preclinical studies – Page 2 – Communicable Diseases Research

COVID-19 vaccine candidates and vaccine development platforms available worldwide

Research article

Published on 2021-12-012022-10-05
Journal: Journal of Pharmaceutical Analysis [Category] 변종, 유전자 메커니즘,

Waning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models

비활성화된 SARS-CoV-2 백신 접종으로 인한 항체 약화는 붉은털 원숭이 폐렴 모델에서 항체 강화 면역병리학 없이 감염에 대한 보호를 제공합니다

Letter

Published on 2021-11-212022-09-10
Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 진단, 치료기술,

[키워드] absence acute phase acute respiratory syndrome acute respiratory syndrome coronavirus ADE alveolar anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody Antibody Response Antibody-dependent enhancement bronchioles Bronchoalveolar lavage Bronchoalveolar lavage fluid Cell cellular immunity clinical trial control group coronavirus Coronaviruses elevated epithelial Evidence evidence of humans IL-33 IL-8 immunology immunopathology inactivated Inactivated Vaccines Infection initial MCP-1 MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Mild mild to moderate moderate Mucus murine neutralizing antibody NHP no evidence of observation offer passive transfer Pneumonia polyclonal antibodies polyclonal antibody postvaccination preclinical studies preclinical study pulmonary immunopathology reported respiratory Respiratory disease respiratory diseases respiratory syndrome coronavirus rhesus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus subneutralizing antibodies supported transfer Typical vaccination Vaccine virus virus infection
[DOI] 10.1080/22221751.2021.2002670 PMC 바로가기 [Article Type] Letter

Non-clinical safety assessment and in vivo biodistribution of CoviFab, an RBD-specific F(ab′)2 fragment derived from equine polyclonal antibodies

Article

Published on 2021-11-142023-06-16
Journal: Toxicology and applied pharmacology [Category] MERS, SARS,

[키워드] biodistribution COVID-19 CoviFab Good laboratory practices preclinical studies
[DOI] 10.1016/j.taap.2021.115796 PMC 바로가기 [Article Type] Article

Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines-Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials

코로나바이러스 질병 2019 가속화 코로나바이러스 질병 2019 임상 시험에서 임상 평가를 위한 치료 개입 및 백신 선택 화합물

Review

Published on 2021-11-012022-09-11
Journal: Critical Care Medicine [Category] MERS, SARS, 신약개발, 진단, 치료제,

Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452

IgG-Fc 융합 코로나19 서브유닛 백신 AKS-452 개발

Article

Published on 2021-10-292022-09-11
Journal: Vaccine [Category] MERS, SARS, 변종, 진단,

[키워드] adjuvant adjuvants African Antigen APCS augmentation B.1.351 Cell cells clinical development Clinical studies clinical study clinical symptom Clinical symptoms comparable coronavirus COVID-19 COVID-19 pandemic development dose doses ENhance evaluated expectation Fc-fusion FcγR fusion protein greater huACE2 human IgG1 Fc IgG titers immunogenic immunogenicity Infection Infectious disease K18 live SARS-CoV-2 maintain mice Neonatal neutralization neutralizing IgG titer Neutralizing titer NHP NHPs non-human primate non-human primates pandemic phase preclinical studies preclinical study Prophylaxis receptor Receptor binding domain Region SARS-CoV-2 viral infection SARS-CoV-2 virus single dose South Spike protein subunit Subunit vaccine Support the SARS-CoV-2 USA-WA1/2020 Vaccine Vero-E6 cells Viral viral infection viral spike protein viral strain viral variant virus virus infection
[DOI] 10.1016/j.vaccine.2021.09.077 PMC 바로가기 [Article Type] Article

Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeys

Research article

Published on 2021-10-012022-10-05
Journal: Drug and alcohol dependence [Category] 비임상,

Hamsters as a Model of Severe Acute Respiratory Syndrome Coronavirus-2

중증 급성 호흡기 증후군 코로나바이러스-2의 모델로서의 햄스터

Review

Published on 2021-10-012022-09-11
Journal: Comparative medicine [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect age alveolar animal model animal models clinical disease Clinical outcome clinical outcomes Clinical sign Clinical signs contributed convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical death develop edema Effect Efficacy granulocyte hamster hamsters Health hemorrhage highlight human infection human infections humans Implications infected with SARS-CoV-2 Infection infiltration Injury inoculation interstitial lead lethargy lose weight Mesocricetus Model Mortality pandemic Pathogenesis Pneumonia preclinical studies preclinical study progression of disease pulmonary lesion pulmonary lesions Pulmonary pathology renal required respiratory Respiratory disease Respiratory system ruffled fur SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe infection severe infections Sex shown Spread Therapeutics Treatment vaccination virus variant virus variants weight while
[DOI] 10.30802/AALAS-CM-21-000036 PMC 바로가기 [Article Type] Review

The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance

Review

Published on 2021-09-072022-10-28
Journal: Animal Diseases [Category] COVID-19,

[키워드] accelerated acute respiratory syndrome animal model Antiviral approved Black Death Carboxylesterases caused cellular Clinical sign Concentration coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical cross deaths demonstrated drug Drug-drug interactions, interspecies difference Ebola Efficacy Efficacy and safety example food hydrolysis IMPROVE in vitro increase intravenously Mortality notable pandemic Pandemics parameter preclinical studies Randomized controlled trial Remdesivir SARS-CoV-2 Seven Spanish spike the United State therapeutic therapeutic option Toxicity treating COVID-19 Treatment Vaccines viral disease virus viruses
[DOI] 10.1186/s44149-021-00017-5 PMC 바로가기 [Article Type] Review

Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application

블레오마이신 유발 폐섬유증에 대한 간엽줄기세포의 유효성: 체계적인 검토 및 임상적용 시사점

Review

Published on 2021-08-232022-09-10
Journal: Stem Cell Research & Therapy [Category] MERS, 유전자 메커니즘,

[키워드] acute lung injury acute respiratory syndrome Bacterial Bleomycin cells clinical clinical evidence Clinical research clinical trial clinical trials collagen coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 Critically ill cytokine damaged disease effective Effectiveness endothelial epithelial cells expression Extracellular matrix Factors fibrosis growth Idiopathic pulmonary fibrosis IMPROVE inflammatory cell inflammatory cell infiltration Inflammatory cytokine Inflammatory response inhibiting interstitial interstitial disease IPF life lung Lung injury lung tissue Mesenchymal stem cells Middle East Middle East respiratory syndrome Migration MOST MSC MSCs paracrine Patient permeability poor prognosis potential mechanism preclinical studies preclinical study Prognosis pulmonary pulmonary fibrosis Quality of life reduce reducing Research respiratory SARS-CoV-2 SARS-COV-2 infection secretion Severe acute respiratory syndrome STEM stem cell stem cells Support systematic review therapeutic tissue repair transformation Treatment Trial viral-induced
[DOI] 10.1186/s13287-021-02551-y PMC 바로가기 [Article Type] Review

Are We Paving the Way to Dig Out of the “Pandemic Hole”? A Narrative Review on SARS-CoV-2 Vaccination: From Animal Models to Human Immunization

우리는 "팬데믹 홀"을 파헤치기 위한 길을 닦고 있습니까? SARS-CoV-2 백신 접종에 대한 내러티브 검토: 동물 모델에서 인간 예방 접종까지

Review

Published on 2021-07-302022-09-10
Journal: Medical Sciences [Category] 비임상, 임상,

[키워드] acute respiratory syndrome animal animal model animal models approach breath Clinical studies clinical study clinical trial clinical trials company contributed coronavirus coronavirus 2 COVID-19 develop effective vaccine extreme Government herd immunity high mortality rate Human human immunization humans immune responses Immunity immunization Inactivated Vaccines induce Infectious disease International mechanism Model morbidity and mortality narrative pandemic pathogen Preclinical preclinical studies preclinical study Prevent Protective provide Research respiratory review robust Safe SARS-CoV-2 SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spectrum therapeutic intervention therapeutic interventions Vaccination strategies Vaccine Vaccines Viral Viral vector vaccines virus
[DOI] 10.3390/medsci9030053 PMC 바로가기 [Article Type] Review