Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding DomainChemistry Published on 2020-10-232022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome agent aggregate angiotensin approach bile acids binding binding site caused clinically Consensus coronavirus coronavirus disease COVID-19 derivative domain drug drug repurposing and repositioning Evidence exploratory help identify in silico Approach in vitro inhibit inhibitors Interaction molecular natural Naturally nutraceuticals pocket Protein RBD Receptor binding domain reduce respiratory tract infection SARS CoV-2 SARS-CoV-2 SARS-CoV-2 entry secondary bile acid spike Spike protein the RBD the SARS-CoV-2 the Spike to define Viral proteins Virtual screening β-sheet [DOI] 10.3389/fchem.2020.572885 PMC 바로가기 [Article Type] Chemistry
The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoVCommunication Published on 2020-08-192022-10-28 Journal: Viruses [Category] COVID-19, [키워드] ACE2 Analysis angiotensin-converting enzyme-2 binding binding pockets caused Comparative conformational flexibility CoV COVID-19 disease effective Health Host host cell Human infect Infection infection rate Interaction lack MERS-CoV Middle East N-terminal domain Novel coronavirus NTD pocket receptor Region Respiratory illness SARS-CoV SARS-CoV-2 SARS-CoV-2 spike glycoprotein sequence sequence similarity similarity spike spike glycoprotein syndrome the SARS-CoV-2 the spike protein therapeutic interventions tissue tropism Treatment Vaccine virus virus entry worldwide pandemic [DOI] 10.3390/v12090909 PMC 바로가기 [Article Type] Communication
A Comprehensive Mapping of the Druggable Cavities within the SARS-CoV-2 Therapeutically Relevant Proteins by Combining Pocket and Docking Searches as Implemented in Pockets 2.0Article Published on 2020-07-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis approach binding binding pocket blind docking Cavity Combination Comprehensive coronavirus 2 docking docking simulations in silico mapping performed pocket pocket druggability pocket search Protein reached recognize SARS-CoV-2 SARS-CoV-2 protein targets the SARS-CoV-2 Virtual screening [DOI] 10.3390/ijms21145152 PMC 바로가기 [Article Type] Article
Chest Computed Tomography and Lung Ultrasound Findings in COVID-19 Pneumonia: A Pocket Review for Non-radiologistsMedicine Published on 2020-06-262022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] assist Chest computed tomography COVID-19 Diagnosis disease finding highlight Infectious disease lung Lung ultrasound management manifestation pandemic Pneumonia pocket radiological examination researcher review RT-PCR SARS-CoV-2 sensitivity Spread Ultrasound [DOI] 10.3389/fmed.2020.00375 PMC 바로가기 [Article Type] Medicine
Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study자궁 경부 종양에 대한 유전적 감수성 정의 - 전체 게놈 연관 연구Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele amino-acid Antigen approaches association biological basis Cancer cancer development carried cervical cancer Combination complex correlation demonstrated determine determined by DRB1 error foundation Future Genetic genetic loci genetic risk genetic risk score genetic risk scores genetic susceptibility Genetic variant genetic variants Genome-wide association study healthy controls highest HLA HLA alleles HLA haplotype HLA-B HLA-DRB1 host genetics HPV human leukocyte antigen human papillomavirus identify immune immune-related protein immune-related proteins include increased risk indicated Infection inheritance involved leukocyte major histocompatibility complex MHC MHC alleles neoplasia performed pocket Previous studies previous study Prognosis progression Protective residue risk risk factor Risk factors screening methods standard error statistical the major histocompatibility to define Treatment variant women [DOI] 10.1371/journal.pgen.1006866 PMC 바로가기 [Article Type] Research Article