A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19Article Published on 2021-11-252022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] affected amplifying antagonist anti-inflammatory agent anti-inflammatory response bind Cancer cause cirrhosis complex Corticosteroid COVID-19 Critical deregulation Dexamethasone disease Diseases expressed Factor gene expression level glucocorticoid HCC healthy subjects Hepatocellular carcinoma Human identify immunology IMPROVE Inflammation isoform knowledge liver Liver disease mice Molecular biology mRNA level NF-kB opposite p65 Patient PBMC physiological quantified receptor Regulation SARS-CoV-2 disease therapeutic target Transcription transcription factor transcription factors variant wild type [DOI] 10.1038/s41598-021-02119-z PMC 바로가기 [Article Type] Article
The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 ReplicationNF-κB 전사 발자국은 SARS-CoV-2 복제에 필수적입니다Article Published on 2021-11-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] absence Activation analysis Antiviral approach canonical caused characterized COVID-19 COVID-19 pandemic cytokine production Defense dependency develop Disruption driving effective antiviral treatment effective vaccine Effective vaccines effort Essential etiological agent Factor Footprint IFN-I IFN-I response in vitro infected cells inhibitors molecular basis morbidity Mortality new SARS-CoV-2 NF-κB NF-κB signaling P50 p65 product reduced rescued robust SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 replication SARS-CoV-2. screenings selective single-cell These data transcription factor transcription factors transcriptomic type I interferon variant viral replication virus replication [DOI] 10.1128/JVI.01257-21 PMC 바로가기 [Article Type] Article
Traditional Chinese Medicine, Qingfei Paidu Decoction and Xuanfei Baidu Decoction, Inhibited Cytokine Production via NF-κB Signaling Pathway in Macrophages: Implications for Coronavirus Disease 2019 (COVID-19) TherapyPharmacology Published on 2021-10-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] A549 cell A549 cells Activation addition analyzed anti-inflammatory activity Baidu Cell chemokine Chinese COVID-19 Cytokine storm Decoction defined demonstrated Efficacy ELISA evaluated expression expression level feature host immunity IFN IFN signaling pathway IFNα and IFNβ immune response in vitro infected with SARS-CoV-2 inhibited Innate immunity interferon-stimulated gene interleukin-6 investigated ISGs IκBα Ligand LPS Macrophage macrophage polarization macrophages marker mechanism Medicine modulation monocyte chemotactic protein-1 network pharmacology neutral red NF-κB signaling pathway NF-κB NF-κB signaling p65 pathway Patient PCR Phosphorylation pro-inflammatory pro-inflammatory cytokine Production Regulation robust RT-qPCR SARS-CoV-2 shown signaling pathway significantly suppressed THP-1 Traditional Traditional Chinese medicine treated Treatment tumor necrosis factor-α type 1 interferon were measured [DOI] 10.3389/fphar.2021.722126 PMC 바로가기 [Article Type] Pharmacology
Standardized Extract of Asparagus officinalis Stem Attenuates SARS-CoV-2 Spike Protein-Induced IL-6 and IL-1β Production by Suppressing p44/42 MAPK and Akt Phosphorylation in Murine Primary MacrophagesArticle Published on 2021-10-142022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Asparagus officinalis L. activating acute respiratory syndrome analyzed Asparagus attenuate attenuation Cell Cell signaling coronavirus coronavirus disease COVID-19 Degradation EAS Effect elicit enzyme-linked immunosorbent examined excessive inflammation Extract functional greater Host hydrogen peroxide IL-1β IL-6 induce Infection Inflammation inhibitor inhibitors Macrophage macrophages MAPK Mortality mRNA level N-terminal not affect nuclear nuclear translocation p65 patients with COVID-19 Phosphorylation polymerase chain pro-inflammatory cytokine pro-inflammatory response pro-inflammatory signaling Production Protein Proteins reducing reported reverse transcription S1 subunit SARS-CoV-2 secretion severity Signaling significantly Simultaneous treatment Skin fibroblasts spike Spike protein STEM subunit suppressed Suppressing the SARS-CoV-2 TLR4 toll-like receptor 4 Transcription ultraviolet unique viability were assessed [DOI] 10.3390/molecules26206189 PMC 바로가기 [Article Type] Article
Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin ConditionsOriginal Research Reports Published on 2021-08-012022-10-28 Journal: Stem cells and development [Category] COVID-19, MERS, SARS, [키워드] addition approach Calu-3 calu-3 cells chronic inflammation Comorbidity Concentration condition contribute contributed contributing to correlation COVID-19 COVID-19 patient Cytokine storm Diabetes Mellitus disease DM downregulation effort epithelial cell examined extracellular vesicle Extracellular vesicles Factor function Glucose human lung Jelly Meta-analysis Mortality MSCs NF-κB nuclear Organ failure outcome p65 Patient patients with COVID-19 Potential treatment RD reaction reduce renal Research SARS-CoV SARS-CoV-2 severe symptom severity of COVID-19 significant decrease STEM stem cell suggested systematic review the cytokine storm toxin toxins uremic viral infection was increased [DOI] 10.1089/scd.2021.0065 PMC 바로가기 [Article Type] Original Research Reports
Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestineResearch Article Published on 2021-06-142022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] absence Activation administration affected Antiviral Apoptosis coronavirus diarrhea distribution Effect ergosterol peroxide evaluate expression IFN-I immunomodulatory immunomodulatory effect in vitro study in vivo incidence Infection inhibited intestinal Intestinal barrier IκBα mechanisms modulation NF-κB p65 Porcine deltacoronavirus Prevent pro-inflammatory cytokine PROTECT protein expression reduced Replication signaling pathway small intestine tissues treat Treatment upregulating Viral load were infected [DOI] 10.1186/s13567-021-00955-5 PMC 바로가기 [Article Type] Research Article
TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditionsResearch Paper Published on 2021-05-252022-10-28 Journal: Theranostics [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome alveolar alveolar macrophage approach bovine caused condition conditions contagious coronavirus coronavirus disease Coronavirus-2 Critical cytokine cytokine release Cytokines domain drug target Effect ENhance entry of SARS-CoV-2 enzyme-linked immunosorbent assay evaluate examined febrile Fever Gene Expression genes encoding glutathione human cell humans immunofluorescence infect Inflammatory response Interaction knockdown Macrophage macrophages mouse macrophages NF-κB oligonucleotide p65 performed Plasmid primary bovine alveolar macrophage Prolonged fever promote Protein RBD receptor Regulatory resource RNA S-RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S secretion signaling pathway significantly SKF-96365 spike protein receptor-binding domain staining temperature the SARS-CoV-2 THP-1 transfected with TRPV2 was measured were used [DOI] 10.7150/thno.58781 PMC 바로가기 [Article Type] Research Paper
Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by DexamethasoneOriginal Article Published on 2021-04-162022-10-30 Journal: Inflammation [Category] COVID-19, MERS, SARS, [키워드] Activation anti-inflammatory activity blocked caused clinical benefit COVID-19 Cytokine storm Cytokines Degradation Dexamethasone DNA binding Effect experiment Human IL-1β IL-6 IL-8 increase in induction Inflammation Inflammatory inhibition investigated involved IκBα MAPK mechanism molecular mononuclear cell NF-KB NF-κB NF-κB activation NLRP3 inflammasome p65 PBMC PBMCs peripheral Peripheral blood pharmacological target Phosphorylation pro-inflammatory cytokine produced Production recombinant reducing reduction reduction in SARS-CoV-2 SARS-CoV-2 cytokine storm SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein S1 SARS-CoV-2 virus infection significantly increased spike spike glycoprotein stimulated Stimulation TNFα was reduced [DOI] 10.1007/s10753-021-01464-5 PMC 바로가기 [Article Type] Original Article
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteinsArticle Published on 2021-03-152022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, Fulltext, SARS, [키워드] 3CL accessory protein ORF3a accessory proteins blocked complementary complex COVID-19 pandemic deaths disrupt downstream effective functional Host humans immune evasion in vivo indicate Infection Infectious diseases inhibit inhibited inhibitor innate immune innate immune response innate immune responses mice Microbiology Modification nuclear ORF3a p65 pathogenic coronavirus Pathways protease Protein provide replicate Replication responsible RNA SARS-CoV-2 SARS-CoV-2 protein Signaling Spread structural proteins suppressor survival therapeutic agent triggered unique Viral protein viruses [DOI] 10.1038/s41392-021-00515-5 PMC 바로가기 [Article Type] Article
D -Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary FibrosisMedicine Published on 2021-03-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] analyzed Angiogenesis binding collagen coronavirus disease Coronavirus disease 2019 coronavirus disease related pulmonary fibrosis COVID COVID-19 D-limonene database differentially expressed gene docked downloaded expression GeneCard Inflammatory response Lung fibrosis mechanism metabolism monoterpene NF-κB p65 pathway pharmacological Phosphorylation PI3K PI3K/Akt signaling pathway Potential Prevalence PROTECT Protein pulmonary pulmonary fibrosis reported Severe acute respiratory syndrome signaling pathway target targets therapeutic Treatment [DOI] 10.3389/fmed.2021.591830 PMC 바로가기 [Article Type] Medicine