Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2 + Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver DysfunctionMedicine Published on 2021-04-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome analyzed angiotensin-converting enzyme 2 binding caused cell death cell population China cirrhotic liver co-expression Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient Cytokine storms Deleterious develop disease fetal FIVE globe healthy host cell human liver impair implicated indicated liver Liver cirrhosis liver dysfunction liver tissue mammalian mammalian cell pandemic pathophysiology Patient prevalent progenitor Protein receptor reported respiratory symptom Respiratory virus infection RNA-Seq SARS-CoV-2 scRNA-seq serine protease significantly Single Cell single-cell RNA-seq spike the S protein tissue TMPRSS2 transmembrane serine protease Trop2 viral infection [DOI] 10.3389/fmed.2021.603374 PMC 바로가기 [Article Type] Medicine
Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells내피 전구체의 다차원 단백질체 접근은 CD19 세포로 제한된 KDR의 발현을 보여줍니다Clinical Trial Published on 2021-04-012022-08-31 Journal: Stem cell reviews and reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] absence Abstract approach approach artificial heart B-lymphocyte B-lymphocytes Bioprosthetic total artificial heart Blood C-kit cadherin candidate cardiovascular disease cardiovascular diseases CD133 CD14 CD19 CD34 CD45 Cell cell population cells cellular circulating circulation classic complementary Cord blood COVID-19 COVID-19 severity Critical critical COVID-19 patient cytometric Cytometry demonstrated described Elimination endothelial Endothelial progenitor cell Endothelial progenitor cells Endothelial progenitors evaluate events expresse expressed expressing expression Flow flow cytometry healthy imaging immature induce involved KDR lead Lineage Lymphocytes marker moderate monocyte Monocytes multidimensional one patient Patient performed Peripheral blood phenotype Population positive cell progenitor progenitor cell progenitor cells proteomic quantified redistribution Restricted Single Cell STEM stem cell stem cells subpopulation subset Subtypes vasculogenesis VE-cadherin VEGFR-2/KDR. [DOI] 10.1007/s12015-020-10062-1 PMC 바로가기 [Article Type] Clinical Trial
Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen박쥐에서 SARS-CoV-2의 진화에서 자연 선택은 일반 바이러스와 고도로 유능한 인간 병원체를 만들었습니다Research Article Published on 2021-03-122022-08-13 Journal: PLoS Biology [Category] Biology and Life Sciences, Fulltext, SARS, 유전자 메커니즘, 조류인플루엔자, 치료기술, [키워드] accompanied acting acute respiratory syndrome coronavirus adaptive Analysis ancestor Anti-viral Antiviral base bat bat Sarbecovirus bats can not Cell Coinfection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CpG CpG composition detect early phase Evidence evidence of Evolution Evolution of SARS-CoV-2 horseshoe bats Host hosts Human human pathogen humans include involved Lineage lineages mechanism moderate natural natural selection nucleotide nucleotides pandemic positive Positive selection progenitor recombinant Recombination required respiratory reveal RmYN02 Sarbecoviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support the cells the early SARS-CoV-2 Transmission virus viruses while [DOI] 10.1371/journal.pbio.3001115 PMC 바로가기 [Article Type] Research Article
Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients인간 적혈구 전구 세포가 SARS-CoV-2에 직접 감염됨: 중증 COVID-19 환자의 적혈구 생성에 대한 시사점Report Published on 2021-02-052022-09-10 Journal: Stem Cell Reports [Category] MERS, SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression Anemia Bone marrow cause CD34 Cell cells circulating circulation clinical symptom Clinical symptoms colonies colony contribute COVID-19 COVID-19 patient COVID19 defined erythroid erythropoiesis expansion hemoglobin highest Human human hematopoietic stem/progenitor cells hypoxia impairing increase in induce infect Infection initial intensive care local inflammation nucleated red cells progenitor progenitor cell red blood cell red blood cells reduced SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient Spread Stress target cell the patient these cell These cells tissues TMPRSS2 virus [DOI] 10.1016/j.stemcr.2021.02.001 PMC 바로가기 [Article Type] Report
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair폐 항상성 및 복구에서 폐포 유형 II 세포의 이종 그룹Review Published on 2020-12-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] SARS, 유전자 메커니즘, [키워드] allergens alveolar alveolar epithelium Alveolar Type II alveoli AT2 cause Cell cells coronavirus disease Coronavirus disease 2019 COVID-19 differentiation finding function group heterogeneity homeostasis Injury integrity Lineage lung Lung disease lung; maintain marker gene mechanism pandemic Pathogens pathological conditions progenitor repair revelation scRNA-seq Single-cell RNA-sequencing stem cell stem cells subpopulation target targets tissue type II cells. virus [DOI] 10.1152/ajpcell.00341.2020 PMC 바로가기 [Article Type] Review
Development of solitary chemosensory cells in the distal lung after severe influenza injuryArticle Published on 2019-06-012023-06-23 Journal: American journal of physiology. Lung cellular and [Category] 신종인플루엔자, [키워드] chemosensory Inflammation Influenza progenitor Tuft [DOI] 10.1152/ajplung.00032.2019 PMC 바로가기
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article