Comparative effectiveness and durability of COVID-19 vaccination against death and severe disease in an ongoing nationwide mass vaccination campaign진행중인 전국적인 대규모 예방접종 캠페인에서 COVID-19 사망 및 중증 질환에 대한 예방접종의 비교 효과 및 지속성Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% confidence interval Active surveillance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Ad26.COV2.S adjusted age all age groups approved BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 Cohort Cohort studies Comparative coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccines death dose doses Effectiveness effort immunogenicity intubation mass vaccination morbidity Mortality mRNA mRNA-1273 National of BNT162b2 offer offered pandemic prevented reduce registry data remained SARS-CoV-2 severe disease study period vaccinate vaccination Vaccine vaccine effectiveness variant variants waned were used [DOI] 10.1002/jmv.27934 PMC 바로가기 [Article Type] Article
Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived VariantsArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 Basis binding binding affinity binding mechanism changes in complexes coronavirus Cross-species transmission cryo-EM cryo-EM structure demonstrated examined expressing F486L facilitate highlight hosts Human human cell human monoclonal antibodies humans identify indicated Infection information Interaction mechanism Microscopy mink molecular mechanism Mutation N501T neutralized prevented Protein pseudovirus RBD RBD variant RBD variants receptor reduced residue SARS-CoV-2 SARS-CoV-2 variant sera Structure the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 transmitted variant variants virus entry viruses Y453F [DOI] 10.1128/jvi.00814-22 PMC 바로가기
Antigenic cartography using sera from sequence-confirmed SARS-CoV-2 variants of concern infections reveals antigenic divergence of OmicronArticle Published on 2022-09-132022-11-15 Journal: Immunity [Category] SARS, 변종, 진단, [키워드] antibodies antigenic antigenic cartography circulating variants convalescent COVID-19 D614G death Effectiveness elicited Evolution had more Hospitalization Immune escape Immunity individual Infection neutralization Neutralizing activity omicron other variants Patient prevented question responses reveal SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant Seasonal influenza sera strain vaccination Vaccine Vaccines variants of concern virus VoC VOCs [DOI] 10.1016/j.immuni.2022.07.018 PMC 바로가기
SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy PathogenesisArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 acute respiratory distress alveolar angiotensin-converting enzyme 2 binding blocked Blood coagulation Capillaries cell types cellular co-culture Coagulopathy communication Contact COVID-19 COVID-19 patient Delta Disease progression drug DTNB endothelial Endothelial cell endotheliopathy Evidence Express expression extrinsic pathway Factor Factor-V fibrinogen functional groups had no Human human lung human lung endothelial cells humans induce infect inhibited inhibitor interactions investigated leukocyte mechanism Microvascular thrombosis neutrophil Neutrophils Pathogenesis pathway Patient potential mechanisms prevented Protein pulmonary complication Pulmonary endothelium recombinant S-protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 variant SARS-CoV-2 virion secretion severe lung injury significantly increased spike syndrome target cell TFPI therapeutic strategy thrombin thrombomodulin thrombosis tissue Tissue Factor Transcriptional upregulation vascular endothelial cell vessel Wuhan [DOI] 10.3390/ijms231810436 PMC 바로가기
SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19Article Published on 2022-09-072022-10-06 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 ACE2 protein cells contribute correlated COVID-19 COVID-19 cohort Degradation E3 ligase ENhance entry receptor epithelial epithelial cell epithelial cells Exosome Exosomes humanized Infection Live virus lysine MAP4K3/GLK mice overexpression pathogenesis of COVID-19 patients phosphorylated prevented pseudovirus infection residue RNA-sequencing SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Serine serum exosome severity stability the SARS-CoV-2 transported UBR4 UBR4. Vesicle with COVID-19 [DOI] 10.15252/emmm.202215904 PMC 바로가기 [Article Type] Article
UV-C Light Completely Blocks Aerosol Transmission of Highly Contagious SARS-CoV-2 Variants WA1 and Delta in HamstersArticle Published on 2022-09-062022-11-16 Journal: Environmental science & technology [Category] SARS, 변종, [키워드] activities adhere aerosol block COVID COVID19 Delta effective Effectiveness element hamster individual investigated LIGHT measure Population Prevent prevented reduce risk SARS-CoV-2 SARS-CoV-2 transmission Spread susceptible Syrian Golden hamsters Transmission transmission of SARS-CoV-2 ultraviolet light UV-C virus WA1 wavelength [DOI] 10.1021/acs.est.2c02822 PMC 바로가기
Influence of Effort-based Reward Training on Neuroadaptive Cognitive Responses: Implications for Preclinical Behavioral Approaches for Depressive SymptomsResearch article Published on 2022-09-012022-10-05 Journal: Neuroscience [Category] 비임상, [키워드] approach approaches assigned BDNF brain-derived neurotrophic factor (BDNF) cognitive Dehydroepiandrosterone (DHEA) depressive depressive symptom Depressive symptoms disorder Efficacy Effort-based Reward (EBR) examination exhibited faster female group immunoreactivity incidence rate influence lack Lateral habenula (LHb) male males mechanism mechanisms no significant effect offer Preclinical Preclinical model of depression prevented provide response therapeutic intervention Therapies training Trial trials were assessed [DOI] 10.1016/j.neuroscience.2022.08.002 [Article Type] Research article
Multisystem inflammatory syndrome in a fully vaccinated 18-year-old without known SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-16 Journal: Pediatric Rheumatology Online Journal [Category] 변종, [키워드] Acute respiratory infection acute respiratory syndrome antibody children COVID-19 COVID-19 pandemic differential diagnosis Effectiveness Evolution febrile female healthy child heart failure include Infection Inflammatory initial International MIS-C nucleocapsid omicron outbreak pediatric prevented reported SARS-CoV-2 SARS-COV-2 infection severity Shock syndrome thought vaccination variant [DOI] 10.1186/s12969-022-00730-6 PMC 바로가기
A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal deliveryArticle Published on 2022-08-302022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Administered antibody approved B.1.1.529 B.1.617.2 broad-spectrum antivirals characterized circulating Clinical outcome Clinical use coronavirus Delta delta variant dosage drug effective Efficacy ENhance half-maximal inhibitory concentration hamster IC50 inhibit Intravenous injection knowledge Lungs mutants nasal nebulized neutralizing antibody omicron overcome Patient prevented Prophylactic provide Replication SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant therapeutic therapeutic efficacy therapy Treatment Vaccine variant virus-neutralizing VoC VOCs [DOI] 10.1038/s41392-022-01135-3 [Article Type] Article
Women’s EmotionS, Trauma and EmpowErMent (W-ES.T.EEM) study protocol: a psychoeducational support intervention for victims of domestic violence – a randomised controlled trialArticle Published on 2022-08-252022-10-05 Journal: BMJ Open [Category] 임상, [키워드] Administered adult psychiatry Affect anonymously approach approved articles behavioural blind center change control condition COVID-19 COVID-19 outbreak COVID-19 pandemic Efficacy Ethics ethics committee experimental group face-to-face interventions family Intervention Intimate partner violence Italy manuscript Mental online psychological intervention participant peer-reviewed physical prevented protocol psychoeducational Psychoeducational intervention randomised controlled trial Randomly receiving recruited reported Research Study protocol Support Telemedicine therapy treatment as usual university widespread women written Informed Consent [DOI] 10.1136/bmjopen-2021-060672 PMC 바로가기 [Article Type] Article