Population Pharmacokinetics of Antimalarial Naphthoquine in Combination with Artemisinin in Tanzanian Children and Adults: Dose Optimization탄자니아 아동 및 성인에서 아르테미시닌과 병용한 항말라리아 나프토퀸의 인구 약리학: 용량 최적화Article Published on 2022-04-252024-08-01 Journal: Med Instrum [Category] 말라리아, [키워드] dose optimization malaria Population pharmacokinetics [DOI] 10.1128/aac.01696-21 PMC 바로가기
Infant Exposure to Dolutegravir Through Placental and Breast Milk Transfer: A Population Pharmacokinetic Analysis of DolPHIN-1태반 및 모유 전달을 통한 Dolutegravir에 유아 노출 : Dolphin-1의 인구 약동학 분석Online Only Articles Published on 2021-09-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 1:1 Breast breast milk breastmilk contributed CORD covariate covariates Coverage described diagnosed dolutegravir efavirenz Effect elimination rate evaluate exposure to fetal gestation HIV Human immunodeficiency virus immunodeficiency virus Infant infant pharmacokinetics inhibitory concentration investigated Maternal maternal plasma median median time milk mixed-effects modeling participant pharmacokinetic plasma plasma sample Population Population pharmacokinetics predicted Pregnancy presenting Prevent profiles Prophylactic Prophylaxis provided Randomized Rapid reduction in Result South Africa switch therapy threshold Transmission treatment initiation Uganda umbilical Umbilical cord waned was used women [DOI] 10.1093/cid/ciaa1861 PMC 바로가기 [Article Type] Online Only Articles
Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria피페라퀸의 반기계적 약리학적 및 약동학적 모델링: 플라스모디움 팔시파룸 혈액 단계 말라리아 자원봉사자 감염 연구Article Published on 2021-01-192024-08-08 Journal: Med Instrum [Category] 말라리아, [키워드] antimalarial agents Controlled human malaria infection Induced blood-stage malaria P. falciparum malaria Pharmacodynamics pharmacokinetics Pharmacology Piperaquine Population pharmacokinetics [DOI] 10.1128/AAC.01583-20 PMC 바로가기
Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling MethodPharmacology Published on 2021-01-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accumulated analyzed AUC biodistribution Blood Brain Clinical studies collected Concentration conducted Course cynomolgus macaque cynomolgus macaques decrease demonstrated descending described Determining distribution dosing regimen elimination rate constant euthanized evaluate faster fat group HCQ Hydroxychloroquine kidney liver lung lung tissue macaque modeling pharmacokinetic PK parameter plasma Population Population pharmacokinetics protein precipitation Quantitative receive red blood cells Result single dose spleen suggested time-dependent tissue tissues translation treatment regimen Urine Volume was determined [DOI] 10.3389/fphar.2020.602880 PMC 바로가기 [Article Type] Pharmacology
Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients클로로퀸의 인구 기반 메타 분석: COVID-19 환자의 클로로퀸 약동학 정보 제공Meta-Analysis Published on 2020-11-132022-08-31 Journal: European Journal of Clinical Pharmacology [Category] MERS, SARS, 신약개발, [키워드] Absorption approach approval best Chloroquine clearance Combination Concentration conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients described develop distribution dosing regimen Efficacy FIVE Meta-analysis Open-label patients with COVID-19 Pharmacodynamics pharmacokinetics phosphate PK data PK parameter PK parameters Population pharmacokinetics receiving regimen Result Safe safety margin Side-effects single-center study supplementary material treat understanding Volume volume of distribution [DOI] 10.1007/s00228-020-03032-6 PMC 바로가기 [Article Type] Meta-Analysis
Population Pharmacokinetics of Intravenous and Oral Acyclovir and Oral Valacyclovir in Pediatric Population To Optimize Dosing RegimensPharmacology Published on 2020-09-282024-09-04 Journal: Med Instrum [Category] 대상포진, [키워드] Antiviral agents children Population pharmacokinetics [DOI] 10.1128/AAC.01426-20 PMC 바로가기 [Article Type] Pharmacology
Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria아프리카의 비복합형 팔시파룸 말라리아 환자에서 피페라퀸의 심혈관 안전성 및 인구 약리학적 특성에 대한 다기관 집합 분석Article Published on 2020-04-202024-08-11 Journal: Med Instrum [Category] 말라리아, [키워드] antimalarial agents cardiovascular safety malaria Piperaquine population pharmacokinetic-pharmacodynamic model Population pharmacokinetics QT prolongation [DOI] 10.1128/AAC.01848-19 PMC 바로가기
An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment루메판트린과 일반적으로 사용되는 항레트로바이러스 치료제 간의 약물-약물 상호작용에 대한 개별 참가자 데이터 집단 약리학적 메타 분석Article Published on 2020-02-182024-08-11 Journal: Med Instrum [Category] 말라리아, [키워드] Drug-drug interactions Human immunodeficiency virus Lumefantrine Population pharmacokinetics Uncomplicated malaria [DOI] 10.1128/AAC.02394-19 PMC 바로가기
Population Pharmacokinetic Model to Assess the Impact of Disease State on Thalidomide Pharmacokineticsarticle Published on 2020-01-312024-09-01 Journal: Dent Cadmos [Category] 한센병, [키워드] clinical pharmacology modeling and simulation oncology pharmacokinetics and drug metabolism Population pharmacokinetics [Article Type] article
Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children아프리카 어린이의 단순한 팔수리움 말라리아 치료를 위한 아르테순산-메플로퀸 고정 용량 조합의 인구 약리학 및 약력학Research Published on 2019-04-182024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] artesunate dihydroartemisinin mefloquine Population pharmacokinetics [DOI] 10.1186/s12936-019-2754-6 PMC 바로가기 [Article Type] Research