non-toxic
[용어속성] Term
Ferristatin II Efficiently Inhibits SARS-CoV-2 Replication in Vero Cells
Brief Report
[키워드] A significant reduction
ACE2
acute respiratory syndrome
affected
block
CD147
Cell
Concentration
confocal microscopy
consequence
coronavirus
COVID-19
Culture
D614G
Degradation
Delta
demonstrated
distribution
domain
ferristatin II
global public health
host cells
induce
Infection
inhibited
mechanism
medium
Multiple
Neuropilin-1
non-toxic
omicron
Protein
RBD
RBD protein
receptor
Receptor-binding domain (RBD)
replication of SARS-CoV-2
SARS-CoV-2
SARS-CoV-2 cell
SARS-CoV-2 host cell
SARS-COV-2 infection
SARS-CoV-2 receptors
SARS-CoV-2 variant
significantly
spike
the SARS-CoV-2
therapeutic strategy
Transferrin
transferrin receptor 1
Treatment
Vero
Vero Cell
Vero cells
viability
viral entry
virus
virus inhibition
Wuhan
[DOI] 10.3390/v14020317 PMC 바로가기 [Article Type] Brief Report
[DOI] 10.3390/v14020317 PMC 바로가기 [Article Type] Brief Report
Cytotoxic T-Cell-Based Vaccine against SARS-CoV-2: A Hybrid Immunoinformatic Approach
Article
[키워드] 3D structure
acquired immunity
administration
Antigen
Antigen presentation
binding
Cancer immunotherapy
canonical
cellular
cellular immunity
characterized
Coverage
COVID-19 convalescent patient
cytotoxic
cytotoxic T lymphocytes
dendritic cells
epithelia
epitope
Epitopes
highest
HLA
HLA class I
hybrid
IEDB
immune protection
immune response
immune stimulation
immunization
immunogenic
immunoinformatics
in silico
In silico methods
intranasal
long term immunity
molecular docking
Molecular docking study
NetMHCpan
non-allergenic
non-toxic
parameter
peptide
platform
Population
positive
Probability
protein folding
provide
provided
robust
SARS-CoV-2 T-Cell vaccine
screened
stimulate
Structure
synthetic long peptide
T-cells
Toll-like receptor
Toxicity
vaccination
VaxiJen 2.0
Viral mutations
virus clearance
[DOI] 10.3390/vaccines10020218 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/vaccines10020218 PMC 바로가기 [Article Type] Article
Molecular Docking and Dynamics Studies to Explore Effective Inhibitory Peptides Against the Spike Receptor Binding Domain of SARS-CoV-2
Molecular Biosciences
[키워드] acute respiratory syndrome
addition
affected
Against
allergenicity
antimicrobial peptide
binding
binding energy
binding free energy
calculate
complexes
coronavirus
deviation
docked
docking
docking result
docking scores
domain
drug candidate
Dynamics
effective
exacerbated
fluctuation
Future
Health
host cell
HPEPDOCK
Hydrogen bond
in vitro
in vivo
inhibit
lack
molecular
molecular dynamics
mortality rate
non-allergenic
non-toxic
pandemic
peptide
peptide-protein docking
peptides
predicted
radius of gyration
RBD
RMSD
RMSF
SARS-CoV-2
selected
Spike protein
Spread
suggested
the RBD
the SARS-CoV-2
the Spike
Toxicity
Transmission
Vaccines
virus
[DOI] 10.3389/fmolb.2021.791642 PMC 바로가기 [Article Type] Molecular Biosciences
[DOI] 10.3389/fmolb.2021.791642 PMC 바로가기 [Article Type] Molecular Biosciences
Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition
SARS-COV-2 RNA 의존 RNA 폴리머 라제 알로 스테 릭 부위 억제의 계산 연구
Article
[키워드] (RdRp)
Absorption
active site
active sites
allosteric site
Analysis
association
caused
Concentration
Contact
Course
COVID-19 pandemic
Dependent
disease
distribution
docked
Efficacy
enzyme
excretion
fatality
flavonoids
high mutation rate
high mutation rates
identify
information
inhibition
inhibitor
intestinal
intestinal absorption
metabolism
molecular docking
Mutation rates
myricetin
naringoside
new strain
non-toxic
offer
provided
RdRP
RNA
RNA dependent RNA polymerase
RNA polymerase
SARS-CoV-2
SARS-CoV-2 RdRp
SARS-CoV-2 RNA
SARS-CoV-2 virus
Simulation
Site
the SARS-CoV-2
the SARS-CoV-2 virus
Toxicity
Vaccine
Viral
[DOI] 10.3390/molecules27010223 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/molecules27010223 PMC 바로가기 [Article Type] Article
Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection
Article
[키워드] Abstract
approved
astrocytes
calu-3 cells
Cell Biology
cell entry
cellular entry
Chemistry
Compound
COVID-19
COVID-19 outbreak
entry of SARS-CoV-2
global public health
HEK293T cells
human cell
human cells
human lung
identify
Infection
inhibit
inhibitor
inhibitors of SARS-CoV-2
Neuron
non-toxic
Pandemics
Prevent
pseudotyped
pseudotyped SARS-CoV-2
Q34
related virus
safety profile
SARS-CoV-2
SARS-COV-2 infection
screened
small molecule
Toxicity
treated
uninfected cell
Virology
[DOI] 10.1016/j.isci.2021.103684 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.isci.2021.103684 PMC 바로가기 [Article Type] Article
Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors
강력한 SARS-CoV-2 주요 단백질분해효소 억제제로서의 주글론 및 그 유도체의 발견
Article
[키워드] acetyl
active site
Amino acid
amino acid residue
Analysis
antiviral activity
caused
Characteristics
characterized
Concentration
concentrations
contributed
coronavirus
COVID-19
demonstrated
derivative
Drug discovery
Efficacy
enzyme
evaluated
exhibited
Host
host cells
hydrogen
Hydrogen bond
hydrogen bonds
hydrolysis
in vitro
ingredient
inhibit
inhibitor
inhibitors
inhibitory
inhibitory activity
Juglone
M pro
M(pro) inhibitors
molecular docking studies
much higher
naphthoquinone
Naphthoquinones
non-toxic
outbreak
peptide
polyprotein
positive control
positive-sense single-stranded RNA
protease
proteinase
Replication
replication of SARS-CoV-2
Research
RNA coronavirus
SARS
SARS-CoV-2
significantly
suppress
tested
Transcription
Vero E6
Vero E6 cell
VERO E6 cells
Viral
virus
[DOI] 10.1016/j.ejmech.2021.113789 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.ejmech.2021.113789 PMC 바로가기 [Article Type] Article
Repurposing the inhibitors of COVID-19 key proteins through molecular docking approach
Research article
[키워드] active site
acute respiratory syndrome
ADME
Adsorption
approach
Benazepril
binding affinity
can be used
coronavirus
COVID-19
distribution
docking
drug
Drug suitability
drug targets
drugs targeting
effective
evaluate
evaluated
Health
identify
in viral
inhibitor
involved
metabolism
Moexipril
molecular
molecular docking
MPro
non-toxic
potential therapeutic agent
predict
protease
Protein
RdRP
Replication
repurposing
RNA virus
RNA-dependent RNA polymerase
spike glycoprotein
structural proteins
survival
therapeutic
therapeutic targets
Trandolapril
Treatment
virus
was used
[DOI] 10.1016/j.procbio.2021.08.015 [Article Type] Research article
[DOI] 10.1016/j.procbio.2021.08.015 [Article Type] Research article
Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and Mortaparib Plus
Mortaparib 및 Mortaparib Plus의 항 -CovID-19 전위에 대한 계산 및 시험 관내 실험 분석
Biophysics
[키워드] ACE2
activities
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Analysis
angiotensin
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
Antiviral assays
antiviral drug
attenuate
bind
cancer biology
candidate
Candidates
catalytic
caused
Cell
cell surface receptor
Compound
computational analysis
Computational biology
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
dose
down-regulate
down-regulation
dual
expression
health emergency
host cell
host cell surface
host cells
identify
implicated
in vitro
independent
Infection
inhibitor
inhibitory activity
M pro
measure
mechanisms
Mortaparib
non-toxic
pandemic
PARP
predicted
protease
Protein
receptor
Replication
respiratory
SARS-CoV-2
SARS-CoV-2 main protease
screened
Serine
serine 2
severe acute respiratory syndrome Coronavirus
Small molecules
TMPRSS2
transmembrane protease serine 2
treated
Vaccine
Viral
virus
[DOI] 10.1042/BSR20212156 PMC 바로가기 [Article Type] Biophysics
[DOI] 10.1042/BSR20212156 PMC 바로가기 [Article Type] Biophysics
Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells
Pharmacology
[키워드] accompanied
Affect
Anti-inflammatory
Antiviral
antivirals
assessment
Calu-3
Calu-3 cell
candidate
CCL5
CD40L
cell line
cellular entry
chemokine
clinical study
comparable
Concentration
coronavirus
CoV
COVID-19
COVID-19 therapeutics
CXCL10
CXCL9
cytokine
cytokine secretion
Cytokine storm
derivatives
disease
drug
Duration of infection
Effect
elevated
exhibited
Extract
fraction
growth
growth factor
highly pathogenic
Human
human lung
IC50
IL-13
IL-1β
IL-6
IL-8
IL1B
IL6
immune
immunomodulatory function
immunomodulatory properties
in vitro
in vivo
Inflammatory response
inhibited
inhibiting
innate immune response
MERS-CoV
modulation
non-toxic
oligomerization
Particle
PDGF
Pelargonium
pelargonium root extract (EPs® 7630)
Phytomedicine
Post-infection
pro-inflammatory cytokine
pro-inflammatory gene
Prodelphinidin
pseudovirus
purine
reduced
reducing
Regulation
root
SARS-CoV
SARS-CoV-2
SARS-CoV-2 entry
SARS-CoV-2 propagation
separated
shown
significantly
symptom severity
TNF-α
TNFAIP3
upper respiratory
upregulation
Viral load
viruses
[DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology
[DOI] 10.3389/fphar.2021.757666 PMC 바로가기 [Article Type] Pharmacology