Multimodal CTC detection using stem cell antigen-specific immunosilica particles and immunofluorescent quantum dots Research Published on 2022-01-142022-10-05 Journal: NPG Asia Materials [Category] 바이오마커, 유전자 메커니즘, [키워드] addition Antigen Blood blood sample Cancer cancer cell Cell cells circulating COVID-19 pandemic detect detection efficiency disease Follow-up highlight liquid Lungs molecular noninvasive nuclei Particle resolved therapeutic tumor cell [DOI] 10.1038/s41427-021-00353-5 [Article Type] Research
The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegansArticle Published on 2022-01-102022-10-04 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 치료제, [키워드] Activation Caenorhabditis Caenorhabditis elegan Control Defense downstream elegan ENCODE expressed function fungal pathogens Gene Expression Host Host transcriptional response hosts immune response induce infect Infection Infectious diseases Innate immunity intestinal intestinal cells intestine invertebrate less molecular Molecular biology nuclei pathogen promote Protective Protein regulatory pathways required resistance to infection RNA virus subset transcription factor Trigger virus [DOI] 10.1038/s41467-021-27621-w PMC 바로가기 [Article Type] Article
Inflammasome activation in neutrophils of patients with severe COVID-19Research article Published on 2022-01-062022-10-05 Journal: Blood advances [Category] COVID19(2023년), SARS, 변종, [키워드] Activation acute respiratory syndrome ASC coronavirus correlation COVID-19 COVID-19 patient demonstrated engage fluorescent form human disease implicated induce Inflammasome inflammasome activation Inflammation leukocytes Macrophage mice Microscopy microtubule organizing center monocyte NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils NLRP3 inflammasome nuclear nuclei nucleus pathogenesis of COVID-19 Patient Peripheral blood positive Protein reporter Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient stimulated the cytokine storm tracheal aspirate [DOI] 10.1182/bloodadvances.2021005949 [Article Type] Research article
Cytopathological Findings in Bronchoalveolar Lavage from Patients with COVID-19Article Published on 2022-01-012022-11-15 Journal: Acta cytologica [Category] 진단, [키워드] addition addressed alveolar Analysis Atypical BAL bronchial cell Bronchoalveolar lavage Cell cellular change changes Characteristics clearance clinically collected COVID-19 cytopathic Cytopathic effect Cytopathological finding. cytoplasmic described evaluated finding increase in Inflammatory information lavage leukocyte lymphocyte Macrophage macrophages malignancy molecular multinucleated giant cell multinucleated giant cells Nasopharyngeal swab neutrophilic nuclear nuclear chromatin nuclei pathological change pathological changes patients patients with COVID-19 Peripheral blood pneumocyte Pneumonia reactive reported Research respiratory tract suspected patient virus with COVID-19 [DOI] 10.1159/000525339 PMC 바로가기
Partial structure, dampened mobility, and modest impact of a His tag in the SARS-CoV-2 Nsp2 C-terminal regionOriginal Article Published on 2021-10-112022-10-31 Journal: European Biophysics Journal [Category] COVID-19, SARS, [키워드] assigned atomic level backbone C-terminal cleavage conformational conformations cryo-EM Defense eukaryotic cells flexible Host human protein information interact Interaction Intrinsically disordered proteins molecule N-terminal NMR spectroscopy not affect NSP2 nuclei Partial physiological predicted preference promote Protein Region regulate residues SARS-CoV-2 supplementary material targets the SARS-CoV-2 translation initiation Vesicle viral growth virus while X-ray crystallography [DOI] 10.1007/s00249-021-01575-9 PMC 바로가기 [Article Type] Original Article
COVID-19 is associated with distinct myopathic features in the diaphragm of critically ill patientsCOVID-19는 중환자의 횡격막에 있는 뚜렷한 근병증 특징과 관련이 있습니다.Article Published on 2021-09-012022-09-12 Journal: BMJ Open Respiratory Research [Category] 진단, [키워드] Autopsy average Clinical outcome collected contribute COVID-19 COVID-19 infection Critically ill patient critically ill patients cross-sectional area Deceased Diaphragm died differentially expressed gene dysfunction Dyspnoea fatigue feature fibrosis Gene Expression infiltration involved muscles Myofiber myofibers myopathic Netherland nuclei Patient reported respiratory muscles. RNA-sequencing SARS-CoV-2 specimen splitting the patient with COVID-19 [DOI] 10.1136/bmjresp-2021-001052 PMC 바로가기 [Article Type] Article
Multi-Organ Histopathological Changes in a Mouse Hepatitis Virus Model of COVID-19Article Published on 2021-08-272022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] alveolar animal model Asymptomatic Blood blood vessels Brain bronchiolar capillary cause Cell change changes characterized cortical COVID-19 COVID-19 pandemic Cytokine storm death distal edema epithelial hemorrhage Hemorrhagic Hepatitis Human humans hyaline membrane formation infect Infection infiltration inoculated interstitial interstitial tissue intra-alveolar liver macrophages mechanism mice Mild Model moderate mononuclear cell mouse mouse hepatitis virus-1 multiorgan histopathology Necrosis necrotic necrotic debris Neuron nuclei organ system oxidative stress pathophysiologic peribronchiolar perivascular Pneumonia precipitated red blood cells renal reported representing Respiratory illness responsible Safe SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection Septic shock severe lung inflammation severe symptom therapeutic interventions thrombosis thrombotic event Tubular Necrosis uninfected vascular congestion vascular defect vessels virus was used weight loss widespread [DOI] 10.3390/v13091703 PMC 바로가기 [Article Type] Article
East Asian climate response to COVID-19 lockdown measures in China중국의 COVID-19 잠금 조치에 대한 동아시아 기후 대응Article Published on 2021-08-192022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] Air pollution amplified anthropogenic atmospheric atmospheric condition atmospheric conditions Atmospheric science caused changes in China Climate Climate sciences cloud condensation nuclei COVID-19 COVID-19 pandemic detectable earth East Asian emission Emissions experiment generate in some Interaction life lockdown measure mechanisms Model nuclei observations offset perturbations physical promote reduced reduction sensitivity System Version weather [DOI] 10.1038/s41598-021-96007-1 PMC 바로가기 [Article Type] Article
Effects of Air Purifiers on the Spread of Simulated Respiratory Droplet Nuclei and Virus AggregatesCommunication Published on 2021-08-102022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] affected aggregate aggregates Air purifier changes in Concentration COVID-19 droplet Effect evaluate the effect exceeded experiment HEPA filter not significant nuclei Particle Purifier reduced respiratory respiratory droplet nuclei Safe significantly Spread spread of COVID-19 Transmission vibrating mesh nebulizer virus virus aggregates was performed were measured [DOI] 10.3390/ijerph18168426 PMC 바로가기 [Article Type] Communication
The Immunopathogenesis of Neuroinvasive Lesions of SARS-CoV-2 Infection in COVID-19 PatientsNeurology Published on 2021-07-302022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] addition Brain cause cell death CNS consequence COVID-19 COVID-19 virus Cytokine storm death disease dysregulation Effect Effects IL-6 induce Infection Inflammation initial lesion mechanism mild infection neuroinvasive lesions neurological neuronal New coronavirus nuclei olfactory progression recent finding regulate reported SARS-CoV-2 SARS-CoV-2- Spread subject Transport virus [DOI] 10.3389/fneur.2021.697079 PMC 바로가기 [Article Type] Neurology