An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde traffickingSARS-CoV-2 스파이크의 확장된 모티프는 역행 인신매매에서 숙주 코토머의 결합 및 방출을 조절합니다Article Published on 2022-02-082022-09-10 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] bats binding Binding assays Biophysical methods canonical complex conserved COPI Critical Crystallography cytosolic determinant dibasic ERGIC Host humans identify implication in silico analysis interact modulate motif Mutagenesis pangolins progeny Protein structure predictions proteome released reservoirs residue SARS-CoV-2 selectivity sequence Spike protein Spike proteins subunit the SARS-CoV-2 Viral X-ray crystallography zoonotic β-coronavirus β-Coronaviruses [DOI] 10.1038/s42003-022-03063-y PMC 바로가기 [Article Type] Article
SARS-CoV-2: Ultrastructural Characterization of Morphogenesis in an In Vitro SystemArticle Published on 2022-01-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 3D electron microscopy modeling acute respiratory syndrome antiviral drugs caused Cell cell membrane cellular compartments change characterization conducted coronavirus cytoplasmic membrane described Endoplasmic reticulum Exocytosis impacted in vitro lipid droplet MERS-CoV Microscopy morphogenesis occurred pandemic Particle performed progeny proliferation Prophylactic public health Replication replication mechanism SARS-CoV SARS-CoV-2 SARS-COV-2 infection scanning electron microscopy susceptible syncytia formation System therapeutic took place Transmission transmission electron microscopy ultrastructural studies understanding Vero-E6 cell Vero-E6 cells Vesicle virus [DOI] 10.3390/v14020201 PMC 바로가기 [Article Type] Article
Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of ConcernCommunication Published on 2021-12-302022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Alpha antibody B.1.1.7 B.1.351 B.1.617.2 changes in Characteristics concern correlated COVID-19 pandemic demonstrated described effective Effectiveness evaluated Evolution exhibited Genetic management P.1 physiological physiological temperature plaque polymerase progeny Rate Replication Replication rate RNA viruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants stability therapeutic thermal thermal stability Transmissibility Vaccine variant variants of concern variants of interest Virological virological study viruses VoC VOCs [DOI] 10.3390/v14010055 PMC 바로가기 [Article Type] Communication
mTOR kinase is a therapeutic target for respiratory syncytial virus and coronavirusesArticle Published on 2021-12-242022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] absence antiviral agent antiviral drugs approach approach approaches cause cellular children coronavirus coronavirus described disease effective effective antiviral treatment Factors function Gene Expression Host Infant Infection Intervention kinase life-threatening Lower respiratory tract Mild Molecular biology mRNA mTOR signaling progeny Protein reduce respiratory respiratory pathogen respiratory syncytial virus respiratory tract infection RSV shown Symptom therapeutic target Transcription upper respiratory tract Vaccine Viral host response viral infection viral infections viral pathogenesis Viral resistance virus while [DOI] 10.1038/s41598-021-03814-7 PMC 바로가기 [Article Type] Article
Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin출현 SARS-COV-2 변이체 : 비교 복제 역학 및 Thapsigargin에 대한 높은 감도Research Article Published on 2021-12-122022-09-10 Journal: Virulence [Category] SARS, 변종, 치료제, [키워드] Alpha Antiviral Beta blocked Co-infection Combination controls COVID-19 pandemic Delta dominant dose effective Effectiveness emergent variants examined exhibited greater highest hpi include Infection infections inhibiting initial Post-infection priming priming dose progeny Replication Replication rate replication synergy RNA SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viruses sensitivity single variant Spectrum spread to susceptible Syncytia synergy thapsigargin variant variants Viral Viral RNA virulent virus viruses were assessed [DOI] 10.1080/21505594.2021.2006960 PMC 바로가기 [Article Type] Research Article
Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model단일 도메인 항체의 비강 전달은 동물 모델에서 SARS-CoV-2 감염의 증상을 개선합니다Research Article Published on 2021-10-142022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration alveolar amplified animal model antibody Behavior block blood stream can not cause caused Cell cells conditions coronavirus COVID-19 COVID-19 patients cryo Cryo-electron microscopy cytokine demonstrated drug drug candidates electron microscopy fusing hamster hamsters host cell host cell membrane human lung organoids immune reaction IMPROVE in vitro infected cell infected cells infective inhibited lead less life-threatening lung Medical conditions membrane Microscopy N-terminal domain nasal nebulizer neutralize neutralized nose occur potency Prevent prevented produced progeny receptor Receptor binding domain reducing Reinfection respiratory risk S protein SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe pneumonia Symptom Symptoms the disease therapeutic drug TMPRSS2 treat treated Treatment typical symptom typical symptoms Vaccine Viral viral membrane virus weight loss while [DOI] 10.1371/journal.ppat.1009542 PMC 바로가기 [Article Type] Research Article
Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion PeptidesArticle Published on 2021-10-102022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] alkaloid alkaloids alteration antiviral action antiviral therapy calcium cholesterol composed Compound concentrations coronavirus COVID-19 decrease demonstrated Effect effective Efficiency fluorescence microscopy fragment fusion fusion peptide greater in vitro indicated inhibit inhibitory investigated knowledge Lipid Mediated membrane membrane fusion MERS-CoV non-toxic Novel coronavirus pandemic peptides Phosphatidylcholine physical piperine plant Prevent progeny reduce SARS-CoV2 scattering shown significant changes in significantly suppress tested Vero Cell Vesicle viral fusion inhibitor [DOI] 10.3390/biomedicines9101434 PMC 바로가기 [Article Type] Article
The urgent need for more basic research on SARS-Cov2 infection and vaccines in assessing potential psychoneurological effects using maternal immune activation (MIA) and other preclinical modeling모성 면역 활성화(MIA) 및 기타 전임상 모델링을 사용하여 잠재적인 정신 신경학적 효과를 평가하기 위한 SARS-Cov2 감염 및 백신에 대한 보다 기초적인 연구가 시급합니다.Review Published on 2021-10-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 변종, [키워드] accumulates aging allergy Autoimmunity Behavior Clinical data during pregnancy Effect Efficacy expression foster General population heterogeneity human ACE2 receptor immune activation immune response immune responses incorporation Infection likelihood Maternal Maternal Immune Activation MIA mutants neurologic obesity pandemic Preclinical Preclinical Testing Pregnancy progeny receptor Research responses SARS-CoV2 Stage supported target tissue TLR Transgenic mouse Vaccine vaccine candidate vaccine candidates Vaccines. variable [DOI] 10.1016/j.bbi.2021.06.009 PMC 바로가기 [Article Type] Review
Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung CellsCommunication Published on 2021-09-262022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 229E acid added affected Antiviral antiviral activity Antiviral compound caused coronavirus Coronaviruses COVID-19 pandemic CPE Cytopathic effect deaths demonstrated disrupting Ebola effective effective antiviral treatment Efficacy epithelial Epstein Barr virus exhibited expression fusion inhibitor ginkgolic acid globe HCoV-229E Herpe HIV HSV-1 Human Human coronavirus in vitro in vivo individual Infection influenza A inhibit inhibited inhibiting lung cell Post-infection progeny Proteins reduced reported SARS-CoV-2 significantly similarity strain Vaccine Viral mutations Viral protein Viral proteins virus production viruses [DOI] 10.3390/ph14100980 PMC 바로가기 [Article Type] Communication
COVID-19 Vaccines for HIV-Infected PatientsHIV에 감염된 환자를위한 COVID-19 백신Review Published on 2021-09-222022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] adaptive AIDS appear can be used clinical trial complementary Complementary DNA COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death defense mechanisms Diagnosis disease entity DNA effective enzyme etiologic agent General population helper T cell helper T cells HIV HIV infection HIV/AIDS HIV/AIDS patients immune defense immune parameter immune systems Immunocompromised immunodeficiency disease implementation include infecting Infection initial lead Limited mechanism microbial molecular test Molecular tests mRNA new virus outcomes Pathogens PCR progeny Protective reverse transcriptase Safe SARS-CoV-2 SARS-CoV-2 vaccines shown susceptibility susceptible T cell T cells transcriptase unique vaccination Vaccine variety Viral Viral RNA virus wake [DOI] 10.3390/v13101890 PMC 바로가기 [Article Type] Review