Herpes zoster in patients with lung cancer treated with PD-1/PD-L1 antibodies폐암 환자에서 PD-1/PD-L1 항체로 치료받는 대상포진Article Published on 2022-10-012023-06-01 Journal: Immunotherapy [Category] 대상포진, 두창, 수두, 홍역, [키워드] EGFR tyrosine kinase inhibitor herpes zoster lung cancer PD-1 PD-L1 [DOI] 10.2217/imt-2021-0318
Role of the PD-1 and PD-L1 axis in COVID-19COVID-19에서 PD-1 및 PD-L1 축의 역할Editorial Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] 바이오마커, [키워드] Abstract adaptive adaptive immune cells COVID-19 COVID-19 patient dysregulated expression immune immune cells immune checkpoint molecules Innate immune cells innate immune cells. Ligand PD-1 PD-L1 Prognostic marker Prognostic markers role SARS-CoV-2 Severe case severe cases therapeutic target therapeutic targets [DOI] 10.2217/fmb-2022-0103 PMC 바로가기 [Article Type] Editorial
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness케모카인, 가용성 PD-L1 및 면역 세포 저반응은 SARS-CoV-2 중병의 뚜렷한 특징입니다Article Published on 2022-07-012022-09-12 Journal: American journal of physiology. Lung cellular and [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ARDS C-reactive protein CCL17 CCL26 cellular checkpoint pathway chemoattractant comparison coronavirus disease Coronavirus-2 COVID-19 Critical Critically ill patient CRP CXCL10 demographics enrolled feature hyporesponsiveness identify IFN-γ IL-10 IL-17A IL-6 IL-8 immune Immune cell immune signature in vitro Interaction less lymphocyte Migration molecular monocyte mortality rate multisite not significantly different p value Patient patients patients without COVID-19 PD-L1 plasma Pneumonia profile prospective cohort Regulatory SARS-CoV-2 SARS-CoV-2-positive patient SARS-CoV-2-positive patients Sepsis severe respiratory failure severity subject subjects T cell T-cell TNF-α two groups ventilator-free day with COVID-19 [DOI] 10.1152/ajplung.00049.2022 PMC 바로가기 [Article Type] Article
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causesResearch article Published on 2022-06-242022-10-05 Journal: Heliyon [Category] 바이오마커, 치료기술, [키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed [DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article
Programmed Cell Death-1/Programmed Cell Death-1 Ligand as Prognostic Markers of Coronavirus Disease 2019 Severity코로나바이러스 질병 2019 심각도의 예후 마커로서의 프로그램된 세포 사멸-1/프로그램된 세포 사멸-1 리간드Article Published on 2022-06-202022-09-11 Journal: Cells [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed association B cells B lymphocyte baseline Biomarker CD19 Cell Control controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 severity current disease disease mortality disease severity dysregulation evaluated expression groups hospitalized patient hospitalized patients immune immune dysregulation immunophenotype In-hospital increase Increased Infection intensive care Laboratory Ligand lymphocyte Lymphocytes marker mechanical ventilation moderate moderate to severe Mortality notable oxygen oxygen support parameter patients with COVID-19 patients with moderate patients without COVID-19 PD-1 PD-L1 profile programmed cell death programmed cell death protein programmed cell death protein 1 Protein Research respiratory severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity survival T cell T cells Treatment were used [DOI] 10.3390/cells11121978 PMC 바로가기 [Article Type] Article
Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별Article Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absolute neutrophil count Analysis Aritficial Intelligence biochemical biochemical markers Biochemical parameters Blood urea nitrogen C-reactive protein clinical Cohort control subject control subjects coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical curated cytokine Cytokines dataset differential expression disease severities Efficacy exploratory ferritin granzyme B highlight identify identifying IFN-γ IL-1 IL-10 IL-15 IL-1ra IL-6 immunological Increased Initially interferon Interferon-gamma interleukin investigated Lactate lactate dehydrogenase Liver injury machine machine learning methodology modeling multiplex Multiplex assay Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Necrosis neutrophil nitrogen outcome pandemic pathophysiology pathway Patient PD-L1 potential therapeutic targets predict Predictive predictive models Predictive value predictor radiological receptor RNA RNA seq ROC ROC analysis serum severe cases severity the disease transcriptomics tumor necrosis urea validation cohort variant [DOI] 10.3389/fimmu.2022.865845 PMC 바로가기 [Article Type] Article
Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 InfectionArticle Published on 2022-04-152023-07-08 Journal: Viruses [Category] COVID19(2023년), [키워드] CD62 convalescent COVID-19 Intermediate monocyte monocyte non-classical monocyte. PD-L1 TIM-3 [DOI] 10.3390/v14040819 PMC 바로가기
Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22대형 인간 면역글로불린 중쇄 가변(VH) 도메인 라이브러리의 구축, PD-L1 및 CD22를 표적으로 하는 신규 인간 항체 VH 도메인의 분리 및 특성화Article Published on 2022-04-062022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] antibody antibody domain drug conjugations (DDC) antibody VH domains antigens approved CD22 CDR2 CDR3 chain characterization construction DDC domain Env example FLT3 grafting healthy donor HIV-1 Human in vitro information library library construction. mAb monoclonal antibody novel PD-L1 phage primer Protein provide RBD reagents targeting targets the SARS-CoV-2 therapy variable was obtained was used [DOI] 10.3389/fimmu.2022.869825 PMC 바로가기 [Article Type] Article
Herpes zoster in patients with solid tumors treated with immune checkpoint inhibitors고형 종양 환자에서 면역 체크포인트 억제제로 치료한 대상포진Article Published on 2022-04-012023-05-31 Journal: Immunotherapy [Category] 대상포진, 두창, 수두, 홍역, [키워드] Cancer herpes zoster HZ Immune checkpoint inhibitors Immunotherapy PD-L1 prevention RZV vaccine T-cell Response viral reactivation [DOI] 10.2217/imt-2021-0333
Herpes zoster in patients with solid tumors treated with immune checkpoint inhibitorsArticle Published on 2022-04-012023-05-31 Journal: Immunotherapy [Category] 두창, 수두, 홍역, [키워드] Cancer herpes zoster HZ Immune checkpoint inhibitors Immunotherapy PD-L1 prevention RZV vaccine T-cell Response viral reactivation [DOI] 10.2217/imt-2021-0333