Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and PharmacodynamicsCOVID 폐렴에서 정맥내 나파모스타트 메실레이트의 무작위 대조 시험: 안전성, 약동학 및 약력학을 조사하기 위한 1b/2a상 실험 연구Clinical Trial Published on 2022-02-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% CI Administered adverse events Analysis Anti-inflammatory Anticoagulant anticoagulant effect anticoagulant effects antiviral activity assigned average characterisation Controlled trial COVID COVID-19 COVID19 creatinine credible interval demonstrated dose Edinburgh Endpoint endpoints Evidence evidence of Hospital stay hospitalised hospitalised patient Hospitalised patients inactive independent Infectious diseases intravenous intravenous infusion manuscript maximum mean difference mesylate metabolites nafamostat Nafamostat mesylate observé Odds ratio open open label Oxford oxygen Patient patients Pharmacodynamics pharmacokinetics phase Phase 2 PK data plasma platform Pneumonitis Primary outcome Primary outcomes progressed randomised randomised controlled trial Randomly rate ratio receive reported Repurposed drug Research respiratory Respiratory medicine response SARS-CoV-2/COVID-19 Seven significantly higher significantly more SOC Standard of care statistically significant difference therapy Tolerability Total Total manuscript word count. Trial university with COVID-19 [DOI] 10.1016/j.ebiom.2022.103856 PMC 바로가기 [Article Type] Clinical Trial
AI Lung Segmentation and Perfusion Analysis of Dual-Energy CT Can Help to Distinguish COVID-19 Infiltrates from Visually Similar Immunotherapy-Related Pneumonitis Findings and Can Optimize Radiological WorkflowsArticle Published on 2021-12-232022-10-29 Journal: Tomography [Category] COVID-19, SARS, [키워드] 105 patient artificial intelligence blinded BMI Can Concentration COVID-19 Diagnosis dual energy faster finding greater ICC Impact Infiltrate Intraclass correlation coefficient investigated linear mixed model Metrics no significant difference patients with COVID-19 Perfusion Pneumonitis pulmonary lobe radiologist Radiologists Ratio scored Segmentation selected significantly significantly higher tomography Validity vessel Volume was determined was measured was used X-ray computed [DOI] 10.3390/tomography8010003 PMC 바로가기 [Article Type] Article
Case Report: Clinical Management of a Patient With Metastatic Non-Small Cell Lung Cancer Newly Receiving Immune Checkpoint Inhibition During Symptomatic COVID-19증례 보고: 코로나19 증상이 있는 동안 면역 체크포인트 억제를 새로 받은 전이성 비소세포폐암 환자의 임상 관리Case Reports Published on 2021-12-202022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] activated ambulatory patient Analysis anti-cancer treatment anti-PD1 antiviral immunity blockade CD4 CD8 cellular change clinical Corticosteroid Course COVID-19 CT scan Effect feasible Follow-up healthy High-dose Hospitalized humoral immune response IgG immune checkpoint Immunotherapy inhibition initiated lesion lung cancer male malignancy management metastatic Neutralizing NSCLC Patient PD1 Pembrolizumab Pneumonia Pneumonitis presenting Radiographic SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection serum sustained symptomatic T cell Tfh the patient treatment initiation worsened [DOI] 10.3389/fimmu.2021.798276 PMC 바로가기 [Article Type] Case Reports
Evaluation of new or repurposed treatments for COVID-19: protocol for the phase Ib/IIa DEFINE trial platformCOVID-19에 대한 신규 또는 용도 변경 치료제 평가: Ib/IIa상 DEFINE 시험 플랫폼 프로토콜Article Published on 2021-12-152022-09-11 Journal: BMJ Open [Category] 임상, [키워드] acceptance adaptive administration Analysis Appropriate approval Arm ARMS assisted ventilation caused changes in clinical trial Coagulation Cohort Community Complete computer COVID-19 COVID-19 therapy dependent on development during treatment effective Efficacy Ethics ethics committee EudraCT Evidence evidence of Experimental medicine exploratory Follow-up hospital Hospital stay hospitalised patient Infection Infectious diseases information initial mechanism mechanism of action Medicine MHRA National Health Service NEWS2 NHS Novel coronavirus Open-label Ordinal Scale oxygen Oxygen requirements participant Pathways Patient patient cohorts patient safety patients with COVID-19 peer-reviewed pharmacokinetic Pneumonia Pneumonitis positive present product protocol randomisation randomised Randomised Evaluation REC recovery recruited recruitment registration number research and development Research Ethics Research Ethics Committee respiratory medicine (see thoracic medicine) Safe SARS-CoV-2 score secondary Standard of care statistical analysis submitted Support Therapeutics therapy Thoracic Treatment treatment arm treatment period Trial trial platform variable Viral load viral-induced WHO ordinal scale [DOI] 10.1136/bmjopen-2021-054442 PMC 바로가기 [Article Type] Article
Evaluating Deep Neural Network Architectures with Transfer Learning for Pneumonitis DiagnosisResearch Article Published on 2021-09-122022-10-31 Journal: Computational and Mathematical Methods in Medicine [Category] Coronavirus, MERS, SARS, [키워드] Activation alleviate Analysis architecture AUROC cause chest X-ray Chest X-ray images dataset deep deep learning Deep Learning Method detection Diagnosis Early detection evaluate Evaluating fine-tune help Infectious disease Inflammation Kaggle knowledge learning life-threatening network Neural outperform Pneumonitis Predictive recall recent significantly transfer was used X-ray [DOI] 10.1155/2021/8036304 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED PatientsSARS-CoV-2 스파이크 단백질 유도 단클론 항체는 APECED 환자의 COVID-19 합병증을 개선할 수 있습니다Clinical Trial Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료법, [키워드] administration Admission AIRE antibody APECED APS-1 autoantibody Autoimmune autoimmune regulator bamlanivimab bamlanivimab-etesevimab candidiasis caused center clinical Clinical effect Complication Course COVID-19 COVID-19 infection COVID-19 pneumonia COVID-19 symptom COVID-19 symptoms death develop drug early treatment Efficacy Emergency use authorization enrolled entry of SARS-CoV-2 etesevimab evaluated food high risk high-risk patient High-risk patients Hospitalization host cells IFNs immune Infection intensive care interferons interferons (IFNs invasive life-threatening loss-of-function mutation loss-of-function mutations mAb mAbs Mild-to-moderate monoclonal antibodies monoclonal antibody Neutralizing NIH nucleocapsid protein Patient patients Pneumonia Pneumonitis prophylactically protocol reduced SARS-CoV-2 SARS-CoV-2 spike protein severe disease spike Spike protein syndrome the SARS-CoV-2 type-1 IFN autoantibodies US Food and Drug Administration ventilatory support without affecting [DOI] 10.3389/fimmu.2021.720205 PMC 바로가기 [Article Type] Clinical Trial
Proning related bilateral anterior ischaemic optic neuropathy in a patient with COVID-19 related acute respiratory distress syndromeCase Report Published on 2021-07-132022-10-28 Journal: BMC ophthalmology [Category] COVID-19, SARS, [키워드] acute respiratory distress ARDS Compression ischaemic optic neuropathy counting finger COVID-19 COVID-19 pandemic Critical care Diagnosis eight Factor hypoxemic indirect ophthalmoscopy intensive care knowledge male mechanical ventilation Mild oedema pallor Patient patient with COVID-19 patients with COVID-19 peripheral vision Pneumonitis positive preserved prone prone positioning proning PROTECT reduced reported risk SARS-CoV- 2 Sedation syndrome the SARS-CoV-2 virus therapeutic strategy treat Treatment Vision loss visual acuity visual impairment [DOI] 10.1186/s12886-021-02028-9 PMC 바로가기 [Article Type] Case Report
Randomised, controlled, open label, multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission, morbidity and mortality in adult patients with COVID-19COVID-19를 가진 성인 환자의 ICU 입원, 이환율 및 사망률을 방지하기위한 고압 산소의 안전성 및 효능을 탐색하기위한 무작위, 제어, 개방형 라벨, 다중 센터 임상 시험Randomized Controlled Trial Published on 2021-07-052022-08-31 Journal: BMJ Open [Category] Fulltext, SARS, 임상, 진단, 치료제, [키워드] Analysis anti-inflammatory drug approved best blood sample Blood samples case report form Clinical data clinical trial collected COVID-19 criteria defined Dexamethasone dissemination effective Efficacy electronic case report form Ethics EudraCT evaluate FIVE HBO hyperbaric oxygen Hypothesis ICU ICU admission ICU admissions immunology Inconclusive independent Infectious diseases inflammatory reaction Inflammatory response institutional review board intensive & critical care intensive care intensive care unit load massive inflammatory mitigate molecular analyses morbidity morbidity and mortality Mortality multicentre open Open Access open label oxygen parameter parameters Patient patients with COVID-19 peer-reviewed Pneumonitis positive Prevent primary endpoint product randomisation randomised recorded reduce repeated reported resources risk factor Safe Safety Monitoring Board severe COVID-19 shown subject Swedish Swedish Medical Product Agency tested thoracic medicine Treatment treatment for COVID-19 Trial Trial registration Trigger ventilatory support [DOI] 10.1136/bmjopen-2020-046738 PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1 + neutrophils and CD14 + monocytesCOVID-19와 RA는 PD-L1 + 호중구 및 CD14 + 단핵구를 구동하는 SPP1 골수성 경로를 공유합니다Research Article Published on 2021-06-182022-09-10 Journal: JCI Insight [Category] MERS, 바이오마커, [키워드] Activation alveoli appear Arthritis Autoimmune diseases BALF Bronchoalveolar lavage fluid cause CD14 CD48 Chronic inflammatory arthritis Cluster Concentration COVID-19 COVID-19 pathogenesis disease driven by FABP4 FCN1 hallmark healthy high plasma levels IHC Infectious disease Inflammation innate response intensive care unit investigation lung Macrophage macrophage cluster macrophage clusters macrophages mechanism mediators monocyte Monocytes myeloid cell neutrophil Neutrophils pathogenic pathology pathway PD-L1 plasma plasma concentrations Pneumonitis predicted Predictive predominant proinflammatory remained rheumatoid arthritis S100A12 severe COVID-19 severe pneumonia SPP1 synovial synovitis tissue trajectory transcriptionally transfer TREM2 unique upstream [DOI] 10.1172/jci.insight.147413 PMC 바로가기 [Article Type] Research Article
GABA A -Receptor Agonists Limit Pneumonitis and Death in Murine Coronavirus-Infected MiceArticle Published on 2021-05-232022-10-28 Journal: Viruses [Category] COVID-19, [키워드] administration agonist Anti-inflammatory effects approach candidate Cell clinically coronavirus Coronavirus infections Coronavirus replication Course COVID-19 death death rate epithelial cell Express GABA GABA-receptors help immune system Infection information limit lung injuries Lungs mice mouse hepatitis virus (MHV) murine hepatitis virus Pneumonitis receptor reduced Safe severity shown significantly Symptoms therapeutic effect therapy treat Treatment viral infection Viral load [DOI] 10.3390/v13060966 PMC 바로가기 [Article Type] Article