Environmental pathways affecting gene expression (E.PAGE) as an R package to predict gene-environment associationsArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Abstract affecting articles association biological processe Cell comprehensive resource COVID-19 criteria curated database dataset develop diabetes differentially expressed gene dysregulated enriched biological processes environmental factor environmental factors Gene Expression Gene Expression Omnibus Genes Infection initial Interaction lung cancer pathway predict R package retrieved rheumatoid arthritis selected signature smoking statistical analysis statistically tested [DOI] 10.1038/s41598-022-21988-6 PMC 바로가기
Firms’ COVID-19 Pandemic Exposure and Corporate Cash Policy: Evidence from ChinaResearch article Published on 2022-11-012022-10-05 Journal: Economic Modelling [Category] 변종, [키워드] Cash Cash holding China Chinese Corporate governance COVID COVID-19 COVID-19 pandemic decrease Evolution Excess cash exposure Financing friction Firms' COVID exposure fluctuations Impact impacted increase infected case influence Measures pandemic Placebo predict response robust severity translate [DOI] 10.1016/j.econmod.2022.105999 [Article Type] Research article
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE studyArticle Published on 2022-11-012022-11-15 Journal: Angiogenesis [Category] 바이오마커, 유전자 메커니즘, [키워드] 28-day mortality adult COVID-19 patients Analysis Bacterial Bacterial sepsis Biomarker clinical outcomes Clinical severity Cluster Cohort conditions coronavirus disease Correlation analysis COVID-19 COVID-19 patient dimension disease disease entity dysfunction endothelial Endothelial dysfunction explained Health healthy control high mortality Hospitalized hospitals host response impairment independent intubation marker Microcirculation Microscopy Microvascular dysfunction microvascular injury outcome analysis outcomes overlap patients plasma plasma protein predict predictor Protein proteome proteomic Proteomic signature proteomics quantified sepsis. Variation was performed was used were measured were used [DOI] 10.1007/s10456-022-09843-8 PMC 바로가기
A computational approach to biological pathogenicityArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] 바이오마커, [키워드] Accuracy adverse impact approach assessment Biochemistry Biomarkers clinical trial COVID-19 death Digital Digital genomic signature DNA DNA sequence energy event feature genomic Gibbs energy h-distance. Health Host humans hybridization machine machine learning machine learning model methodology microbe mitigate new strain oligonucleotide Other pandemic pathogen pathogenic Pathogenic relationship pathogenicity Pathogens/nonpathogens Perspective predict Quality reducing sensitivity Sensitivity and specificity Sickness specificity structural property [DOI] 10.1007/s00438-022-01951-w PMC 바로가기
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patientsArticle Published on 2022-11-012022-11-15 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval Affect anti-CD20 anti-CD20 treatment antibody Antibody Response Antibody titers B cell B cells B-cell B-cell depletion Blood booster cellular response Cohort correlated detectable develop Efficacy Guidance humoral identify IgG^{+} interleukin-13 Logistic regression median memory multiple sclerosis naïve no correlation Odds ratio Patient patients predict predictor Probability recent rituximab S1 domain SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Seroconversion T-cell Response treated Treatment turn vaccination vaccination. vaccine responses [DOI] 10.1111/ene.15492 PMC 바로가기
Evaluation of Procalcitonin’s Utility to Predict Concomitant Bacterial Pneumonia in Critically Ill COVID-19 PatientsArticle Published on 2022-11-012022-11-15 Journal: Journal of Intensive Care Medicine [Category] 바이오마커, [키워드] Antibiotic therapy AUC Bacteremia Bacterial Bacterial infection bacterial pneumonia baseline characteristics Concomitant conducted COVID-19 creatinine Critical Critical illness Critically ill patient Culture defined determine diagnosing diagnostic ENhance evaluate group hospitalized patients ICU ICU patient identify Ill in-hospital mortality intensive care intensive care unit Mortality multivariable multivariable model no difference no significant difference offer outcome Patient PCT Pneumonia positive predict Predictive procalcitonin procalcitonin. receiver operating characteristics Regression model retrospective cohort study ROC SARS-CoV-2 secondary bacterial pneumonia serum creatinine Severe COVID-19 pneumonia Severity of disease specificity threshold utility variable vital signs was used while with COVID-19 [DOI] 10.1177/08850666221108636 PMC 바로가기
Mathematical modeling to study the impact of immigration on the dynamics of the COVID-19 pandemic: A case study for VenezuelaResearch article Published on 2022-11-012022-10-05 Journal: Spatial and spatio-temporal epidemiology [Category] SARS, 변종, [키워드] Affect affected Asymptomatic carriers basic reproduction number COVID-19 COVID-19 pandemic decrease Epidemiology Evolution FIVE identify Immigration Intervention less mathematical mathematical modeling Mild number of infected outcome pandemic parameter Perspective predict public health SARS-CoV-2 SARS-CoV-2 virus Spread susceptible the disease the SARS-CoV-2 threshold transmission rate Venezuela [DOI] 10.1016/j.sste.2022.100532 [Article Type] Research article
Prevalence, trajectory over time, and risk factor of post-COVID-19 fatigueArticle Published on 2022-11-012022-11-15 Journal: Journal of psychiatric research [Category] 치료제, [키워드] bootstrap Characteristics Clarifying collected Course COVID-19 COVID-19 severity Depression depressive evaluated fatigue identify independent Intervention mechanism overlapping Patient physical post-COVID fatigue post-COVID syndrome predict predicted predictor Prevalence question rehabilitation remained reported symptom risk factor SARS-CoV-2 SARS-CoV-2. scale severity specific treatment Symptom Symptoms syndrome trajectory worsening [DOI] 10.1016/j.jpsychires.2022.08.008 PMC 바로가기
Elevated IL-18 predicts poor prognosis in critically ill COVID-19 patients at a Brazilian hospital in 2020-21Article Published on 2022-11-012022-11-15 Journal: Future Microbiology [Category] SARS, 바이오마커, [키워드] analyzed association Biomarker Brazil clinical outcomes contribute COVID-19 COVID-19 patient Critically ill Critically ill patient cross-sectional cytokine Deceased dysregulated evaluated exhibited hospital IL-18 immune immune response Inflammation Inflammatory response Innate immunity innate immunity. intensive care laboratory data marker Older Patient patients with COVID-19 Platelet poor prognosis predict quantified significantly higher sociodemographic data with COVID-19 [DOI] 10.2217/fmb-2022-0057 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기