE Infection infective Inflammasome inflammasome pathway inflammatory disease inhibiting Innate innate immune response innate immune system interferon Intervention mutant strain NLRP3 novel coronavirus SARS-CoV-2 pandemic pathology Predictive preventive measure pro-inflammatory cytokine promote protective role public health receptor Replication response responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown the interferon treating COVID-19 Trigger urgent investigation Vaccine vaccine candidate vaccine candidates vaccine for COVID-19 viral disease viral evolution virus viruses [DOI] 10.1007/s10753-022-01651-y PMC 바로가기
Disengaging the COVID-19 Clutch as a Discerning Eye Over the Inflammatory Circuit During SARS-CoV-2 InfectionReview Published on 2022-10-012023-07-09 Journal: Inflammation [Category] COVID19(2023년), [키워드] COVID-19 IL Mitochondria NLRP3 NOx ROS SARS-CoV-2 TLR. [DOI] 10.1007/s10753-022-01674-5 PMC 바로가기 [Article Type] Review
Adding colchicine to tocilizumab in hospitalized patients with severe COVID-19 pneumonia: An open-label randomized controlled trialArticle Published on 2022-09-302022-11-15 Journal: Medicine [Category] SARS, 진단, [키워드] 1:1 added Adding Analysis antagonists Anti-inflammatory anti-inflammatory agent approved cascade center Colchicine Corporation cytokine Cytokine storm Efficacy and safety Ethics evaluate hospitalized patient IL-6 IL-6 blockade include Inflammasome inhibiting institutional review board Invasive mechanical ventilation Local mechanism of action Mortality NLRP3 Open-label Patient peer-reviewed Primary outcome Randomized Randomized controlled trial receptor receptor protein reduce Result risk safety profile severe COVID-19 Severe COVID-19 pneumonia Study protocol submitted Tocilizumab upstream [DOI] 10.1097/MD.0000000000030843 PMC 바로가기
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infectionArticle Published on 2022-09-162022-11-16 Journal: Science Advances [Category] SARS, 신약개발, [키워드] acute respiratory syndrome AIM2 Asymptomatic COVID-19 autophagy coronavirus COVID-19 develop disease FDA-approved drug human monocyte identification immunomodulatory drug immunomodulatory function impair implicated in vitro in vivo independent induce Inflammasome inflammasome activation inflammasomes inflammatory process information inhibit inhibited inhibitors Mild NIC NLRP3 NLRP3 inflammasome Patient patients with COVID-19 PBMC performed provide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication treat Treatment [DOI] 10.1126/sciadv.abo5400 PMC 바로가기
Development of a cell line-based in vitro assay for assessment of Diphtheria, Tetanus and acellular Pertussis (DTaP)-induced inflammasome activation디프테리아, 파상풍 및 세포외 백일해(DTaP) 유도 염증소체 활성 평가를 위한 세포주 기반 인 비트로 분석법 개발Article Published on 2022-09-092024-08-19 Journal: Vaccine [Category] 백일해, 파상풍, [키워드] adjuvant aluminium hydroxide Aluminium phosphate consistency approach Inflammasome NLRP3 [DOI] 10.1016/j.vaccine.2022.08.022
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, BrazilArticle Published on 2022-09-052022-11-16 Journal: BioMed Research International [Category] SARS, 변종, 유전자 메커니즘, [키워드] activated allele association Asymptomatic Brazil CARD8 center clinical clinical evolution Clinical management clinical manifestations contributing to COVID-19 COVID-19 severity death disease disease severity Factors Genetic Genetic variant Genotype group Haplotype Host host cells Inflammasome Inpatient investigated knowledge logistic regression models mechanism moderate NLRP3 NLRP3 inflammasome outcomes Patient performed polymorphism Polymorphisms profile protection Real-time PCR recruited Rio de Janeiro risk risk factor SARS-COV-2 infection SARS-CoV-2-infected individual scale severe symptom severity Significant single-nucleotide SNP SNPs Symptom the WHO two group two groups variants virus was determined WHO with mild disease [DOI] 10.1155/2022/9082455 PMC 바로가기
Preeclampsia and COVID-19: the Role of Inflammasome ActivationReview Published on 2022-09-012023-07-09 Journal: Current hypertension reports [Category] COVID19(2023년), [키워드] COVID-19 Inflammasome NLRP3 preeclampsia [DOI] 10.1007/s11906-022-01195-4 PMC 바로가기 [Article Type] Review
Exploring the mechanism of action of Xuanfei Baidu granule (XFBD) in the treatment of COVID-19 based on molecular docking and molecular dynamicsArticle Published on 2022-08-102022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acting Activation alleviate Analysis analyzed Anti-inflammatory effects Apoptosis Baidu binding binding energy binding free energy bioinformatics Bioinformatics analysis carried chemotaxis clinical symptom Clinical symptoms Combination component Corona COVID-19 CSF2 database disease docking effective gene target GeneCard hydrogen bonds immune response Immunity IMPROVE Inflammation inflammatory cell Inflammatory factor Inflammatory response ingredient inhibiting Intersection KEGG Lymphocytes mechanism mechanism of action molecular molecular docking molecular dynamics monomer NLRP3 Pachypodol pandemic Patient platform Protein protein targets radius of gyration reduce Research residue SARS-COV-2 infection screened signaling pathway significantly solvent stability targets TCMSP database therapeutic treating COVID-19 Treatment was used White blood cell Xuanfei Baidu granule [DOI] 10.3389/fcimb.2022.965273 PMC 바로가기