Efficacy and harms of tocilizumab for the treatment of COVID-19 patients: A systematic review and meta-analysis코로나19 환자 치료를 위한 토실리주맙의 효능과 유해성: 체계적 고찰 및 메타분석Meta-Analysis Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] 임상, 진단, [키워드] 95%CI adverse event adverse events AEs all-cause mortality analyses antibody Arm ARMS benefit bleeding Clinical improvement Clinical outcome Cohort cohorts Controlled trial COVID-19 COVID-19 adult patient COVID-19 adult patients database disease severity Effect evaluated Evidence Hospitalized hospitalized COVID-19 patients IL-6 impacted inverse main analyses mechanical ventilation Meta-analysis methodology moderate neutropenia nine no significant difference Other outcome performed Placebo Primary outcomes Probability Quality Random-effects meta-analysis Randomized controlled trials RCT RCTs receptors reduced risk risk of bia RoB searched severe AEs significant difference significantly Standard of care Subgroup analyses subgroup analysis systematic review TCZ thrombotic thrombotic event Thrombotic events Tocilizumab Treatment Weighting worsening [DOI] 10.1371/journal.pone.0269368 PMC 바로가기 [Article Type] Meta-Analysis
Protecting the mental and physical well-being of frontline health care workers during COVID-19: Study protocol of a cluster randomized controlled trialCOVID-19 기간 동안 최전선 의료 종사자의 정신적, 육체적 웰빙 보호: 클러스터 무작위 통제 시험의 연구 프로토콜Article Published on 2022-06-012022-09-11 Journal: Contemporary clinical trials [Category] COVID19(2023년), SARS, 임상, [키워드] acceptability addition AID anxiety symptoms assigned Burnout Cluster Controlled trial COVID-19 COVID-19 pandemic Depression disorder distress Effectiveness eight Evidence feasibility first aid HCW Health care Health care worker health care workers health center Healthcare workers hospital implementation include initial Injury Intervention Mental mental health Moral distress pandemic physical Posttraumatic Stress posttraumatic stress disorder Primary outcome Primary outcomes problems Protecting protocol Psychological Psychological distress Randomized controlled trial Randomly recruit Resilience Result risk secondary outcome Secondary outcomes selected Stress Support turn usual care Well-being [DOI] 10.1016/j.cct.2022.106768 PMC 바로가기 [Article Type] Article
Safety of COVID-19 vaccines in patients with non-communicable diseases: a protocol for systematic review and meta-analysis of randomised controlled trials의사 소통 할 수없는 질병 환자의 Covid-19 백신의 안전성 : 체계적인 검토 및 무작위 대조 시험의 메타 분석을위한 프로토콜Article Published on 2022-05-242022-08-31 Journal: BMJ Open [Category] COVID19(2023년), MERS, meta-analysis, SARS, 임상, [키워드] Adverse adverse event adverse events Adverse reaction Adverse reactions Affect analysed approval best carried caused Cochrane Library conducted COVID-19 COVID-19 pandemic COVID-19 vaccine Data analysis data extraction dose Ethical approval Ethics event Evidence global pandemic heterogeneity identify item Local Meta-analysis Non-communicable disease non-communicable diseases not limited outcome Participation Patient peer-reviewed Primary outcome Primary outcomes PROSPERO protocol public health randomised controlled trial Randomised controlled trials RCT RCTs Registered registration number Reporting researchers resolved review risk of bia Safety Selection significantly systematic review systemic adverse event therapeutic strategy threat Trial trials vaccination Vaccine Vaccines Web of Science Withdrawal [DOI] 10.1136/bmjopen-2021-057233 PMC 바로가기 [Article Type] Article
SARS-CoV-2 humoral immune response in patients with cardiovascular risk factors: the COmmunity Cohort Study protocol심혈관 위험 인자가 있는 환자의 SARS-CoV-2 체액성 면역 반응: 커뮤니티 코호트 연구 프로토콜Article Published on 2022-05-192022-09-11 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Adult patients anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines antibody approved baseline blood sample cardiovascular cardiovascular risk cardiovascular risk factors clinics Cohort collected Community conducted Contact contact with COVID-19 death defined detectable determine disseminate eligible Epidemiology Ethics ethics committee exposure exposure to face-to-face contact follow-up time Health care humoral immune response IgG antibody immunology Inclusion International Local Memorandum mixed-effects model morbidity National neutralising Neutralising Antibodies neutralising antibody outcome pandemic participant Patient peer-reviewed Prevent primary care Primary outcome Primary outcomes prospective cohort study protocol questionnaire recruitment Registered Research Sample size SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens secondary Secondary outcomes Seroconversion service South strength Study protocol vaccination website [DOI] 10.1136/bmjopen-2022-061345 PMC 바로가기 [Article Type] Article
SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis감염, 증상 및 중증 COVID-19에 대한 SARS-CoV-2 백신 효과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-05-072022-09-11 Journal: BMC Infectious Diseases [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] 95% CI Ad26 Ad26.COV2.S age approach assessment booster vaccination can be used certainty Cohort studies cohort study completion Controlled controlled trials coronavirus disease COVID-19 database declined defined dependent on development Effectiveness Efficacy Evidence Evolution Evolution of SARS-CoV-2 FIVE Health Organization Immunity individual individuals Infection literature Meta-analysis outcome Primary outcomes public health random-effects model Randomized controlled trial remained representing Risk of bias SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine searched selected severe COVID-19 symptomatic symptomatic COVID-19 systematic review systematic reviews These data vaccination Vaccine vaccine effectiveness variant variants virus waned waning immunity was performed was used World Health Organization [DOI] 10.1186/s12879-022-07418-y PMC 바로가기 [Article Type] Meta-Analysis
Web-based exercise interventions for patients with depressive and anxiety disorders: a systematic review of randomized controlled trials우울 및 불안 장애 환자를 위한 웹 기반 운동 중재: 무작위 대조 시험의 체계적인 검토Article Published on 2022-05-012022-09-11 Journal: Revista brasileira de psiquiatria (São Paulo, Bra [Category] 비임상, 임상, [키워드] age Anxiety anxiety disorders anxiety symptom anxiety symptoms approach article assessment available data benefit breath changes in Cochrane Library Control controlled trials controls coronavirus disease Coronavirus disease 2019 COVID-19 cumulative database Depression depressive depressive symptom Depressive symptoms development Effect eligible Evidence Exercise intervention inclusion criteria involved item outcome pandemic participant Patient PICOS Potential treatment Primary outcomes PROSPERO provided Randomized Randomized controlled trial Randomized controlled trials recommendation Registration registration number Reporting review risk of bia SciELO searched strength strength training systematic review systematic reviews Web of Science women yoga [DOI] 10.1590/1516-4446-2021-2026 PMC 바로가기 [Article Type] Article
Convalescent plasma may not be an effective treatment for severe and critically ill covid-19 patients: A Systematic Review & Meta-Analysis of Randomized Controlled Trials회복기 혈장은 중증 및 중환자 코로나19 환자에게 효과적인 치료법이 아닐 수 있습니다: 무작위 대조 시험의 체계적인 검토 및 메타 분석Review Published on 2022-05-012022-09-11 Journal: Heart & lung : the journal of critical care [Category] 임상, 치료법, [키워드] 95% CI Clinical improvement conducted Controlled controlled trials convalescent plasma Convalescent plasma therapy convalescent plasma treatment Corona corona virus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill database effective evaluate Meta-analysis moderate mortality risk no significant difference Patient plasma Primary outcome Primary outcomes Randomized controlled studies randomized controlled study Randomized controlled trial reduce review severe and critically ill COVID-19 patients systematic review Treatment Virus Disease [DOI] 10.1016/j.hrtlng.2022.01.019 PMC 바로가기 [Article Type] Review
A large-scale meta-analytic atlas of mental health problems prevalence during the COVID-19 early pandemicCOVID-19 초기 전염병 동안 정신 건강 문제 유병률에 대한 대규모 메타 분석 지도Meta-Analysis Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] affected age Analysis Anxiety conducted country COVID-19 COVID-19 infection COVID-19 infection status COVID-19 pandemic Cross-sectional studies database Depression female followed by General population Health Organization healthcare healthcare worker Healthcare workers highest ideation Impact Infection Intervention median Mental disorder Mental Disorders mental health mental health burden mental health problem mental health problems Meta-analysis mitigate observational studies observational study outcome pandemic people with COVID-19 Prevalence prevalent Primary outcomes problem problems Sensitivity analyses Sex somatic disorder somatic disorders stratified Stress Subgroup analyses subgroup analysis subgroups Suicidal ideation Symptom Symptoms systematic review unique World Health Organization [DOI] 10.1002/jmv.27549 PMC 바로가기 [Article Type] Meta-Analysis
The efficacy of Narrative Exposure Therapy for Children (KIDNET) as a treatment for traumatized young refugees versus treatment as usual: update to the study protocol for the multi-center randomized controlled trial YOURTREAT외상을 입은 어린 난민에 대한 치료로서 어린이를 위한 내러티브 노출 치료(KIDNET)의 효능 대 평소 치료: 다기관 무작위 대조 시험 YOUTREAT에 대한 연구 프로토콜 업데이트Article Published on 2022-04-272022-09-11 Journal: Trials [Category] 임상, [키워드] adolescents aggravate Amendment Care change children clinical clinical trial Compliance conduction COVID-19 pandemic Deutsches Register Klinischer Studien diagnostic effective Efficacy Evidence exposure Exposure Therapy feasible Frame Germany Health Health care Health care system include increase Mental mental health mental health care Methodological quality narrative Narrative Exposure Therapy for Children (KIDNET) pandemic Participants Post-traumatic stress disorder Pragmatic Primary outcome Primary outcomes problems Randomized controlled trial reduction refugees risk secondary outcome situation Stress Study protocol Tau therapy Time frame Treatment treatment as usual Trial [DOI] 10.1186/s13063-022-06288-8 PMC 바로가기 [Article Type] Article
A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)SARS-CoV-2(COVID-19)에 감염되어 침습적 기계 환기 없이 병원에 입원한 환자에서 이카티반트의 효능과 안전성을 평가하기 위한 다기관, 공개 라벨, 무작위, 개념 증명 II상 임상 시험: 연구 프로토콜(ICAT-COVID)Article Published on 2022-04-122022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 ACE2 acute respiratory distress acute respiratory distress syndrome Antigen ARDS attacks bradykinin caused Clinical efficacy clinical status clinical trial ClinicalTrials Comorbidity control group COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia Cytokine storm death Diagnosis discharge discharged doses effective Effectiveness Efficacy Efficacy and safety eligible Endothelial cell endothelial cells EudraCT Evidence evidence of expected experimental group global pandemic Healthcare system Healthcare systems hospital Hospitalized Icatibant include infected with SARS-CoV-2 Inflammatory response inhibiting invasive mechanical Invasive mechanical ventilation Mortality multicenter Open-label outcome Patient patients hospitalized Pneumonia Primary outcomes protease pulmonary infiltrates Radiographic randomization Randomized receive receptor receptor antagonist respiratory distress Respiratory distress syndrome RT-PCR Safe Sample size SARS SARS-CoV-2 secondary Secondary outcomes Spain Standard of care Study protocol subcutaneously Symptoms syndrome the SARS-CoV-2 the WHO thought treat Treatment viral infection with COVID-19 working hypothesis [DOI] 10.1186/s13063-022-06219-7 PMC 바로가기 [Article Type] Article