Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis펩티도글리칸 합성을 지원하는 포스포글루코사민 뮤타제로서의 바실러스 서브틸리스 PgcA 월광Research Article Published on 2019-10-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] amino sugar B . subtilis Bacillus subtilis Bacterial binding biosynthesis pathway cell wall cell wall synthesis contribute convert dual enzyme Enzymes Evidence function functional Gain gain-of-function glucosamine Glucose glucose 1-phosphate glucose 6-phosphate increase interact isomerization member mutant Mutation overproduction pathway peptidoglycan PG synthesis phosphate phosphoglucomutase positive precursor subset substrate substrates sugar sugar moiety sugars Support suppresse suppressed synthesis teichoic acid transfer [DOI] 10.1371/journal.pgen.1008434 PMC 바로가기 [Article Type] Research Article
SweC and SweD are essential co-factors of the FtsEX-CwlO cell wall hydrolase complex in Bacillus subtilisSweC와 SweD는 Bacillus subtilis에서 FtsEX-CwlO 세포벽 가수분해효소 복합체의 필수 보조인자입니다.Research Article Published on 2019-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABC Amino acid amino acid substitution amino acid substitutions ATPase Author autolytic enzymes Bacillus subtilis Bacteria bacterial cell bacterial species Cell cell division cell wall characterized cleavage complex composed conserved Control control cell cytokinesis division divisome domain enzyme Factor firmicutes function gram gram-positive bacterium growth homologs hydrolase Hydrolases involved mechanism membrane osmotic lysis peptide peptides peptidoglycan performed Prevent PROTECT Protective Protein regulate regulated Regulatory remodeling required residue residues sacculus subset Support synthesis the cell [DOI] 10.1371/journal.pgen.1008296 PMC 바로가기 [Article Type] Research Article
Essential gene deletions producing gigantic bacteria거대 박테리아를 생성하는 필수 유전자 결실Research Article Published on 2019-06-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated Acinetobacter Analysis antibiotic Antibiotics Bacteria Bacterial Bacterial infections blocked Cell cell wall cell wall synthesis cells cleave consequence conserved creating dead dead cell dead cells deleted Deletion eliminating enzyme Essential feature function functions Genetic Giant giant cell giant cells help hydrolysis identify inactivated independent life lysed lytic transglycosylase mutant mutants Mutation natural transformation osmotic overcome overlapping pathogenic pathway peptide peptidoglycan polymerization precursor predicted produced producing required respond responsible resulting sacculus targets the cell the dead Tn-seq transposon Treatment [DOI] 10.1371/journal.pgen.1008195 PMC 바로가기 [Article Type] Research Article
Laser micro-structured Si scaffold-implantable vaccines against Salmonella Typhimurium레이저 마이크로 구조화된 실리콘 스캐폴드 이식 백신, 살모넬라 타이피무리움에 대한Article Published on 2019-04-102024-08-21 Journal: Vaccine [Category] 살모넬라증, [키워드] immune response Laser manufacturing peptidoglycan Salmonella Typhimurium Scaffold implantation Silicon scaffold. [DOI] 10.1016/j.vaccine.2019.02.080
A switch in surface polymer biogenesis triggers growth-phase-dependent and antibiotic-induced bacteriolysis표면 폴리머 생합성의 전환은 성장 단계 의존적 및 항생제 유도 세균 용해를 촉발한다.Article Published on 2019-04-092024-07-31 Journal: eLife [Category] 폐렴구균 감염증, [키워드] Antibiotics cell wall Other peptidoglycan S. pneumoniae teichoic acid [DOI] 10.7554/eLife.44912 PMC 바로가기
Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium메티오닌 생합성과 수송은 살모넬라 타이피무리움의 성장과 병원성에 기능적으로 중복된다.Article Published on 2018-06-152024-07-29 Journal: Brain stimulation [Category] 살모넬라증, [키워드] Biosynthesis in vivo infection methionine peptidoglycan S-adenosylmethionine (SAM) Salmonella enterica transporter virulence [DOI] 10.1074/jbc.RA118.002592 PMC 바로가기
Phosphorylation-dependent activation of the cell wall synthase PBP2a in Streptococcus pneumoniae by MacPMacP에 의한 폐렴구균에서 세포벽 합성효소 PBP2a의 인산화 의존적 활성화Article Published on 2018-03-132024-08-24 Journal: Microbial Cell Factories [Category] 폐렴구균 감염증, [키워드] Bacterial physiology cell division cell wall PBP peptidoglycan
A Specialized Peptidoglycan Synthase Promotes Salmonella Cell Division inside Host Cells전문화된 펩타이드글리칸 합성효소가 숙주 세포 내에서 살모넬라 세포 분열을 촉진한다.Research Article Published on 2017-12-192024-07-29 Journal: mBio [Category] 살모넬라증, [키워드] cell division intracellular pathogens penicillin-binding proteins peptidoglycan Salmonella [DOI] 10.1128/mBio.01685-17 PMC 바로가기 [Article Type] Research Article
Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarateα-케토글루타레이트의 항상성 조절을 통한 Caulobacter crescentus의 트리카르복실산 회로와 펩티도글리칸 합성 간의 누화Research Article Published on 2017-08-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation addition Alter Antibiotics approach approaches Bacteria bacterial cell bacterial cells biosynthetic block blocks building by-product Caulobacter crescentus caused Cell cell wall cell wall synthesis cellular cellular metabolism cellular processe cellular processes central metabolism characterized classical conserved CRISPRi Crosstalk deletion mutant Disruption drug design energy generate genetics growth highlight homeostasis homeostatic inhibit interfere Interference master regulator metabolism metabolite metabolomics Morphological morphology mutant peptidoglycan phenotype precursors property Replication required resulting reveal robust susceptibility susceptible synthesis TCA cycle the cell transcriptomics tricarboxylic acid while [DOI] 10.1371/journal.pgen.1006978 PMC 바로가기 [Article Type] Research Article
Role of the SRRz/Rz1 lambdoid lysis cassette in the pathoadaptive evolution of Shigellaarticle Published on 2017-06-302024-09-01 Journal: International Journal of Medical Microbiology [Category] 세균성이질, [키워드] Bacterial evolution Bacterial-host interaction Pathoadaptive mutation peptidoglycan Shigella [Article Type] article