Optimal strategies to screen health care workers for COVID-19 in the US: a cost-effectiveness analysisResearch Published on 2022-01-152022-10-31 Journal: Cost Effectiveness and Resource Allocation : C/E [Category] COVID-19, [키워드] Analysis Antigen applied approach Asymptomatic Care Characteristics clinical disease conducted cost-effectiveness COVID-19 defined determine HCW HCWs Health Health care Health care worker health care workers health-care identify IgG Immunity IMPROVE Infection infections Interaction outcome pandemic patients PCR PCR test PCR testing post-symptom onset Prevalence provide reduce Result Safe SARS-CoV-2 Screening sensitivity analysis supplementary material symptomatic Symptoms Transmission transmission of SARS-CoV-2 with COVID-19 yielding [DOI] 10.1186/s12962-021-00336-x PMC 바로가기 [Article Type] Research
SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe diseaseSARS-COV-2 스파이크-특이 적 메모리 B 세포는 중증 질환과 비교하여 비 체위 COVID-19 후 더 높은 수준의 T-BET 및 FCRL5를 발현한다.Research Article Published on 2021-12-222022-09-10 Journal: PLoS ONE [Category] SARS, 바이오마커, 진단, [키워드] activated analyzed B cell B cell memory B cell response B cells baseline levels both groups Cell changes in COVID-19 COVID-19 severity determine disease elicit elicited Express FcRL5 FIVE flow cytometry Frequency highlight Hospitalized IgG in both groups increased expression individual long-lived plasma cell long-lived plasma cells majority marker memory B memory B cell memory B cells phenotype Plasma cells post-symptom onset proportion RBD reactivity Receptor binding domain resulting robust SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 spike-specific severe COVID-19 severe disease Spike protein Spike receptor binding domain spike-specific IgG Spike-specific memory B cells symptom onset the SARS-CoV-2 these cell These cells two groups while [DOI] 10.1371/journal.pone.0261656 PMC 바로가기 [Article Type] Research Article
Anti-SARS-CoV-2 Immunoglobulin Isotypes, and Neutralization Activity Against Viral Variants, According to BNT162b2-Vaccination and Infection HistoryBNT162b2-백신 접종 및 감염 이력에 따른 Anti-SARS-CoV-2 면역글로불린 아이소타입 및 바이러스 변이체에 대한 중화 활성Immunology Published on 2021-12-172022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] activity Against anti-RBD Anti-RBD IgG antigen-specific antibody assays B.1 bead BNT162b2 BNT162b2 vaccine both group both groups coronavirus COVID-19 COVID-19 disease COVID‐19 cytopathic delta variant Delta variants disease domain dose expression pattern Fluorescence followed by Gamma highest history IgA IgG IgG levels IgM immunoassay Immunoglobulin immunoglobulins individual maximum mRNA vaccine multiplex immunoassay naïve neutralization Neutralization assay Neutralizing activity neutralizing capacity neutralizing titers Nucleocapsid proteins plasma post-symptom onset provided RBD Result SARS-CoV-2 SARS-CoV-2 antigen Serological assay single vaccine subject subjects suggested Support symptom onset three groups vaccination Vaccine variants Vero E6 Viral Viral antigen was determined [DOI] 10.3389/fimmu.2021.793191 PMC 바로가기 [Article Type] Immunology
Usefulness of ELISA Using Total Antibody against Plant-Expressed Recombinant Nucleocapsid Protein of SARS-CoV-2SARS-CoV-2의 식물 발현 재조합 뉴클레오캡시드 단백질에 대한 총항체를 이용한 ELISA의 유용성Research Article Published on 2021-11-242022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] 2019 novel coronavirus Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approaches assays can be used characteristic collected complementary coronavirus coronavirus disease COVID-19 Cutoff diagnosis of COVID-19 Diagnostic method diagnostic value disease Disease progression E. coli ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays Escherichia coli evaluated expressed Genetic highest IgG and IgM immune response immune responses Next-generation sequencing Novel coronavirus novel coronavirus disease nucleic acid nucleocapsid protein nucleoprotein occurred Patient plant plants post-symptom onset present produced PSO receiver operating characteristic recombinant Recombinant nucleocapsid protein respiratory reverse transcription reverse transcription-PCR robust ROC RT-PCR SARS-CoV-2 SD Biosensor sensitivity Sensitivity and specificity Seroconversion seroconversion rate seroconversion rates serological Serological assay Serosurvey serum serum sample serum samples severe acute respiratory syndrome Coronavirus Standard Total total antibody Viral viral nucleic acid [DOI] 10.1128/Spectrum.00672-21 PMC 바로가기 [Article Type] Research Article
Viable Severe Acute Respiratory Syndrome Coronavirus 2 Isolates Exhibit Higher Correlation With Rapid Antigen Assays Than Subgenomic RNA or Genomic RNAMicrobiology Published on 2021-11-122022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome Ag-RDT Ag-RDTs analytical sensitivity antigen-detection assays Cell Cell culture cohort study coronavirus coronavirus 2 COVID-19 Culture cycle threshold detect Detection sensitivity effective evaluated exhibited genomic genomic RNA gold immunoassay individuals Infection Infectivity isolate Isolation log negative controls Patient patients with SARS-CoV-2 PCR performed post-symptom onset Rapid Rapid diagnostic test respiratory respiratory sample RNA rRT-PCR SARS-CoV-2 sensitivity specificity Spread subgenomic RNA symptom onset tested Viable [DOI] 10.3389/fmicb.2021.718497 PMC 바로가기 [Article Type] Microbiology
Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections가벼운 SARS-COV-2 감염 환자의 순환 백혈구에 대한 지속적인 변화Comparative Study Published on 2021-11-082022-09-01 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] activated Asymptomatic asymptomatic infection C-reactive protein cellular change changes in Chemokine receptor chemokine receptors circulating consequence COVID-19 elevated expression Health immune activation Immune phenotype immunophenotype individual Infection Inflammation Inflammatory factor inflammatory factors investigated Mild mild or asymptomatic infections mild respiratory mild SARS-CoV-2 infection monocyte Monocyte activation persist phenotype polyclonal stimulation Post-infection post-symptom onset respiratory respiratory infections SARS-CoV-2 SARS-CoV-2 infections severe SARS severe SARS-CoV-2 significantly more survivor symptom onset systemic inflammation T-cell T-cells These data [DOI] 10.3390/v13112239 PMC 바로가기 [Article Type] Comparative Study
438. Phenotypic Differences Between Distinct Immune Biomarker Clusters During the ‘Hyperinflammatory’ Middle-Phase of COVID-19Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome adjusted age Algorithm Analysis approach association Astra Zeneca AstraZeneca Bar baseline Biomarker Bonferroni-corrected chronic pulmonary disease Cluster Clustering Clusters collected comorbid disease coronavirus COVID-19 COVID-19 cohort COVID-19 vaccine COVID19 Cutoff Data analysis diabete difference disease evaluated female figure Fisher’s exact test Frequency hospital hospitalized patients identify immunoassay individuals with COVID-19 Infection Inflammation inflammation marker Inflammatory Kruskal-Wallis test Logistic regression Lung disease machine material median Mild obesity offer Other performed phase Plasma level positive post-symptom onset Prevalence prevalent Prognosis Protein Result risk factor SARS-CoV-2 SARS-CoV-2 RT-PCR selected sensitivity analysis severity significance level specimen steroid treatment subject Support table The United States therapy topological data analysis Trial unique was performed was used were measured with COVID-19 [DOI] 10.1093/ofid/ofab466.637 PMC 바로가기 [Article Type] Poster Abstracts
Tocilizumab reduces COVID-19 mortality and pathology in a dose and timing-dependent fashion: a multi-centric study토 실리 주맙Article Published on 2021-10-052022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료법, [키워드] Administered appear cornerstone COVID-19 COVID-19 mortality Critical cytokine Cytokine storm dose doses drug IL-6 Inflammation Inflammatory Inflammatory marker inflammatory markers marker moderate Molecularly targeted therapy Mortality outcomes Outcomes research pathology pathway Patient patients patients with moderate performed post-symptom onset Prevent progression reduce reduced respiratory Respiratory Support retrospective Severity of disease shown significantly Stage stages Standard dose the stage Tocilizumab treated patients Variation variations Viral viral infection were measured [DOI] 10.1038/s41598-021-99291-z PMC 바로가기 [Article Type] Article
Dynamics of breast milk antibody titer in the six months following SARS-CoV-2 infectionSARS-CoV-2 감염 후 6개월 동안의 모유 항체 역가의 역학Article Published on 2021-09-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody titer Antibody titers breast milk Breastfeeding collected COVID-19 infection demonstrated detectable Donor Dynamics evaluated human milk humoral immune response IgA IgA response IgG level IgM antibodies IgM antibody Infants mother Post-infection post-symptom onset produced RBD RBD-specific IgG Receptor binding domain SARS-CoV-2 SARS-COV-2 infection serum serum sample serum samples Spike protein starting symptom onset the SARS-CoV-2 the spike protein while women [DOI] 10.1016/j.jcv.2021.104916 PMC 바로가기 [Article Type] Article
SARS-CoV-2 serology: Validation of high-throughput chemiluminescent immunoassay (CLIA) platforms and a field study in British ColumbiaSARS-CoV-2 혈청학: 브리티시컬럼비아에서 고처리량 화학발광 면역분석(CLIA) 플랫폼 및 현장 연구 검증Article Published on 2021-09-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 진단, 치료기술, [키워드] Abbott addition adjunct Antibody testing assays automated Care chemiluminescent immunoassay CLIA collected COVID-19 demonstrated diagnose diagnoses DiaSorin Disease prevalence Elecsy evaluated field Infection LIAISON molecular Negative predictive value Ortho Vitros outbreak Outbreak investigation outbreak investigations PCR PCR testing performed platform Positive predictive value positive predictive values post-symptom onset PPV predictive values Prevalence required Roche S1/S2 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody testing sensitivities sensitivity Sensitivity and specificity serologic serologic testing serology Siemen Siemens Specificities tested Total vaccine response validation validation study [DOI] 10.1016/j.jcv.2021.104914 PMC 바로가기 [Article Type] Article