Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients기준선에서 가용성 IL-2R 수준은 COVID-19 환자에서 심각한 호흡 부전 및 사망의 발병을 예측합니다Article Published on 2022-04-102022-09-11 Journal: Viruses [Category] 바이오마커, [키워드] 95%CI Admission Algorithm Anakinra Biomarker change clinical outcomes coronavirus coronavirus disease Coronavirus disease-19 Corticosteroid Corticosteroids COVID-19 Critical cut-off Delta development died discharge disease severity Endpoint failure Follow-up hazard ratio Immunoglobulin Immunotherapy interquartile range Intravenous immunoglobulin Intubated intubation Laboratory Level Local local treatment marker median age moderate disease Mortality on admission Patient positive predict Predictive Predictive value receptor respiratory Respiratory failure risk Risk factors risk stratification severe disease severe respiratory failure significantly higher soluble interleukin-2 receptor SRF Stratification the strongest Tocilizumab Treatment were measured [DOI] 10.3390/v14040787 PMC 바로가기 [Article Type] Article
Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19세로형 플라즈마 단백질체학 분석, 급성 코로나19에서 새로운 후보 바이오마커 밝혀Article Published on 2022-04-012022-09-11 Journal: Journal of Proteome Research [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abundance ACEi acquisition Activation acute COVID-19 acute inflammatory response Admission amyloid Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors ARB baseline Blood blood plasma candidate cascade cell proliferation complement Complement activation COVID-19 COVID-19 patients decrease degranulation exposure to fluctuation followed by fructose functions healthy control healthy controls healthy individual healthy individuals host response humoral immune response Infection Inflammatory Inflammatory response inhibitors longitudinal longitudinal analysis mechanism mechanisms nonsurvivors novel on admission pathophysiology Patient patients Platelet profile Protein Proteins proteomic proteomics Quantitative Receptor Blockers Regulation smooth muscle survivor targeted quantitative proteomics. [DOI] 10.1021/acs.jproteome.1c00863 PMC 바로가기 [Article Type] Article
Prognostic factors for predicting severity and mortality in hospitalized COVID-19 patients입원한 COVID-19 환자의 중증도 및 사망률을 예측하기 위한 예후 인자Article Published on 2022-03-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, SARS, 바이오마커, [키워드] Admission ALT Analysis aPTT association Coagulation coagulation cascade coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient creatine creatine kinase death demonstrated determine disease severity early stage early stages Factor Final global pandemic hematocrit hospital hospitalized COVID-19 patient IMPROVE INR International Kingdom laboratory result Laboratory results Lactate lactate dehydrogenase Logistic regression lymphopenia management medical record medical records moderate moderate to severe Mortality multiple logistic regression on admission outcome Patient patients predict predictor prognostic public health emergency reached reduce mortality Retrospective analysis Saudi Arabia severe COVID-19 patient severity specific biomarker specific biomarkers the disease the WHO variable was performed [DOI] 10.1002/jcla.24216 PMC 바로가기 [Article Type] Article
Improvement of outcome prediction of hospitalized patients with COVID-19 by a dual marker strategy using high-sensitive cardiac troponin I and copeptin고감도 심장 트로포닌 I 및 코펩틴을 이용한 이중 마커 전략에 의한 COVID-19 입원 환자의 결과 예측 개선Observational Study Published on 2022-03-012022-09-11 Journal: Clinical Research in Cardiology [Category] SARS, 바이오마커, 임상, [키워드] 28-day mortality Admission Adverse adverse outcome Analysis association Biomarker Biomarkers c-statistics cardiac troponin Cardiac troponin I cardiovascular disease Care collected Combination composite endpoint conducted copeptin COVID-19 COVID-19 infection cut-off demonstrated eligible patient High-sensitive cardiac troponin I (hs-cTnI) hospital hospitalized patient hospitalized patients ICU admission improvement independent laboratory-confirmed marker morbidity Mortality multivariable logistic regression Multivariable logistic regression analysis myocardial injury observational study on admission outcome Patient Prevalence primary composite endpoint primary endpoint Prognostic marker Prognostic value raised reached risk risk marker ROC analysis significantly significantly higher tested the primary endpoint troponin I vasopressin with COVID-19 [DOI] 10.1007/s00392-021-01970-4 PMC 바로가기 [Article Type] Observational Study
Effectiveness of inactivated SARS-CoV-2 vaccine (CoronaVac) on intensive care unit survival중환자실 생존에 대한 비활성화된 SARS-CoV-2 백신(CoronaVac)의 효과Original Paper Published on 2022-02-092022-09-11 Journal: Epidemiology and Infection [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] Admission admitted to ICU arterial blood arterial blood gas Blood blood gas clinical CoronaVac coronavirus disease Coronavirus disease 2019 Course COVID-19 eligible enrolled evaluated ferritin ferritin level ferritin levels genetic variants group had no hospital Hospital mortality Hospital stay ICU inactivated intensive care intensive care unit investigated Laboratory Lactate lactate dehydrogenase Length Mortality National no effect not different on admission parameters Patient patients protective effect radiological Radiological parameters SARS-CoV-2 pandemic SARS-CoV-2 vaccine Sinovac survival target population vaccination vaccination schedule Vaccine [DOI] 10.1017/S0950268822000267 PMC 바로가기 [Article Type] Original Paper
Descriptive comparison of admission characteristics between pandemic waves and multivariable analysis of the association of the Alpha variant (B.1.1.7 lineage) of SARS-CoV-2 with disease severity in inner London전염병 파동 사이의 입원 특성과 SARS-COV-2의 알파 변이체 (B.1.1.7 계보)의 연관성 분석 및 런던 내부의 질병 중증도의 다변량 분석.Infectious Diseases Published on 2022-02-082022-09-10 Journal: BMJ Open [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] 1.26 95% CI Admission age aligned Alpha Alpha variant Analysis association B.1.1.7 B.1.1.7 lineage Characteristics circulating clinical Clinical data Cohort collected current defined disease severity dominant Electronic health record Epidemiology Health health record healthcare hospitalised hypoxia Infection infection control Intervention isolate Laboratory Logistic regression London multisite multivariable analysis Multivariate analysis nosocomial obesity on admission pandemic positive public health Result risk factor Risk factors SARS-CoV-2 SARS-CoV-2 RNA sequence sequenced severity Severity of disease variant Viral viral genome sequence Virology Wave [DOI] 10.1136/bmjopen-2021-055474 PMC 바로가기 [Article Type] Infectious Diseases
Role of Urinary Kidney Stress Biomarkers for Early Recognition of Subclinical Acute Kidney Injury in Critically Ill COVID-19 Patients중환자 COVID-19 환자에서 무증상 급성 신장 손상의 조기 인식을 위한 요로 신장 스트레스 바이오마커의 역할Article Published on 2022-02-082022-09-11 Journal: Biomolecules [Category] 바이오마커, [키워드] 95% CI acute kidney Acute kidney injury Admission AKI binding Biomarker Biomarkers clinical information clinical trials collected Combination Comorbidities concentrations contribute COVID-19 COVID-19 patient COVID-19 patients critical care area Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients develop Early detection Gender growth factor Hospitalization IGFBP7 Ill individual information insulin insulin like growth factor binding protein 7 kidney laboratory data longitudinal cohort study male Mortality neutrophil Neutrophil gelatinase-associated lipocalin on admission persistent proportion Protein Recognition risk factor Risk factors role significantly higher Stress study outcome study outcomes Subclinical Tissue Inhibitor tissue inhibitor of metalloproteinases-2 urinary urinary kidney stress biomarkers. were recorded with COVID-19 [DOI] 10.3390/biom12020275 PMC 바로가기 [Article Type] Article
Using dipstick urinalysis to predict development of acute kidney injury in patients with COVID-19COVID-19 환자에서 급성 신장 손상의 발병을 예측하기 위해 딥 스틱 소변 검사 사용Research Published on 2022-02-012022-09-01 Journal: BMC Nephrology [Category] MERS, 진단, [키워드] 95% confidence interval Accuracy Acute kidney injury added Admission AKI AUC baseline chronic Chronic kidney disease CKD COVID-19 creatinine Dipstick during admission help Hematuria hospitalized patient hospitalized patients hospitals incorporation increase increased risk individuals kidney Kidney disease Kidney injury on admission outcome patients patients hospitalized patients with COVID-19 PCR positive predict Predictive model predictive models Presence Prognostic value Proteinuria renal replacement therapy replacement therapy respiratory Result RRT SARS-CoV2 serum creatinine severity significantly increased supplementary material Urinalysis were used with COVID-19 [DOI] 10.1186/s12882-022-02677-y PMC 바로가기 [Article Type] Research
A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation입원 4일 후 입원한 Covid-19 환자의 사망률을 예측하는 모델: 개발, 내부 및 시간-외부 검증Cellular and Infection Microbiology Published on 2022-01-242022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] Admission age Alpha Alpha variant AUROC B.1.1.7 blood parameter C-reactive protein calibration slope Care characteristic clinical coronavirus COVID-19 creatinine cross Day develop development discharge explained Fever Final FIVE haematological parameter haematological parameters Health Health care Health care system Hospitalized hospitalized COVID-19 patients hospitalized patients hospitals Identifier in-hospital mortality internal Lactate lactate dehydrogenase linear mixed model Logistic regression Model Mortality mutations non-survivor Non-survivors objective Occurrence on admission parameter Patient Platelet Platelet count Prediction model prevalent prognostic model receiver operating characteristic receiver operating characteristic curve reduce Registration Result slope Support supported survival survivor validation variable variable selection variables Variation was done [DOI] 10.3389/fcimb.2021.795026 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Clinical Characteristics of COVID-19 Patients in a Regional Population With Diabetes Mellitus: The ACCREDIT Study당뇨병이있는 지역 인구에서 Covid-19 환자의 임상 적 특성 : 공인 연구Multicenter Study Published on 2022-01-132022-08-31 Journal: Frontiers in Endocrinology [Category] 바이오마커, [키워드] 30-Day mortality Admission advanced age age analyses Analysis analyzed biochemical blood glucose BMI Characteristics CKD clinical clinical and biochemical characteristics cohort study collecting data complications conducted COVID-19 CRP dataset death diabete diabetes Glucose glycaemic control greater higher risk hospital hospitalised identify insulin intensive care IQR lower risk Median BMI men Mortality Multivariate analysis multivariate logistic regression objective observational study occurred on admission Patient performed Population Predictive Primary outcome proportion random Regional remained required Research design resources Result Risk factors risk of death robust splitting type 2 diabete type 2 diabetes with COVID-19 younger patient younger patients [DOI] 10.3389/fendo.2021.777130 PMC 바로가기 [Article Type] Multicenter Study