The UCSC Genome Browser database: 2021 updateUCSC 게놈 브라우저 데이터베이스: 2021년 업데이트AcademicSubjects/SCI00010 Published on 2021-01-082022-09-10 Journal: Nucleic Acids Research [Category] MERS, 유전자 메커니즘, [키워드] added annotation Community coronavirus database display elements ENCODE feature gene annotation gene annotations Genome genome browser Genomics heatmap Improvements include Matched NCBI New outbreak promoter promoters provided RefSeq released required Research RNA the SARS-CoV-2 Trio UCSC Genome Browser VCF files [DOI] 10.1093/nar/gkaa1070 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Hydroxychloroquine Controversies: Clinical Trials, Epistemology, and the Democratization of Science하이드록시클로로퀸 논쟁: 임상 시험, 인식론, 과학의 민주화Article Published on 2020-12-012022-09-11 Journal: Medical anthropology quarterly [Category] SARS, 치료제, [키워드] AIDS AIDS activism center Chloroquine clinical clinical trials complex COVID-19 democratization drugs Effectiveness Epistemology focus Fractions French Hydroxychloroquine Infectious disease knowledge Patient President promoter promoters randomized clinical trial randomized clinical trials randomized clinical trials. RCTs Science trajectory [DOI] 10.1111/maq.12622 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: Triggering a Lethal Fight to Keep Control of the Ten-Eleven Translocase (TET)-Associated DNA Demethylation?Review Published on 2020-11-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accounted activities activity acute respiratory syndrome adjacent sequences affected bimodal binding site cellular children clinical symptom complex Control coronavirus coronavirus 2 correlation COVID-19 deregulation DNA DNA methylation enzyme Factor function Gene Expression high mortality higher risk homeostasis Host hypoxia in vitro In vitro studies inactivation include intestinal Keep lethal liver mortality rate neuronal Patient patients promoters proteasomal Protein regulated Regulation Regulatory respiratory responsible SARS-CoV-2 selective Symptom Symptoms TET TET enzymes TET2 translocase viral invasion virus inactivation women X chromosome Xist [DOI] 10.3390/pathogens9121006 PMC 바로가기 [Article Type] Review
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2SARS-CoV-2의 진입 수용체인 지오텐신 전환 효소 2의 생물정보학적 특성화Research Article Published on 2020-10-282022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 gene ACE2 mRNA age and gender Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 angiotensin-converting enzyme 2 binding site Bioinformatic bioinformatics caused Cell cell type cell types ciliary classical club COVID-19 COVID-19 epidemic duodenum endothelial entry receptor enzyme epithelial epithelial cells expressed expression functions Gene ontology analysis goblet goblet cells Health Organization highest immunohistochemistry include indicated interferon-stimulated response element International IRF8 IRF9 kidney lung Novel coronavirus novel coronavirus SARS-CoV-2 Ontology organ pandemic positive predict promoter promoters Protective public health emergency Regulation Renin renin-angiotensin system respiratory respiratory tract SARS-CoV-2 signal small intestine Stat1 suggested target cell target cells Testis Trachea transcription factor transcriptional regulation Vascular vessel World Health Organization [DOI] 10.1371/journal.pone.0240647 PMC 바로가기 [Article Type] Research Article
Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformansCryptococcus neoformans에서 가져온 쿼럼 센싱 펩타이드에 의해 제어되는 전사 인자의 게놈 연관성을 조정합니다.Research Article Published on 2020-09-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Affect association binding Cell Cell density cell surface receptor cell wall change chromatin immunoprecipitation Control control cell Coordinate Cryptococcus Cryptococcus neoforman Cryptococcus neoformans Deletion eukaryotic expression form function functions fungal fungal pathogens Gene Expression Genes Genetic genomic genomic studies genomic study human body Hypothesis identify Impact infect Macrophage macrophages mating mechanism Meningitis microbe modulate modulating pathogen pathogenic Pathogens peptide predicted promote promoters proximal quorum regulated required reveal secreted surface receptor target transcription factor transcription factors virulence whole-genome [DOI] 10.1371/journal.pgen.1008744 PMC 바로가기 [Article Type] Research Article
The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicansp38/HOG 스트레스 활성화 단백질 키나제 네트워크는 칸디다 알비칸스의 성장과 분열을 연결합니다Research Article Published on 2019-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis basal Candida Candida albican Candida albicans Cell cell cycle cell division cell growth cell proliferation commitment complex conserved Control Critical developmental division environmental cues eukaryotic eukaryotic cell eukaryotic cells G1 Phase G1/S transition Gene Expression Genetic growth homeostasis identify inhibit inhibited kinases knowledge MAPK mutant mutants nexus overlapped pathogenic yeast performed plasticity Point problem promoter promoters Protein protein kinase protein kinases Quantitative Regulation regulatory pathway respond restriction ribosome biogenesis Saccharomyces cerevisiae threshold Transcription transcription factor transcription factors transcriptional regulator transcriptional regulators yeast [DOI] 10.1371/journal.pgen.1008052 PMC 바로가기 [Article Type] Research Article
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C . elegans핵 호르몬 수용체 NHR-86은 C에서 항병원체 반응을 조절한다. 엘레강스Research Article Published on 2019-01-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation adaptive analysis Author bacterial pathogen baseline bind biological function canonical characterized chromatin chromatin immunoprecipitation Control determine Drosophila effector elegan elegans exogenous ligands experiments family function Genetic genetic screen Genome homolog hormone receptor hormone receptors host response Human immune immune activation immunostimulatory induce Infection innate immune activation majority MAPK modulate nuclear pathogen pathway PMK-1 positioned promoter promoters Protective Protein provide Pseudomonas aeruginosa Recognition Regulation required response small molecule target Transcription transcription factor transcription factors transcriptional transcriptional regulator transcriptional response Transcriptome [DOI] 10.1371/journal.pgen.1007935 PMC 바로가기 [Article Type] Research Article
Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network비평형 억제인자 결합 동역학은 SOS 유전자 네트워크 내에서 DNA 손상 용량을 전사 타이밍에 연결합니다Research Article Published on 2018-06-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activity bacterial DNA best binding binding interaction binding kinetics Biochemical pathways cause Cell cellular Concentration Critical defined Degradation disequilibrium DNA binding DNA damage DNA damage repair pathway DNA damaging dose drop Escherichia coli expression Gene Expression Genes kinetic leads LexA low dose mechanism modulate network operator operators pathway Physiology promoter promoters rapid equilibrium assumptions regulate regulated Regulatory respond resulting reveal separated SOS gene SOS pathway SOS response subset the cell the timing These data Transcription transcription factor transcription regulation transcriptional transcriptional repressor Trigger triggers [DOI] 10.1371/journal.pgen.1007405 PMC 바로가기 [Article Type] Research Article
Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거Research Article Published on 2017-04-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed [DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article