Immune response of booster doses of BBIBP-CORV vaccines against the variants of concern of SARS-CoV-2SARS-CoV-2의 우려 변종에 대한 BBIBP-CORV 백신의 추가 용량의 면역 반응Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] (alpha Alpha Antibody titer Antibody titers approved BBIBP-CorV Beta booster booster dose booster doses Cohort COVID-19 COVID-19 vaccination COVID-19 vaccinations dose doses Evidence fold immune response inactivated Inactivated vaccine Inactivated Vaccines inactive individual Lineage lineages neutralization test Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers neutralizing effect observational study offered plaque pooled serum primary dose primary doses PRNT recipient recipients reduction reduction in sample pool SARS-CoV-2 SARS-CoV-2 variants serum serum sample serum samples statistically significant Test the SARS-CoV-2 Vaccinations Vaccine vaccine cohort variant variants variants of concern was done Wuhan [DOI] 10.1016/j.jcv.2022.105161 PMC 바로가기 [Article Type] Observational Study
Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer’s disease Research Published on 2022-05-112022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Affect age alteration Alzheimer’s disease animal model baseline Biomarker Brain buffer change characterized comparable comparison detect determine develop dimension disease dysfunction early stage Effect facilitated Factor Fractal Genotype histopathological increase in indicated injected injection Interaction lack linear longitudinal majority mice neurodegenerative outcomes pathological change Pathologies pathology performed plaque quantified reduction returned statistically the disease wild-type [DOI] 10.1038/s41598-022-11582-1 [Article Type] Research
Neuromyelitis optica spectrum disorder post-COVID-19 infection: A rare case report from Northeast India시신경척수염 스펙트럼 장애 코로나19 감염 후: 인도 북동부에서 발생한 드문 사례 보고Case Reports Published on 2022-05-012022-09-12 Journal: Indian journal of ophthalmology [Category] MERS, 진단, [키워드] acute COVID-19 Ascending paralysis Case report Central nervous system coronavirus disease COVID-19 COVID-19 infection demyelinating disorder distress edema female India Infection lower limbs Multiple Neuromyelitis Optica Patient plaque rheumatoid arthritis steroid the patient unique weakness [DOI] 10.4103/ijo.IJO_61_22 PMC 바로가기 [Article Type] Case Reports
Evaluation of Antiviral Effect against SARS-CoV-2 Propagation by Crude Polysaccharides from Seaweed and Abalone Viscera In Vitro해조류 및 전복 내장의 조다당류에 의한 SARS-CoV-2 증식에 대한 시험관내 항바이러스 효과 평가Article Published on 2022-04-272022-09-11 Journal: Marine Drugs [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Abalone abalone viscera addition Antiviral antiviral activity Antiviral effect COVID-19 discus Effect evaluated expression level followed by Haliotis immunofluorescence assay inhibit SARS-CoV-2 inhibited inhibitory effect Interference nucleocapsid Nucleocapsid proteins plaque Plaque titration polysaccharide polysaccharides Propagation Quantitative Replication RNA copies RNA copy RT-PCR analysis Sargassum SARS-CoV-2 SARS-CoV-2 propagation SARS-CoV-2 replication SARS-CoV-2 spikes seaweed seaweed. Treatment Vero E6 VERO E6 cells viral entry viral infection viscera western blot [DOI] 10.3390/md20050296 PMC 바로가기 [Article Type] Article
Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19 Research Published on 2022-04-072022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] Anti-inflammatory anti-inflammatory activity anti-inflammatory properties antiviral drug characterization component computer Concentration conducted COVID-19 curative demonstrated Efficacy evaluate exhibited fibroblast cells IC50 in-silico In-vitro inhibitor invertebrate investigation molecular docking plaque Potential treatment Red reduction SARS-CoV2 Standard Toxicity Virtual screening [DOI] 10.1038/s41598-022-09809-2 [Article Type] Research
Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 VaccineSARS-CoV-2에 대한 이전 감염은 비활성화된 COVID-19 백신의 1회 투여 후 증가된 보호 체액 반응과 관련이 있습니다Article Published on 2022-03-022022-09-11 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 humoral antibodies antibody antibody kinetics antibody levels Antibody Response Antibody responses assays both viruses CoronaVac COVID-19 COVID-19 vaccine detectable dose elicited ELISA evaluate FIVE Gamma had no immunization inactivated Inactivated vaccine increase in Increased indicated individual induce Lineage lineage B.1 naïve individuals Neutralizing activity neutralizing assays plaque Previous studies previous study PRNT Protective antibody protective antibody response protective antibody responses response retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose sera specific antibodies subject vaccinated individual vaccinated individuals vaccination vaccine dose vaccinees variant were measured [DOI] 10.3390/v14030510 PMC 바로가기 [Article Type] Article
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination동종 및 이종 CoronaVac 또는 BNT162b2 백신 접종 후 SARS-CoV-2 Omicron 변이체 BA.1에 대한 중화 항체Article Published on 2022-03-012022-09-11 Journal: Nature Medicine [Category] SARS, 변종, 진단, [키워드] antibody Antibody titer BNT162b2 booster booster dose circulating convalescent CoronaVac country dominant dose Effectiveness elicited geometric mean geometric mean titer GMT Heterologous homologous individual infected individual Infection Live virus Messenger RNA Neutralizing activity of BNT162b2 omicron Omicron variant plaque plaque reduction neutralization PRNT reduced reductions reductions in SARS-CoV-2 SARS-CoV-2 virus serum serum antibody Spread the SARS-CoV-2 threshold to define vaccinated individual vaccinated individuals vaccination Vaccine variant virus wild-type WT virus [DOI] 10.1038/s41591-022-01704-7 PMC 바로가기 [Article Type] Article
Detailed epitope mapping of SARS-CoV-2 nucleoprotein reveals specific immunoresponse in cats and dogs housed with COVID-19 patientsSARS-CoV-2 핵단백질의 상세한 에피토프 매핑은 COVID-19 환자와 함께 수용된 고양이와 개에서 특정 면역 반응을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: Research in veterinary science [Category] MERS, SARS, 진단, 치료법, [키워드] animals Antigen antigenic C-terminus coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID19 develop disease disease control domain Double antigen ELISA ELISA epitope epitope mapping gold gold standard Human immunized Infection initial neutralization test pandemic Patient plaque PRNT Protein raising reported representing respiratory respiratory syndrome coronavirus 2 reveal SARS-CoV-2 SARS-CoV-2 nucleoprotein sera Serological assay specificity susceptible target Transmission Viral Viral antigen was used with COVID-19 [DOI] 10.1016/j.rvsc.2021.12.020 PMC 바로가기 [Article Type] Article
SARS-CoV-2 enzyme-linked immunosorbent assays as proxies for plaque reduction neutralisation testsSARS-COV-2 효소-연결 면역 흡착제 분석 플라크 환원 중화 시험을위한 프록시로서Clinical Trial Published on 2022-03-012022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] antibodies can be used cells coronavirus correlated detect determined by Diagnostic markers diagnostic test diagnostic tests ELISA enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays evaluated generate IgG IgG and IgM IgM immune response immune responses Immunoglobulin immunoglobulins infecting likelihood magnitude MOST NAb NAbs neutralisation test neutralising Neutralising Antibodies neutralising antibody nucleocapsid protein plaque Prevent PRNT Receptor binding domain reduction respiratory Respiratory Coronavirus rising robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike severe acute respiratory coronavirus severe acute respiratory coronavirus 2 Spread subunit titre viral infection virus [DOI] 10.1038/s41598-022-07263-8 PMC 바로가기 [Article Type] Clinical Trial
A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection진정한 SARS-CoV-2 감염을 위한 프로테아제 활성화 발광 바이오센서 및 리포터 세포주Research Article Published on 2022-02-102022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] 384-well plate activate Activation antibody approaches can be used Cell cell line cleavage cleave COVID-19 demonstrated detect enzyme expressing expression faster generate gold gold standard infected cells Infection infection with SARS-CoV-2 Infectious virus Laboratory lack linkers luciferase neutralisation Neutralising Antibodies neutralising antibody number of infected optical plaque plaque assays protease Proteases PROTECT Protein quantitation released Replication reporter reporter cell reporter cells required SARS-CoV-2 SARS-COV-2 infection serological signal technique these viruses time-consuming titration to define utility variants variants of concern variants of SARS-CoV-2 Viral viral infection virus viruses [DOI] 10.1371/journal.ppat.1010265 PMC 바로가기 [Article Type] Research Article