Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactionsArticle Published on 2022-09-082022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accompanied Activation animal model bioinformatics cells characterized chemokine COVID-19 COVID-19 patients E protein expression Extracellular matrix immune immune response immunological immunomodulatory property Inflammation Interaction intrinsic kinases lipid metabolism Loss of Smell machine metabolic molecular multifunctional olfactory Protein proteome proteomic proteomics receptor reveal SARS-CoV-2 secretion Signaling Smell structural protein survival Symptom TGF-beta signaling the SARS-CoV-2 These data trajectory transcriptomics transcriptomics. tyrosine virion widespread [DOI] 10.3389/fimmu.2022.866564 PMC 바로가기
In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variantsArticle Published on 2022-09-052022-11-16 Journal: Acta Neuropathologica Communications [Category] SARS, 변종, [키워드] acute phase acute respiratory syndrome astrocytes B.1.1.529 B.1.617.2 Brain olfactory bulb Cell CNS co-cultured coronavirus cortical COVID-19 Culture D614G days post infection Delta hamster hamsters in vitro in vivo in vivo models Infection inoculated interferon isolate mechanism microglia activation mucosa Neuroinflammation neuroinvasion Neuroinvasive Neurological complications Neuron neurotropic neurotropism neurovirulence neurovirulent occur olfactory omicron performed reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. shown the SARS-CoV-2 variant [DOI] 10.1186/s40478-022-01426-4 PMC 바로가기
Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patientsRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: European archives of oto-rhino-laryngology : offic [Category] 임상, [키워드] Analysis Anosmia association Concentration COVID-19 COVID-19 adult patient COVID-19 patient Effect elevated enrolled functional healthy increase in intracellular calcium intranasal nasal olfactory olfactory disorders olfactory dysfunction patients worldwide Randomized controlled trial Research SARS-CoV-2 secretion selective significant decrease Smell Smell. Sodium chloride Symptom Treatment was performed [DOI] 10.1007/s00405-022-07424-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal StudyRandomized Controlled Trial Published on 2022-08-172022-10-05 Journal: Cells [Category] 임상, [키워드] absence affected age ameliorated Anosmia average baseline Biomarkers Brain brain fog Combination COVID COVID-19 disorders Effect group Hyposmia interval investigated Long long-haul COVID syndrome longitudinal lutein Luteolin measure mechanisms memory men Mental mental clouding Neuroinflammation Olfaction olfactory olfactory dysfunction olfactory threshold olfactory training outcomes palmitoylethanolamide parosmia Patient patients PEA-LUT Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Prevalence qualitative smell disorders Quantitative Randomized receive recruited reduction in regimen remaining group Result SARS-COV-2 infection self-report measure severity smell disorders. subjects subsequent therapy thresholds Treatment were assessed women [DOI] 10.3390/cells11162552 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19코로나19 사망자의 SARS-CoV-2 뇌 부위 검출, 조직병리학, 유전자 발현 및 면역조절 변화Article Published on 2022-08-162022-09-11 Journal: Journal of neuropathology and experimental neurolo [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] Amygdala arising Autopsies Autopsy Blood Brain brains cerebellar cortex change Control COVID-19 COVID-19 cases cytokine Deafferentation detection Differentially expressed genes downregulation Encephalitis fraction Gene Expression Genes Hemorrhagic hemorrhagic encephalitis Histopathology immune immune response indicated involved marker microglia mucosa neuronal Non-COVID-19 olfactory olfactory bulb portal receptor reduced reduction Region Regional RNA polymerase RNA sequence RNA sequences RNA-dependent RNA polymerase RNAseq RT-PCR S gene SARS-CoV-2 SARS-CoV-2 E gene SARS-CoV-2. sequence serum Significant subject upregulation viral sequence virus with COVID-19 [DOI] 10.1093/jnen/nlac056 PMC 바로가기 [Article Type] Article
COCOS trial: CO rticosteroids for CO VID-19-induced loss of S mell-protocol for a single-centred, double-blind, randomised, placebo-controlled trialCOCOS 시험: 단일 중심, 이중 맹검, 무작위, 위약 대조 시험을 위한 CO VID-19 유발 S mell-protocol 손실에 대한 CO rticosteroidsArticle Published on 2022-08-102022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] addition Anosmia approved center Corticosteroids COVID-19 COVID-19 diagnosis determine disorder disorders double-blind early phase Efficacy Ethics gustatory function High-dose Hyposmia hypothesised IMPROVE include Inclusion induce Infectious diseases Inflammation institutional review board local inflammatory response Loss of Smell matching placebo Most patient Most patients nasal olfactory olfactory function olfactory nerve otolaryngology OTOLARYNGOLOGY. outcome pathway Patient peer-reviewed persist Placebo placebo-controlled trial positive Prednisolone Primary outcome Quality of life Questionnaires randomised receive reduce registration number Research protocol secondary Secondary outcomes stick Symptoms Treatment Trial university [DOI] 10.1136/bmjopen-2021-060416 PMC 바로가기 [Article Type] Article
Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?정신 장애의 후각 장애: 비염이 질병 정신 생리학에 영향을 줍니까?Review Published on 2022-08-052022-09-11 Journal: Translational Psychiatry [Category] 유전자 메커니즘, [키워드] adverse effect Brain brain development cause Clinical studies clinical study contribute coronavirus disease Coronavirus disease 2019 COVID-19 Critical Depression disease environmental factor environmental factors Evidence followed by functions illness impairment Inflammation involved long-lasting Mental nasal Neuropsychiatric olfactory olfactory dysfunction olfactory function outbreak outcome pathophysiological mechanism pathophysiological mechanisms pathophysiology produced Psychiatric Psychiatric disorders Psychopathology recent Regulation Research respiratory viral infection respiratory viral infections risk Schizophrenia [DOI] 10.1038/s41398-022-02081-y PMC 바로가기 [Article Type] Review
Persistent olfactory dysfunction after COVID-19 is associated with reduced perfusion in the frontal lobeCOVID-19 이후 지속되는 후각 기능 장애는 전두엽의 감소된 관류와 관련이 있습니다Article Published on 2022-08-012022-09-11 Journal: Acta neurologica Scandinavica [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute infection analysis Anosmia association Brain Brain mapping brain region Central nervous system changes in conducted COVID-19 dysfunction evaluate identification labeling MRI nasal Neuroimaging olfactory olfactory dysfunction olfactory test paranasal Paranasal sinuses pathophysiology Patient performed persistence persistent post-COVID syndrome. reduced Region SARS-COV-2 infection sequence Smell statistically significant Symptom syndrome Test tissue tissue perfusion Volume Voxel were assessed White matter [DOI] 10.1111/ane.13627 PMC 바로가기 [Article Type] Article
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic micehACE2 형질전환 마우스에서 SARS-CoV-2 감염 후 시간적 뇌 병변Article Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis animal model astrogliosis Beta Brain cause Central nervous system Cerebellum characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop different time points distribution Encephalitis hACE2 hACE2-transgenic mice histopathological immunohistochemistry immunolabeling inoculation lesion meningoencephalitis mice mucosa necropsies necropsy Neuroinflammation Neurological disease neuronal neurons Neuropathology neuropathology. nonsuppurative olfactory other organ other organs panel of antibodies panel of antibody performed post inoculation processed question reached Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spongiosis Spread susceptible thrombosis transgenic mice vacuolar vacuolar degeneration variants Vasculitis virological assay virological assays virus [DOI] 10.1177/03009858211066841 PMC 바로가기 [Article Type] Article
Relationship between changes in symptoms and antibody titers after a single vaccination in patients with Long COVID장기 코로나 환자에서 1회 접종 후 증상 변화와 항체가와의 관계Article Published on 2022-07-012022-09-12 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abnormalities addressed antibody Antibody titer change changes in Coronavirus disease 2019 COVID COVID-19 enrolled evaluated excessive immune response fatigue first vaccination groups highest hospital joint Long Long COVID median men olfactory Pain Patient patients postvaccination Ratio relationship SARS-CoV-2 IgG significantly single vaccination Symptom vaccination Vaccine vaccine. were measured worsened worsening [DOI] 10.1002/jmv.27689 PMC 바로가기 [Article Type] Article