Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2Article Published on 2022-10-212022-11-15 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antivirals Combination cysteine cysteines effective epitope human host inhibit Interaction iterative methodology N-terminal novel peptide peptides potent Protein RBD reaction receptor Receptor binding domain SARS-CoV-2 Selection spike the SARS-CoV-2 the Spike Vero E6 cell virus were used [DOI] 10.1021/acschembio.2c00565 PMC 바로가기
A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a PartArticle Published on 2022-10-182022-11-15 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome All adverse event Asymptomatic baseline clinical coronavirus coronavirus disease COVID-19 Culture demonstrated double-blind Efficacy and safety ensitrelvir fumaric acid greater group groups intention-to-treat population Japan Japanese log median time Mild Mild-to-moderate moderate multicenter novel oral Part Patient phase phase 2/3 Placebo positive Primary outcome proof-of-concept study protease Protease inhibitor Randomized receive reduced registry Result S-217622 SARS-CoV-2 SARS-CoV-2 3C-like protease inhibitor SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral the SARS-CoV-2 tissue Treatment viral clearance Viral RNA viral titer viral titer. [DOI] 10.1128/aac.00697-22 PMC 바로가기
Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy AdultsArticle Published on 2022-10-182022-11-15 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL acid administration adverse event affected agent Antiviral assessment AUC C max COVID-19 demonstrated dose doses drug-drug interaction Effect ensitrelvir first-in-human Food Intake geometric increase in Infection inhibitor Japanese mild in severity MOST novel oral dosing P450 participant Participants participants with SARS-CoV-2 pharmacokinetics phase 1 study Placebo plasma proportionality protease Protease inhibitor protease inhibitor. Randomized reduced resolved Safety SARS-CoV-2 selective single dose substrate T max Tolerability Treatment viral replication [DOI] 10.1128/aac.00632-22 PMC 바로가기
Development of a low-cost multi-channel nucleic acid detection PCR instrument and clinical detection application of COVID-19Article Published on 2022-10-092022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] amplification COVID-19 COVID-19 outbreak development disadvantage Double channel experiment hospital Low-cost novel Novel coronavirus Nucleic acid detection optical PCR Quantitative quantitative PCR quantitative PCR instrument Real-time fluorescence quantitative PCR. variety were used [DOI] 10.1016/j.aca.2022.340338 PMC 바로가기
Are the Current Processes and Regulations Fit for Purpose to Deliver Novel Therapies During Pandemics? A Perspective on COVID-19 from the UKArticle Published on 2022-10-012022-11-16 Journal: Pharmaceutical medicine [Category] 신약개발, [키워드] activities adaptive approval arise contribute country COVID-19 COVID-19 pandemic current develop Dexamethasone ENhance flexible Health involved lesson Medicines multi-arm novel Pandemics question rare diseases RECOVERY trial reduce Regulation Regulatory regulatory pathways shown Stress therapy Trial trials UK Medicine United Kingdom urgency [DOI] 10.1007/s40290-022-00439-7 PMC 바로가기
High prevalence of SARS-CoV-2 detection and prolonged viral shedding in stools: A systematic review and cohort studyArticle Published on 2022-10-012022-11-15 Journal: Gastroenterología y hepatología [Category] COVID19(2023년), SARS, 치료기술, [키워드] 2019-nCoV-2 age association children clearance clearance of SARS-CoV-2 Cohort cohort of patient cohort study collected conducted coronavirus COVID-19 detect detectable detection Diarrea diarrhea English female Frequency gastrointestinal symptoms heterogeneity infected with SARS-CoV-2 Kaplan-Meier Kaplan-Meier curves male media median meta-regression nasopharyngeal Nasopharyngeal swab novel Novel coronavirus Nuevo coronavirus Patient patients performed Prevalence prolonged viral shedding prospective cohort study random-effects model reported SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 infected patient SARS-CoV-2. severity Spanish Stool stools systematic review Viral detection Viral RNA [DOI] 10.1016/j.gastrohep.2021.12.009 PMC 바로가기
Novel Zoonotic Avian Influenza A(H3N8) Virus in Chicken, Hong Kong, ChinaArticle Published on 2022-10-012023-06-14 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza virus chicken China emergence H3N8 Hong Kong Human Immunity Influenza Influenza virus novel Population respiratory infections serology viruses zoonoses. [DOI] 10.3201/eid2810.221067 PMC 바로가기
Novel in-home COVID-19 vaccination program for vulnerable populations using public-private collaborationArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] analyzed Care Characteristics collected Course COVID-19 COVID-19 vaccination described disease transmission effort evaluate female forms Health health condition high-risk population highlight in-home care increased risk indicated less median age MOST motivation New York novel Older Older adults outcome outcomes Population populations receiving recipient recipients reduce reflected reported risk severe COVID-19 disease statistical significance USA vaccination Vaccinations Vaccine variant vulnerable populations. [DOI] 10.3389/fpubh.2022.898787 PMC 바로가기
Variant-Specific Analysis Reveals a Novel Long-Range RNA-RNA Interaction in SARS-CoV-2 Orf1aArticle Published on 2022-09-212022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 receptor Affect aggregate analyses analysis Beta binding affinity change changes compensatory mutations COVID-19 COVID-19 pandemic de novo Evidence feature human lung cell identify in silico in vivo information Interaction knowledge novel pathogenicity pathology Protein recent researchers RNA RNA structure RNA virus RNA-RNA interaction RNA-RNA interactions SARS-CoV-2 SARS-CoV-2 sequences sequence spike statistical the SARS-CoV-2 the SARS-CoV-2 genome variant viral evolution viral evolution. viral pathogenicity viral variant virus [DOI] 10.3390/ijms231911050 PMC 바로가기
Scars of COVID-19: A bibliometric analysis of post-COVID-19 fibrosisArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Public Health [Category] SARS, 치료기술, [키워드] acute injury Analysis analyzed article changed Cluster collected Comorbidities coronavirus 2 coronavirus disease country COVID-19 COVID-19 pandemic Cystic database Diagnosis early phase English enrolled Epidemiology etiology Evidence experiment fibrosis French hotspot hotspots and trends Imperial College London Increasing individual level Infection international cooperation intrinsic investigated journal Laboratory Lung function material novel Pathogenesis Patient professional promote public health threat Quality of life Research reversed Spread Therapies therapy Therapy. university University of Washington USA vaccination Volume was performed Web of Science [DOI] 10.3389/fpubh.2022.967829 PMC 바로가기