Nanoparticle-Based Bivalent Swine Influenza Virus Vaccine Induces Enhanced Immunity and Effective Protection against Drifted H1N1 and H3N2 Viruses in MiceArticle Published on 2022-11-032023-06-24 Journal: Viruses [Category] 신종인플루엔자, [키워드] adjuvant nanoparticle protective immunity swine influenza virus Vaccine [DOI] 10.3390/v14112443 PMC 바로가기
Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in miceArticle Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] Activation Arm cellular COVID-19 disease demonstrated development disease Efficacy hamster humoral IgA immune Immunity immunization induce intramuscular intramuscularly intranasal intranasally Lower respiratory tract lung Lung pathology medical need memory B cell mice mucosal mucosal immune pandemic promote protective immunity public health rapid progress response resulting robust S-2P Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Seroconversion Spike protein systemic immune response the SARS-CoV-2 Transmission unique upper respiratory tract Vaccine vaccine candidate variants viral clearance weight loss while [DOI] 10.1371/journal.pone.0272594 PMC 바로가기
Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19Article Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] anti-Nucleocapsid IgG anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody Antigen booster vaccination cellular cellular immunity Cohort Concentration convalescent COVID-19 detectable domain Endemic humoral IFN-γ IgG immune response Immunity Immunoglobulin Immunosuppressed Immunosuppression immunosuppressive individual liver Liver transplantation membrane nucleocapsid Prevalence protective immunity reactivity Receptor binding domain recipient remained retrieved robust SARS-CoV-2 significantly increased Spike protein stimulated T cell T cell response therapy vaccination [DOI] 10.1371/journal.pone.0276929 PMC 바로가기
A case of COVID-19 reinfection in a hemodialysis patient: the role of antibody in SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: CEN case reports [Category] SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibodies antibody Antibody titer Asymptomatic COVID-19 center Contact coronavirus COVID-19 develop discharged End-stage renal disease evaluate Favipiravir full-length S protein global health Hemodialysis hospital Hospitalized IgG Immunoglobulin Infection initial intensive care Medicine Neutralizing antibodies neutralizing antibody occurred outbreak oxygen Patient protective immunity Protein Reinfection renal Respiratory failure risk S1 subunit SARS-CoV-2 SARS-COV-2 infection Seroconversion Severe acute respiratory syndrome coronavirus 2 antibodies. spike steroid treatment symptomatic Symptoms transferred [DOI] 10.1007/s13730-022-00697-z PMC 바로가기
Comparison of SARS-CoV-2 spike antibody quantitative titer reporting using the World Health Organization International Standard Units by four commercial assaysArticle Published on 2022-11-012022-11-15 Journal: Journal of Clinical Virology [Category] SARS, 진단, [키워드] Abbott Accuracy antibodies antibody Antibody Response Antibody titer Architect BAU BNT162b2 ChAdOx1-S collected comparable correlation COVID-19 DiaSorin effective Elecsy elicited Genscript greater IgG immune response Immunoglobulin indicated individual International LIAISON Moderna mRNA-1273 naïve Neutralizing antibody titer Oxford-AstraZeneca Pfizer/BioNTech plasma protective immunity Quantitative Quantitative serological assays ranged regression analysis response Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination sensitivity seroconverted serological serological response significantly higher specificity Standard tested the WHO unit Vaccine Vaccines virus neutralization assays WHO WHO International Standard World Health Organization [DOI] 10.1016/j.jcv.2022.105292 PMC 바로가기
Differential avidity determination of IgG directed towards the receptor-binding domain (RBD) of SARS-CoV-2 wild-type and its variants in one assay: Rational tool for the assessment of protective immunityArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome avidity binding coronavirus IgG IgG RBD Infection LINE mandatory marker mRNA much lower Omicron variant Protective protective immunity RBD reached Receptor-binding domain recom Line SARS-CoV-2 IgG. SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection serology Spike protein the receptor-binding domain vaccination variant wild-type WT SARS-CoV-2 [DOI] 10.1002/jmv.28006 PMC 바로가기
The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemicArticle Published on 2022-11-012022-11-16 Journal: Immunology [Category] SARS, 변종, [키워드] Asymptomatic breadth cellular Clinical severity COVID-19 COVID-19 pandemic Critical Cross-immunity cytokine Cytokine storm detrimental disease disease severity effort events Evidence feature highlighting immune response Immunopathogenesis Infection Innate immunity pathogen pathogenic processes Protective protective immunity protective role provided public health reducing resulting T-cell immunity the SARS-CoV-2 therapeutic approaches tissue injury Vaccine Viral variants [DOI] 10.1111/imm.13564 PMC 바로가기
Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2Article Published on 2022-10-122022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated T cell antibodies antibody Antibody Response booster booster dose booster vaccination CD137 CD69 CD8 T cell Cellular immune response ChAdOx1-S conducted decrease dose expressing expression Frequency humoral IFN-γ immune response immunosuppressive increase in indicated Infection Injections lack longitudinal analysis memory monocyte mRNA mRNA vaccine myeloid cell omicron participant PD-L1 peptides phenotype producing protective immunity reactive reduced SARS-CoV-2 SARS-CoV-2-specific T cell T cell T cell response T cells the spike protein TNF-α upregulation vaccination Vaccinations Vaccine variant vector vaccine virus-specific T cell [DOI] 10.3389/fimmu.2022.1012526 PMC 바로가기
Comparing the B and T cell-mediated immune responses in patients with type 2 diabetes receiving mRNA or inactivated COVID-19 vaccinesArticle Published on 2022-10-112022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome adverse outcome Alpha Anti-RBD IgG BNT162b2 CD4 CD8 cell-mediated immune response cellular Clinical outcome comparable CoronaVac coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 vaccine COVID-19 vaccines diabete dose Effectiveness evaluated first dose healthy individual humoral immune response IgG antibody immune dysfunction Immunological memory immunological memory response Immunological response inactivated Infection influence initial memory mRNA neutralizing antibody neutralizing capacity of BNT162b2 Part Patient platform potential mechanism protective immunity RBD receiving Receptor binding domain reduction in resulting SARS-CoV2 second dose sera susceptibility T cell response T cells T2D Th1 titre Type type 2 diabete type 2 diabetes vaccination vaccinee Vaccines [DOI] 10.3389/fimmu.2022.1018393 PMC 바로가기
Longitudinal cellular and humoral immune responses after triple BNT162b2 and fourth full-dose mRNA-1273 vaccination in haemodialysis patientsArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] ACE2 binding addition administration analysed anti-RBD B.1 binding BNT162b2 boost immunity cellular Control controls COVID-19 COVID-19 vaccination Decline declining Delta detectable dialysis dose doses group Haemodialysis Haemodialysis patient humoral humoral immune response Humoral immunity IgG IgG response immune immune evasion immune protection immunoassays Immunocompromised individual individuals information interferon γ knowledge longitudinal longitudinal response maintain mixed mRNA vaccination mRNA mRNA vaccination mRNA-1273 mucosal omicron Omicron variant of concern Patient patients Prevent protective immunity RBD reached regimen remained respond poorly restored SARS-CoV-2 vaccination SARS-CoV-2 variant second vaccination severe COVID-19 significantly increased spike subsequent Support T-cell Response tested the receptor-binding domain vaccination Vaccine variant variants of concern [DOI] 10.3389/fimmu.2022.1004045 PMC 바로가기