A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a PartArticle Published on 2022-10-182022-11-15 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome All adverse event Asymptomatic baseline clinical coronavirus coronavirus disease COVID-19 Culture demonstrated double-blind Efficacy and safety ensitrelvir fumaric acid greater group groups intention-to-treat population Japan Japanese log median time Mild Mild-to-moderate moderate multicenter novel oral Part Patient phase phase 2/3 Placebo positive Primary outcome proof-of-concept study protease Protease inhibitor Randomized receive reduced registry Result S-217622 SARS-CoV-2 SARS-CoV-2 3C-like protease inhibitor SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral the SARS-CoV-2 tissue Treatment viral clearance Viral RNA viral titer viral titer. [DOI] 10.1128/aac.00697-22 PMC 바로가기
The safety of esophageal cancer surgery during COVID-19Article Published on 2022-10-142022-11-16 Journal: Medicine [Category] meta-analysis, [키워드] 95% confidence interval anastomotic Blood Cancer Chinese Cochrane Library complications conducted coronavirus disease COVID-19 COVID-19 pandemic database determine evaluate Evidence Fang heterogeneity Hospital stay ICU identify Infrastructure intensive care journal mean difference Meta-analysis Mortality outcome outcomes pandemic Patient postoperative Primary outcome random effect model readmission Registered researchers risk risk ratio secondary outcome surgical systematic review Trial was performed Web of Science were used [DOI] 10.1097/MD.0000000000030929 PMC 바로가기
Comparison of the safety and immunogenicity of the BNT-162b2 vaccine and the ChAdOx1 vaccine for solid organ transplant recipients: a prospective studyArticle Published on 2022-10-132022-11-15 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome administration anti-RBD antibody BNT-162b2 ChAdOx1 vaccine coronavirus coronavirus disease COVID-19 diabetes disease dose doses Effect Efficacy first dose IgG Immunity vaccine Immunoglobulin Infection kidney kidney transplant liver liver transplant Liver transplant. Local no difference older patient Organ transplant Patient platform Primary outcome Prospective Study prospectively studied question recipient reduced resulting SARS-CoV-2 SARS-CoV-2 vaccination second dose secondary endpoint seroconversion rate shown side significantly solid organ transplant spread to systemic adverse event the RBD the spike protein the vaccine trials unresponsiveness vaccination Vaccine vaccine doses vaccine platform [DOI] 10.1186/s12879-022-07764-x PMC 바로가기
Sex differences in determinants of COVID-19 severe outcomes – findings from the National COVID Cohort Collaborative (N3C)Article Published on 2022-10-122022-11-15 Journal: BMC Infectious Diseases [Category] 바이오마커, [키워드] absolute lymphocyte absolute neutrophil adjusted adjusted odds ratio Admission age Analysis association averaged Biomarker Biomarkers both sexes CCI Charlson Comorbidity Index comorbid condition Comorbidities Comorbidity components COVID COVID-19 COVID-19 severity CRP death death rate defined determinant disease Elevation examined ferritin Health highlight hospital Hospitalized IMV Inflammation inflammatory biomarkers Invasive mechanical ventilation lab value Liver disease Logistic regression LOS lymphocytopenia magnitude male medication men men and women moderate to severe Mortality Myocardial infarction N-terminal neutrophil outcome Patient peptide Platelet Platelets predictor previous study Primary outcome procalcitonin Protein remained renal Research retrospective cohort risk risk factor risk of death secondary outcome Sex Sex difference sex differences. significantly solid tumor with COVID-19 women [DOI] 10.1186/s12879-022-07776-7 PMC 바로가기
Respondent Fatigue Reduces Dietary Diversity Scores Reported from Mobile Phone Surveys in Ethiopia during the COVID-19 PandemicArticle Published on 2022-10-062022-11-16 Journal: The Journal of Nutrition [Category] 비임상, [키워드] assigned collected comparison country COVID-19 COVID-19 pandemic decrease dietary dietary diversity Diversity Effect Ethiopia Ethiopian experiment fatigue FIVE fixed food group groups highlighting Impact information measure Metrics Mobile Older outcome phone survey Primary outcome question Randomized Randomly reported respondent response response fatigue. score secondary survey trade-off Volume were assessed women [DOI] 10.1093/jn/nxac153 PMC 바로가기
Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled TrialArticle Published on 2022-10-062022-11-15 Journal: The Journal of Nutrition [Category] COVID19(2023년), SARS, 바이오마커, [키워드] adhesion molecules age anti-inflammatory effect Antigen assigned baseline Biomarker Blood BMI C-reactive protein CDC chronic condition coin toss Concentration conducted Controlled coronavirus disease covariates COVID-19 COVID-19 complications COVID-19, SARS-COV-2 Cytokines diagnosed with COVID-19 Diagnosis dietary supplements double-blind dysregulated immune response Effect exacerbate ferritin group Health IL-1β IL-2 IL-6 implicated indicated individual infected with COVID-19 infections infectious conditions Inflammation inflammatory mediator intercellular Linear regression model mechanism Multiple outcomes P-selectin palmitoylethanolamide palmitoylethanolamide. participant Placebo placebo tablet positive test result Primary outcome produced proinflammatory promote randomized placebo-controlled trial Randomly receive reduced reported RT-PCR secretion severity Sex significantly stratified treatment effect [DOI] 10.1093/jn/nxac154 PMC 바로가기
Outcome of COVID-19 in Kidney Transplant Recipients Through the SARS-CoV-2 Variants Eras: Role of Anti-SARS-CoV-2 Monoclonal AntibodiesArticle Published on 2022-10-042022-11-15 Journal: Transplant International [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Administered Charlson Comorbidity Index complications COVID-19 COVID-19-related symptom death Diagnosis dose early administration early treatment Epidemiology Hospitalization incidence increased risk Infection kidney Kidney transplantation mAb mAbs monoclonal monoclonal antibodies monoclonal antibody Multivariate analysis Omicron variant onset of symptoms outcome Patient primary endpoint Primary outcome recipient role SARS-CoV-2 SARS-COV-2 infection significant decrease study period the SARS-CoV-2 Transplant vaccination vaccination. [DOI] 10.3389/ti.2022.10721 PMC 바로가기
Magnitude and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Household Transmission: A Longitudinal Cohort StudyArticle Published on 2022-10-032022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome confidence interval Contact coronavirus coronavirus 2 cumulative determinant Epidemiology evaluated household household contact household contacts household transmission incidence increased risk increasingly individual Infection infectious viral shedding. Intervention longitudinal magnitude nasal occurred populations Primary outcome reduce respiratory risk of infection RNA SARS-CoV-2 SARS-COV-2 infection specimen Symptom symptom onset symptomatic symptomatic SARS-CoV-2 infection Transmission transmission of SARS-CoV-2 vaccination viral shedding [DOI] 10.1093/cid/ciac545 PMC 바로가기
Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patientsArticle Published on 2022-10-032022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 anti-TNF antibody Autoimmune booster dose cellular immunity Control COVID-19 case COVID-19 cases cumulative Decline decrease delta variant dose geometric mean titer IgG positivity IgG response Immunity immunogenicity immunosuppressive Inactivated vaccine incidence individuals Logistic regression analysis male multivariate Neutralizing Neutralizing antibodies outcome Patient patients Prednisone Primary outcome reduce reduction in rheumatic disease SARS-CoV-2 IgG SARS-CoV-2 immunity secondary Spread stability Therapies Vaccine vaccine dose [DOI] 10.1038/s41467-022-33042-0 PMC 바로가기
Comparison of antibody response durability of mRNA-1273, BNT162b2, and Ad26.COV2.S SARS-CoV-2 vaccines in healthcare workersArticle Published on 2022-10-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] Ad26.COV2.S Administered age analysis of variance Anti-spike anti-spike antibody antibody level Antibody Response Antibody responses blood draws BNT162b2 BNT162b2 vaccine booster dose COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccinations Effectiveness enzyme-linked immunosorbent female group healthcare worker Immunosuppression interquartile range IQR Linear regression median mRNA-1273 mRNA-1273 vaccine neutralizing antibody outcome participant Participants Primary outcome SARS-CoV-2 SARS-CoV-2 vaccine significantly significantly higher vaccination Vaccine vaccine effectiveness. variable [DOI] 10.1016/j.ijid.2022.08.022 PMC 바로가기