The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegansGATA 전사 인자 egl-27은 꼬마선충의 스트레스 저항성을 촉진하여 노화를 지연시킵니다Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated activated Affect age aging aging process alteration animals Author Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans conserved daf-16 Delay Effect elegan expression Factor Factors found FoxO GATA GATA transcription factor Gene Genes heat stress identify IGF-1 impair IMPROVE increase inhibited insulin Intersection involved limit Longevity molecular mechanism molecular mechanisms mutant overexpression oxidative stress pathway Pathways promote Promoting PROTECT protective response protective responses receptor reduced required resistance response Signaling significantly Stress stress response stress responses suppresse survival target transcription factor wild-type worm worms [DOI] 10.1371/journal.pgen.1003108 PMC 바로가기 [Article Type] Research Article
Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patientsResearch Published on 2010-11-042022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] animal model Anti-RBD antibody Antibody Response antigenicity approach assays characterized diagnostic ELISA Follow-up found Human immunogenic included induce Neutralizing activity Neutralizing antibodies neutralizing antibody potent protective response Protein purified RBD RBD of SARS-CoV RBD-specific antibody recovered patient Result robust S protein SARS patient SARS-CoV SARS-CoV spike protein serum sample the antibody response the RBD the receptor-binding domain Vaccine were measured [DOI] 10.1186/1743-422X-7-299 PMC 바로가기 [Article Type] Research