Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19Article Published on 2021-09-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome ADAM17 analyzed androgen androgens angiotensin converting enzyme 2 cardiac cardiometabolic cathepsin L caused complications conditions coronavirus coronavirus disease COVID-19 Deleterious Dihydrotestosterone disorder Endocrine exacerbated expression fat Fat mass female furin high risk increase in kidney LFD mice mitigate Modification modulated mRNA expression obesity outcome Ovary Polycystic polycystic ovary Polycystic ovary syndrome positively correlated Protein protein expression receptor renal SARS-CoV-2 SARS-CoV-2 viral serum severity susceptibility syndrome TMPRSS2 TMPRSS4 treated Treatment upregulated weight loss women [DOI] 10.3390/ijms22189746 PMC 바로가기 [Article Type] Article
Sleep Disruption and Depression, Stress and Anxiety Levels in Women With Polycystic Ovary Syndrome (PCOS) During the Lockdown Measures for COVID-19 in the UKGlobal Women's Health Published on 2021-06-042022-10-31 Journal: Frontiers in Global Women's Health [Category] COVID-19, [키워드] adverse impact age Anxiety body mass index Cohort Comorbidity COVID-19 COVID-19 pandemic cross-sectional DASS-21 Depression Diagnosis dichotomized Disruption domain domains exhibited greater group Health Insomnia Insomnia Severity Index inverse correlation ISI Level lockdown majority measure media mental health number of comorbidities Ovary participant Polycystic Polycystic ovary syndrome positively correlated problem Quality of life questionnaire recruited reported required Research response Sleep statistically Stress stress level Stress Scale syndrome women [DOI] 10.3389/fgwh.2021.649104 PMC 바로가기 [Article Type] Global Women's Health
SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19안드로겐과다증 암컷 마우스의 SARS-CoV-2 바이러스 진입 단백질: PCOS 및 COVID-19가 있는 여성에게 미치는 영향Article Published on 2021-04-252022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 mRNA ACE2 protein ADAM ADAM17 Affect androgen Androgen receptor androgens angiotensin angiotensin I angiotensin I converting enzyme 2 Body body composition body weight Brain cardiometabolic cathepsin cathepsin L causative agent cecum characterized Comorbidities COVID-19 COVID-19 pathology determined by Dihydrotestosterone disorder downregulated dysfunction elevated ELISA Endocrine enzyme fasting fasting glucose fat furin Glucose heart highlight host cell host cells host proteases hyperandrogenism infect kidney lean mass lung male mass mice morphology Mortality mRNA multiple tissue multiple tissues obesity organ systems ovarian Ovary ovulatory pathology Patient Polycystic polycystic ovary Polycystic ovary syndrome priming protease proteases Tmprss2 Protein protein level protein levels qPCR quantified receptor regulate renal risk risk factor Risk factors RT-qPCR SARS-CoV-2 SARS-CoV-2 entry serum severe COVID-19 severity small intestine tissues TMPRSS2 TMPRSS4 treated Treatment upregulated Urine was determined was measured Western-blot with COVID-19 women [DOI] 10.3390/ijms22094472 PMC 바로가기 [Article Type] Article
Biomarkers of COVID-19 severity may not serve patients with polycystic ovary syndromeCOVID-19 중증도의 바이오마커는 다낭성 난소 증후군 환자에게 제공되지 않을 수 있습니다Comment Published on 2021-02-112022-09-10 Journal: Journal of Translational Medicine [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] Biomarkers Coagulation factors COVID-19 COVID-19 severity Patient Platelet degranulation Polycystic ovary syndrome SARS-CoV-2 syndrome [DOI] 10.1186/s12967-021-02723-7 PMC 바로가기 [Article Type] Comment
Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?Original Research Paper Published on 2020-08-182022-10-31 Journal: Metabolism Open [Category] COVID-19, [키워드] ACE2 ACE2 protein age angiotensin-converting enzyme 2 angiotensinogen aptamer blood pressure blood vessels BMI Cell Cohort condition COVID-19 infection CRP described diabete diastolic elevated high risk hypertension independent inherent insulin resistance intestines kidneys Lungs obesity plasma Plasma level plasma protein Polycystic ovary syndrome Protein RAS receptor Renin Result risk SARS-CoV-2 SARS-CoV-2 coronavirus Severe COVID-19 Infection severe disease slow syndrome System T2D target cell Type type 2 diabete Waist circumference women [DOI] 10.1016/j.metop.2020.100052 PMC 바로가기 [Article Type] Original Research Paper
Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemicOpinion Published on 2020-07-152022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] Affect affected age age and sex androgens association Care Clinical practice complex conditions COVID-19 COVID-19 outbreak COVID-19 pandemic diabetes disorder Endocrine Factor female healthcare services Healthcare system higher risk hyper-inflammation hypertension lower risk maintain management manifestation obesity outcomes overlap pandemic Patient patient population PCOS polycystic ovary Polycystic ovary syndrome potential risk predisposition Prevalence receive recommendation reproductive risk risk factor SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 severe COVID-19 significantly Standard of care syndrome type 2 diabetes Vitamin D vitamin D levels women [DOI] 10.1186/s12916-020-01697-5 PMC 바로가기 [Article Type] Opinion
A Polygenic and Phenotypic Risk Prediction for Polycystic Ovary Syndrome Evaluated by Phenome-Wide Association StudiesClinical Research Article Published on 2020-06-092024-09-04 Journal: The Journal of Clinical Endocrinology & Metabolism [Category] 대상포진, [키워드] genomic prediction Phenome-wide association study Polycystic ovary syndrome polygenic risk score [DOI] 10.1210/clinem/dgz326 PMC 바로가기 [Article Type] Clinical Research Article