Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary ciliavimentin, ACE2 및 SARS-CoV-2 스파이크 단백질의 세포 표면 검출은 일차 섬모에서 선택적 공동 국소화를 나타냅니다Article Published on 2022-04-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acetylated tubulin Arl13b binding Cell cell surface cell types cells cellular receptor cellular receptors ciliated cytoplasm docking Extracellular facilitate filament protein immunoreactivity Incubation Interaction Intermediate filament marker moderate occur Particle plasma membrane platform positive Protein receptor reported reveal S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective spike Spike protein Spike proteins structures tubulin vimentin viral invasion virus [DOI] 10.1038/s41598-022-11248-y PMC 바로가기 [Article Type] Article
Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection Research Published on 2022-04-192022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] activity addition Breakthrough infection Cell complex COVID-19 DNA topoisomerase downstream entry of SARS-CoV-2 expression profiling facilitate human airway epithelial human lung in viral Infection inhibit inhibit SARS-CoV-2 inhibitor interact Interaction membrane protein modulate offer overcome plasma membrane Post-vaccine promote Protein receptor receptors reduced SARS-CoV-2 strain Support target the SARS-CoV-2 therapeutic target therapy tissues viral entry [DOI] 10.1038/s41598-022-10293-x [Article Type] Research
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis세포내 및 형태학적 분석을 통한 SARS-CoV-2에 대한 플리티뎁신의 항바이러스 활성 규명Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] absence Affect Alpha Analysis antitumor agent Antiviral antiviral activity antiviral drugs Antiviral treatment approach biogenesis block caused Cell Complete coronavirus COVID-19 double-stranded RNA dsRNA Efficacy electron electron microscopy elongation factor eukaryotic translation evaluate the effect Extracellular genome replication group host protein infected Vero E6 cells Interaction labeling mechanism mechanism of action Microscopy morphogenesis Morphological morphological analysis New coronavirus new coronavirus SARS-CoV-2 offer organelle pandemic plasma membrane Plitidepsin Post-infection progeny Protein provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2. shown Structure subcellular Support target TEM transmission electron microscopy treated unique Vero E6 Vero E6 cell VERO E6 cells Vesicle viral infection Viral particles viral replication virion virus virus viruses [DOI] 10.1016/j.antiviral.2022.105270 PMC 바로가기 [Article Type] Article
Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium사람의 기도 상피에서 SARS-CoV-2 진입 및 발아에 대한 미세구조적 통찰력Article Published on 2022-03-252022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] ACE2 airway epithelium B.1.1.7 B.1.1.7 variant budding cilia ciliary ciliated ciliated cell ciliated cells Concentration direct fusion envelope epithelial cells examined excluded explain Extracellular Genome goblet host cells Human airway epithelium Intact isolate isolates mechanism membrane membranes microvilli nucleocapsid nucleocapsids periphery plasma membrane profile profiles S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells TMPRSS2 tomography transmission electron microscopy Viral viral entry viral membrane virion virions virus [DOI] 10.1038/s41467-022-29255-y PMC 바로가기 [Article Type] Article
Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses In VitroResearch Article Published on 2022-01-152022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] ACE ACE2 acute respiratory syndrome alcohols approach Bacteria Caco-2 cell Camostat mesylate Chloroquine coronavirus coronavirus Critical demonstrated develop entry of SARS-CoV-2 Formulation host cell host cells human host cells Increasing Infection inhibit inhibitor Interaction mechanism membranes multitude Naturally novel outbreak pandemic pathogenic virus pathological performed plasma membrane proliferation promoted receptor ACE2 reduce Remdesivir SARS-CoV-2 SARS-CoV-2 replication saturated serine protease TMPRSS2 Spread time-consuming TMPRSS2 Vaccines viral infectivity viral S protein virus virus [DOI] 10.1155/2022/1558860 PMC 바로가기 [Article Type] Research Article
Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses In VitroResearch Article Published on 2022-01-152022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, SARS, [키워드] ACE ACE2 acute respiratory syndrome alcohols approach Bacteria Caco-2 cell Camostat mesylate Chloroquine coronavirus coronavirus Critical demonstrated develop entry of SARS-CoV-2 Formulation host cell host cells human host cells Increasing Infection inhibit inhibitor Interaction mechanism membranes multitude Naturally novel outbreak pandemic pathogenic virus pathological performed plasma membrane proliferation promoted receptor ACE2 reduce Remdesivir SARS-CoV-2 SARS-CoV-2 replication saturated serine protease TMPRSS2 Spread time-consuming TMPRSS2 Vaccines viral infectivity viral S protein virus virus [DOI] 10.1155/2022/1558860 PMC 바로가기 [Article Type] Research Article
SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry423 Published on 2022-01-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome analyses binding C terminal Cell cell entry cell surface pathway complex coronavirus cytosolic demonstrated domain endocytic Endocytic pathway enzyme functional fusing homeostasis host cell inhibiting Interaction Invasion membrane fusion motif physiological conditions plasma membrane Prevent Protein RBD recent regulate Regulation resulting retromer SARS coronaviruses SARS-CoV-2 SARS-COV-2 infection Significance SNX27 suppresse surface receptor therapeutic target type I viral entry virus was used [DOI] 10.1073/pnas.2117576119 PMC 바로가기 [Article Type] 423
Potential Mechanisms Underlying Hypoxia-Induced Diabetes in a Rodent Model: Implications for COVID-19Article Published on 2021-12-142022-10-31 Journal: Children [Category] COVID-19, [키워드] β-cell acute respiratory distress arising Blood chloride chloride ion chloride levels COVID-19 COVID19-induced hypoxia Desaturation Diabetic elevate fasting blood Glucose hyperglycemia hypoxia hypoxic event insulin KCC2 lack oxygen pancreatic β-cells patients with COVID-19 plasma membrane Potential previous study reduce reduced reported rodent secretion shown subsequent Symptom β-cell [DOI] 10.3390/children8121178 PMC 바로가기 [Article Type] Article
Pleural Mesothelial Cells Modulate the Inflammatory/Profibrotic Response During SARS-CoV-2 InfectionMolecular Biosciences Published on 2021-11-262022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 expression ADAM17 analysed Analysis analyzed assays Cell confocal microscopy COVID-19 COVID-19 disease COVID-19 patients cytokeratin cytokine direct infection ELLA epithelial Evidence expressed expression fibrosis highlight immune response implicated in vivo Infection Inflammatory cytokine Inflammatory cytokines interferons Lung fibrosis marker MCs mesothelial cells mesothelial to mesenchymal transition morphology NRP1 Pathogenesis Patient plasma membrane pleura produced promoter pulmonary fibrosis receptor reported response RT-PCR SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 replication shown supernatant sustained TMPRSS2 western blot WT1 [DOI] 10.3389/fmolb.2021.752616 PMC 바로가기 [Article Type] Molecular Biosciences
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article