Honghua extract mediated potent inhibition of COVID-19 host cell pathways홍화 추출물 매개 코로나19 숙주 세포 경로의 강력한 억제Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] 치료기술, 치료법, 치료제, [키워드] alkaline phosphatase Analysis Antiviral effect applied Chinese Compound COVID-19 crocin enzyme exhibited Extract high affinity host cell human ACE2 receptor Inflammation investigated kinases mechanism Medicine network pharmacology pathway Pathway analysis phosphatase potential mechanism potential mechanisms Signaling signaling pathway Simulation Traditional Traditional Chinese medicine virus [DOI] 10.1038/s41598-022-15338-9 PMC 바로가기 [Article Type] Article
Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals단핵구 골수 유래 억제 세포는 회복된 SARS CoV2에 감염된 개인의 T 세포 반응을 억제합니다Article Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] adaptive immune responses Antigen arginase caused CD11b CD14 CD33 CD57 Cell characterized clinical recovery coronavirus disease Coronavirus disease 2019 correlated COVID-19 CX3CR1 CXCL1 CXCL2 cytokine production Cytokine storm Cytokines depleting dominant downregulated DQA1 DQB1 effector memory expansion Frequency function functional functions Gene Expression HLA-B HLA-DQA1 HLA-DQB1 HLA-DR Hyperinflammatory Hyperinflammatory response IL-6 IL1β immune immune activation immune responses individual individuals infected individual Infection membrane monocytic-myeloid derived suppressor cells mononuclear cell NLRP3 nucleocapsid pathway Pathway analysis Pathways PBMC PD1 peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells plasma quantity recall recovered regulate remained response RNA-Seq ROS SARS Coronavirus SARS coronavirus 2 SARS CoV2 infection shown spike glycoprotein subset suppress suppresse suppressed suppressor T cell T cell response T cell responses T-cell T-cell responses target TGFβ transcriptional transcriptomic transcriptomic (RNA-Seq). Vaccine viral infection virus [DOI] 10.3389/fimmu.2022.894543 PMC 바로가기 [Article Type] Article
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causesResearch article Published on 2022-06-242022-10-05 Journal: Heliyon [Category] 바이오마커, 치료기술, [키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed [DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article
Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations폐 내피 세포의 단일 세포 전사체 프로파일링은 동적 염증 및 재생 하위 집단을 식별합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Activation Bacterial infections baseline Cell Clustering defined demonstrated division endothelial endothelial cells Endothelium expression Gene Expression H1N1 H1N1 influenza H1N1 influenza virus heterogeneity identify immune response gene immune response genes increased expression infected with SARS-CoV-2 Infectious disease Inflammatory inflammatory lung injury inflammatory signaling Influenza Injury labor limit LPS lung lung endothelial Lung injury MHC gene MHC genes murine organ overexpression Pathway analysis performed phenotypic prevented proliferative promote Pulmonology Pulmonology. regeneration regenerative respond Seurat single-cell single-cell RNA-seq Sox17 subpopulation targeted therapy transcriptomic Vascular vascular bed vascular endothelial cell vascular endothelial cells virus [DOI] 10.1172/jci.insight.158079 PMC 바로가기 [Article Type] Article
Identification of novel regulatory pathways across normal human bronchial epithelial cell lines (NHBEs) and peripheral blood mononuclear cell lines (PBMCs) in COVID-19 patients using transcriptome analysisResearch article Published on 2022-06-022022-10-05 Journal: Informatics in Medicine Unlocked [Category] 변종, 신약개발, [키워드] affected Analysis analysis approaches association cell line cell lines changes in conducted contribute Coronaviruses COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Differential gene expression Drug repurposing enrichment analysis epithelial epithelial cell line exacerbated Factor Gene regulatory networks help identification identify immune system Interaction interactions Lungs mononuclear cell Mutation neurodegenerative disorders NHBE organ pathway Pathway analysis PBMC PBMCs Peripheral blood regulatory network regulatory pathway SARS-CoV-2 significant pathway Streamline Support targets the disease the SARS-CoV-2 therapeutic approach Transcriptome viral replication viral strain virus [DOI] 10.1016/j.imu.2022.100979 [Article Type] Research article
A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers Research Published on 2022-05-042022-10-05 Journal: Translational Psychiatry [Category] 바이오마커, [키워드] Analysis approach association AUC Biomarker Bipolar disorder Clinical practice Cohort Combination Control criteria Depression depressive Depressive symptoms Diagnosis differential diagnosis disorder disorders Genes healthy volunteer help identify implementation management Modification Participants Pathway analysis Patient patients reduce RNA selected sensitivity specificity subtype tested Treatment unipolar depression validation cohort variant [DOI] 10.1038/s41398-022-01938-6 [Article Type] Research
Multi-omic analysis reveals enriched pathways associated with COVID-19 and COVID-19 severity다중 오믹 분석은 COVID-19 및 COVID-19 심각성과 관련된 풍부한 경로를 보여줍니다Article Published on 2022-04-252022-09-11 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] addition analyses Analysis analyzed approach biological pathway biological pathways Cell cell cycle characterized cholesterol clinical outcomes correlation correlations COVID-19 COVID-19 severity death disease disease severity disease status enriched pathway enrichment analysis hospital identify implicated Inflammatory response metabolic processes metabolomics molecular molecules Multiple observé Pathway analysis Patient predict principal components analysis proteomics reflected regression models reveal RNA sequencing data severity stability Symptoms the disease Vitamin was done with COVID-19 [DOI] 10.1371/journal.pone.0267047 PMC 바로가기 [Article Type] Article
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
Bioinformatics and System Biology Approach to Identify the Influences of COVID-19 on Rheumatoid Arthritis류마티스 관절염에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근Article Published on 2022-04-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach Arthritis association bioinformatics Biology candidate drug condition coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset datasets DEGs differentially expressed differentially expressed gene Differentially expressed genes drug drug molecule functional functional enrichment generate hub genes identify Infection influence interactions mechanism molecular mechanism molecular mechanisms Mortality ontological Pathway analysis performed potential molecular PPI PPI network progression protein-protein interaction proteinprotein interaction rapid increase Rheumatoid rheumatoid arthritis rheumatoid arthritis. SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease statistical System Systems biology targeted therapy Transcription transcription factor Treatment were used [DOI] 10.3389/fimmu.2022.860676 PMC 바로가기 [Article Type] Article
The atlas of ACE2 expression in fetal and adult human hearts reveals the potential mechanism of heart-injured patients infected with SARS-CoV-2태아 및 성인 인간 심장에서 ACE2 발현의 아틀라스는 SARS-CoV-2에 감염된 심장 부상 환자의 잠재적 메커니즘을 보여줍니다Article Published on 2022-04-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis analyzed angiotensin angiotensin I angiotensin I converting enzyme 2 binding calcium Calcium signaling Cardiomyopathy coronavirus dilated cardiomyopathy embryonic embryonic development embryos enzyme expressed gene expressing expression expression level expression profile fetal heart heart failure Heart failure. hearts host cell host cells increase infect infected with SARS-CoV-2 molecular docking Myocyte Numerous organs pathway Pathway analysis Patient potential mechanism Protein protein-protein interaction RAS RAS system regulate Renin renin-angiotensin system reveal risk of infection SARS-CoV-2 Sequencing analysis severe acute respiratory syndrome Coronavirus shown single-cell Spike protein Stage transcription profile upregulated upregulation variant spike various tissue various tissues ventricular was increased was used Wnt signaling pathway [DOI] 10.1152/ajpcell.00169.2021 PMC 바로가기 [Article Type] Article