Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection
인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다
Research Article
[키워드] abrogated
abundance
ACE2
ACE2 protein
ACE2 sequence
Affect
allele
bind
binding
biochemical
Cell
cell line
cell surface
cells
change
coding
coronavirus
coronavirus spike proteins
correlated
CoV spike proteins
Cross-species transmission
Cytopathic effect
cytopathic effects
determine
Effect
Efficiency
engage
events
exomes
expressed
expression
fraction
Genetic
genomic integration
HEK 293T
Human
human ACE2
human Ace2 protein
implication
infect cells
Infection
inhibited
Interaction
Missense
missense mutants
Modification
mutant
mutants
N501Y
Non-linear relationship
nucleotide
overlapping
parental
promote
Protein
pseudotyped lentivirus
pseudovirus entry
pseudovirus infection
Quantitative
receptor protein
reduced
reducing
reference sequence
SARS-CoV
SARS-CoV entry
SARS-CoV-2
SARS-CoV-2 RBD binding
SARS-CoV-2 replication
SARS-CoV-2 spike
SARS-CoV-2 spike proteins
SARS-CoV-2 spike variants
SARS-like coronavirus
SARS-like coronaviruses
sequence
single nucleotide
Spike protein
Spike proteins
susceptibility
susceptibility to infection
target cell
target cells
the cell
the spike protein
transgenic
unique
variant
variants
Viral
viral spike
virus
viruses
while
zoonotic
[DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article