Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Intensive care medicine [Category] Fulltext, MERS, 바이오마커, [키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19 [DOI] 10.1007/s00134-022-06869-w PMC 바로가기
A global epidemiological analysis of COVID-19 vaccine types and clinical outcomesArticle Published on 2022-11-012022-11-16 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, [키워드] adenovirus vaccine Adenovirus-vectored vaccine adjust age aggregate Analysis analysis analyzed Clinical outcome Comparative comparative effectiveness confounding factors correlation country Coverage COVID-19 COVID-19 vaccine death distribution dominant Effectiveness eligible epidemiological evaluate inactivated Inactivated virus vaccine longitudinal analysis Messenger RNA mixed-effects modeling mRNA mRNA vaccine mRNA vaccine. Nonpharmaceutical interventions P-value performed Population public health repeated measure SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly higher significantly lower vaccination Vaccine Virological virus [DOI] 10.1016/j.ijid.2022.09.014 PMC 바로가기
A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in catsSARS-CoV-2의 스파이크 단백질을 기반으로 하는 서브유닛 백신 후보는 고양이의 감염성 바이러스 발산을 방지합니다Article Published on 2022-11-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected cats demonstrated described effective human infection Infection Infectious virus Neutralizing antibody response occurred Oropharyngeal Population Prevent preventive measure preventive measures produced Protein rectal swab SARS-CoV-2 SARS-CoV-2 virus spike Spike protein submitted subunit Subunit vaccine Subunit vaccine. susceptible the disease the SARS-CoV-2 virus the Spike Transmission Trial triggered vaccination Vaccine vaccine candidate Viral viral infection virus [DOI] 10.1016/j.rvsc.2022.05.003 PMC 바로가기 [Article Type] Article
Incidence and outcome of SARS-CoV-2 infection in a pediatric kidney transplant recipient cohort from a single center in Northern ItalyArticle Published on 2022-11-012022-11-16 Journal: Pediatric transplantation [Category] COVID19(2023년), SARS, 치료기술, [키워드] adolescents children clinically Cohort concern contrary COVID-19 criteria detect duration of symptom Effect eight enrolled epidemiological high risk hospital Immunocompromised patients incidence IQR Italy kidney kidney transplant mortality rate Nasopharyngeal swab observation period outcome Patient pediatric pediatric kidney transplant pediatric transplantation performed Population positive patients positive RT-PCR recipient recipients renal required risk RT-PCR RT-PCR test RT-PCR testing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 single center solid organ transplant solid organ transplant. solid organ transplantation SOT specific treatment Swab symptomatic Test tested the healthy therapy [DOI] 10.1111/petr.14335 PMC 바로가기
Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replicationArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] added antibiotic antimalarial Antiviral approved binding domain Bruton tyrosine kinase inhibitors China claimed contagious Control country COVID-19 pandemic Dependent disease domain drug drug design FDA in viral in-depth analysis increase Infection inhibiting inhibitor Interaction interfere M pro MD simulation number of infected outbreak Papain Population protease provide Psychological distress quinoline based FDA approved Drugs. RBD Remdesivir Replication required resource RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 selected Spike protein spread to target Vaccines viral entry viral replication Virtual screening [DOI] 10.1080/07391102.2021.1913228 PMC 바로가기
Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish populationArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 variant allele frequency Analysis analyzed calculated coding coding variant Cohort conducted contribute COVID-19 database defined filtered Frequency functional Genetic Genome host cell increase infected patient Intronic lack majority National nonsynonymous variant Population populations Protective retrospective risk factor SARS-CoV-2 SARS-COV-2 infection susceptibility Symptom These data TMPRSS2 variant Variant. variants Variation whole-exome sequencing with COVID-19 [DOI] 10.1002/jmv.27976 PMC 바로가기
A Statistical Non-Parametric data analysis for COVID-19 incidence dataArticle Published on 2022-11-012023-07-09 Journal: ISA transactions [Category] COVID19(2023년), [키워드] COVID-19 Generalized additive model India Population rural population Temperature. [DOI] 10.1016/j.isatra.2022.05.027 PMC 바로가기
Antibody and T-cell responses by ultra-deep T-cell receptor immunosequencing after COVID-19 vaccination in patients with plasma cell dyscrasiasArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] 진단, [키워드] age anti-CD38 antibodies antibody Antibody Response Antibody testing antibody titres Antigen binding domain BNT162b2 breadth Cell comparable coronavirus disease correlated COVID-19 COVID-19 vaccination demonstrated detectable dose dyscrasia elicit Genome healthy humoral immune immunization Immunocompromised Immunoglobulin Increasing initial Intervention investigated JNJ-78436735 maturation median mRNA vaccine mRNA-1273 Myeloma of BNT162b2 Patient patient population plasma Population proportion receiving Region response spike-specific T-cell Spike-specific T-cell responses Surface glycoprotein T-cell T-cell receptor T-cell Response TCR tested therapy underlying disease vaccination Vaccines Vaccines. [DOI] 10.1111/bjh.18434 PMC 바로가기
An external quality assessment for the molecular testing of the SARS-CoV-2 virus genome in Zhejiang Province, ChinaArticle Published on 2022-11-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy Asymptomatic CDC China Combination Concentration concentrations Concordance COVID-19 COVID-19 pandemic Culture diagnostics external quality assessment false-negative False-positive Genome infected individual Laboratory medium molecular molecular diagnostics. negative sample nucleic acid extraction organized participated PCR Population positive sample provide public health rapid expansion reagents SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 tests serial dilution the SARS-CoV-2 virus viral titer Zhejiang [DOI] 10.1016/j.diagmicrobio.2022.115766 PMC 바로가기
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기