Conformational ensemble of the full-length SARS-CoV-2 nucleocapsid (N) protein based on molecular simulations and SAXS data분자 시뮬레이션 및 SAXS 데이터를 기반으로 한 전장 SARS-CoV-2 뉴클레오캡시드(N) 단백질의 구조적 앙상블Article Published on 2022-09-012022-09-11 Journal: Biophysical chemistry [Category] COVID19(2023년), SARS, 치료법, [키워드] average conditions conformation conformational conformations Contact dimer domain domains Each EROS exhibit experiment fluctuation full-length full-length SARS-CoV-2 gyration hydrophobic intrinsically knowledge Molecular simulation NMR nonspecific nucleocapsid nucleocapsid protein offer Protein radius of gyration Region SARS-CoV-2 SARS-CoV-2 virus SAXS. Structure structures the SARS-CoV-2 virus while X-ray scattering α-helix [DOI] 10.1016/j.bpc.2022.106843 PMC 바로가기 [Article Type] Article
Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separationArticle Published on 2022-09-012022-11-16 Journal: Protein Science : A Publication of the Protein Soc [Category] SARS, 변종, [키워드] activity acute respiratory syndrome addition affected change coronavirus COVID-19 infections decrease droplet engage Genome genomic RNA host infection induce intrinsically liquid-liquid phase separation modulating molecular Mutation N-terminal N-terminus NMR nucleocapsid protein nucleocapsid protein. omicron phosphorylated post-translational modification Protein Replication RNA RNA concentration SARS-CoV-2 Structural properties the SARS-CoV-2 Transcription undergo variant viral replication virions [DOI] 10.1002/pro.4409 PMC 바로가기
NMR spectroscopy spotlighting immunogenicity induced by COVID-19 vaccination to mitigate future health concernsReview article Published on 2022-08-222022-10-05 Journal: Current Research in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] affected Analysis approach BALF biological samples Biomarker Blood breast milk Bronchoalveolar-lavage fluid cerebrospinal fluid chemometrics complex COVID-19 COVID-19 vaccination CSF described detect disease examined example explain Health immunogenicity IMPROVE management metabolome mitigate molecular NMR NMR spectroscopy nuclear Nuclear magnetic resonance spectroscopy PCA Saliva Semen statistical the disease Treatment Urine vaccination Vaccine [DOI] 10.1016/j.crimmu.2022.08.006 [Article Type] Review article
Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approachSARS-COV-2에 대한 내생 세균의 2차 대사 산물의 생리 활성 가능성: In-silico 접근Article Published on 2022-08-042022-09-11 Journal: PLoS ONE [Category] SARS, 치료기술, 치료제, [키워드] 3CLpro accelerate accession number aligned ammonia analyses Analysis analyzed antioxidant approach associations Bacillus Bacteria Bacterial biochemically chymotrypsin Chymotrypsin-like protease collected Compound computational tool coronavirus Culture docked docking scores drug-likeness effective enzyme flask culture flavonoid GenBank identify in silico analysis in-silico inhibitor Interaction isolate Lopinavir metabolite metabolites Micrococcus morphologically nine NMR nucleotide nucleotide sequence outcome performed phytohormone plant profiles protease protein-protein network protein-protein networks protocol Pseudomonas species rDNA reported Research Sanger sequencing Secondary Metabolite sequence similarity Staphylococcus structures submission target protein target proteins tested these compounds was performed were assessed [DOI] 10.1371/journal.pone.0269962 PMC 바로가기 [Article Type] Article
SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregationSARS-CoV-2는 스트레스 과립의 분해를 손상시키고 ALS 관련 아밀로이드 응집을 촉진합니다Article Published on 2022-08-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 addition aggregation bind Cell cells cellular clearance experiment FUS Host host cells impair in vitro incorporation increased risk indicate infect Infection interactions Invasion mammalian cell mammalian cells Mutation N protein neurodegeneration NMR non-specific nucleocapsid nucleocapsid protein occur phase transition promote Protein Proteins reported SARS-CoV-2 SARS-COV-2 infection scenario stimulated Stress stress granule stress granule. stress granules [DOI] 10.1007/s13238-022-00905-7 PMC 바로가기 [Article Type] Article
Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8 + T Cell Response in HLA-A Transgenic MiceSARS-CoV-2의 엑소좀 백신 로딩 T 세포 에피토프 펩티드는 HLA-A 형질전환 마우스에서 강력한 CD8 + T 세포 반응을 유도합니다Article Published on 2022-07-292022-09-11 Journal: International journal of nanomedicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjuvant Administered CD8 control group Coronavirus-2 current elicited epitope epitope peptide Ex vivo exosomal vaccine Exosome Exosomes fold followed by fraction frequencies Frequency fused generate HLA-A human leukocyte antigen human leukocyte antigen-A IFN-γ induce injected intracellular cytokine staining leukocyte mice Modification Neutralizing antibodies neutralizing antibody NMR nuclear nuclear magnetic resonance organ toxicity peak peptide peptides purification purified response robust SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly subcutaneously T cell T cell response T cell responses T cells the SARS-CoV-2 virus the severe acute respiratory syndrome coronavirus-2. transgenic mice transmission electron microscopy Vaccine vaccine group western blotting wild-type [DOI] 10.2147/IJN.S367494 PMC 바로가기 [Article Type] Article
NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA EncounteringNMR은 RNA 조우에 관여하는 SARS-CoV-2 뉴클레오캡시드 단백질의 본질적으로 무질서한 영역 내의 특정 경로를 나타냅니다Article Published on 2022-07-022022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence atomic binding domain concert COVID-19 Disordered domain engage event experiments genomic RNA identify IDP information Interaction intrinsically N-terminal NMR NMR spectroscopy NTD organized primary sequence priming Protein Region Regulatory RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA SARS-CoV-2. Specific the SARS-CoV-2 tract Transcription [DOI] 10.3390/biom12070929 PMC 바로가기 [Article Type] Article
1H qNMR-Based Metabolomics Discrimination of Covid-19 SeverityArticle Published on 2022-07-012023-07-09 Journal: Journal of Proteome Research [Category] COVID19(2023년), [키워드] COVID-19 metabolomics NMR Prognosis. [DOI] 10.1021/acs.jproteome.1c00977 PMC 바로가기
Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal DomainSARS-CoV-2 뉴클레오캡시드 단백질 N-말단 도메인의 원자 분해능 구조Article Published on 2022-06-152022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] addition approach atomic bind binding experiment flexible genome organization genomic RNA Guidance in viral Infection information inhibitor means N- and C-termini N-terminal domain NMR NTD nucleocapsid offer pathogenicity Protein provide Region Replication RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus structural protein structural proteins Structure the SARS-CoV-2 the SARS-CoV-2 virus therapeutic intervention therapeutic interventions Vaccine development X-ray diffraction [DOI] 10.1021/jacs.2c03320 PMC 바로가기 [Article Type] Article
Molecular docking-assisted investigation of Pd(II) complexes carrying “SNS” pincer-type pyridine-thioether ligand as potential drug candidates against COVID-19Research article Published on 2022-06-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis atomic level binding binding affinity binding energy biochemical characterized complexes Compound coronavirus coronavirus 2 coronavirus disease COVID-19 defined docking drug candidate effective Efficiency Examining exhibit exhibited highest in silico Interaction Ligand metal complexes molecular docking NMR pandemic Pincer produced protease Protein provide public health RdRP respiratory RNA SARS-CoV-2 SARS-CoV-2 proteins Structure supported target protein targets the SARS-CoV-2 visual method [DOI] 10.1016/j.compbiomed.2022.105512 [Article Type] Research article