Adverse events following COVID-19 vaccination: A systematic review and meta-analysisResearch article Published on 2022-08-012022-10-05 Journal: International immunopharmacology [Category] 비임상, 임상, [키워드] 95% CI Adverse adverse event adverse events Adverse reaction approved benefit calculated clinical trial control group COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines database DNA DNA vaccine Efficacy Efficacy and safety event greater immunization Inactivated vaccine ISI Local Meta-analysis mRNA mRNA vaccine Occurrence protein subunit vaccine raised Result risk Safety SARS-CoV-2 searched systematic review systemic adverse reaction systemic and local vaccination Vaccine Vaccines WHO [DOI] 10.1016/j.intimp.2022.108906 [Article Type] Research article
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2SARS-CoV-2에 대한 보호 프로토타입-베타 및 델타-오미크론 키메라 RBD-이량체 백신Article Published on 2022-06-232022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] approach Beta breakthrough infections chimeric circulating COVID19 COVID19 vaccine Delta delta variant develop dimeric domain elicited forms immunogen structure immunogens Infection macaques mice multivalent vaccine neutralization omicron Omicron variant pandemic prevalent protein subunit vaccine prototype RBD RBD-dimer Receptor-binding domain SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera Subunit vaccine supported Vaccine vaccine protection variant variant of concern variants VoC ZF2001 [DOI] 10.1016/j.cell.2022.04.029 PMC 바로가기 [Article Type] Article
Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters프로테오솜 보조제가 첨가된 SARS-CoV-2 스파이크 단백질 기반 백신을 사용한 비강내 면역은 마우스와 햄스터에서 면역원성과 효능이 있습니다.Article Published on 2022-06-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Antigen B.1.351 B.1.617.2 Beta binding Blood body weight Body weight loss cellular Delta disease evaluated Formulation hamster help IgA titers IgG immune responses immunization immunogenic intranasal Lungs mice mucosal mucosal surface Neutralizing activity offer pandemic persistence prefusion Prevent profile protective immune response Protein protein subunit vaccine reduce reducing reference strain resistin robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 vaccine serum antibodies serum antibody spike Spike protein Subunit vaccine the SARS-CoV-2 Vaccine variants variants of concern Viral viral entry Viral load viral spike protein weight loss [DOI] 10.1038/s41598-022-13819-5 PMC 바로가기 [Article Type] Article
Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine범사르베코바이러스 수지상세포 표적화 백신의 설계, 면역원성 및 효능Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Antigen antigens antiviral efficacy B-cell epitope B-cell epitopes BNT162b2 CD40 conserved Coronaviruses COVID-19 cross-neutralizing antibodies cross-neutralizing antibody cross-reactive demonstrated dendritic cells Efficacy elicited ENhance Epitopes framework functional hACE2 homologous immunization immunogenic immunogenicity in vitro initiative K18-hACE2 transgenic mice Medicine MERS mice mRNA BNT162b2 vaccine Mutation Neutralizing antibodies nucleocapsid potency Pre-clinical model protein subunit vaccine recall Sarbecoviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S spike Subunit vaccine supported surface receptor survival T-cell Response T-cell responses Vaccine variants of concern Viral viral control VoC VOCs [DOI] 10.1016/j.ebiom.2022.104062 PMC 바로가기 [Article Type] Article
Effective protection of ZF2001 against the SARS-CoV-2 Delta variant in lethal K18-hACE2 mice치명적인 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 ZF2001의 효과적인 보호Article Published on 2022-05-202022-09-11 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, [키워드] aluminum approval China Delta delta variant Efficacy Epidemics hACE2 improvement K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice Lung histopathology mechanism neutralizing antibody omicron Prevent protection Protective protective effect protein subunit vaccine reduced required Research research and development SARS-CoV-2 SARS-CoV-2 Delta variant severe cases severe pneumonia Subunit vaccine survival rates the SARS-CoV-2 Vaccine Vaccine design variant virus was used ZF2001 ZF2001. [DOI] 10.1186/s12985-022-01818-x PMC 바로가기 [Article Type] Article
Low-Dose SARS-CoV-2 S-Trimer with an Emulsion Adjuvant Induced Th1-Biased Protective Immunity저용량 SARS-CoV-2 S-삼량체(에멀젼 보조제 유도 Th1 편향 보호 면역 포함)Article Published on 2022-04-282022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 binding addition adjuvant alum aluminum aluminum hydroxide Antibody Response Antigen Antisera B cell B cells Beta binding affinity Cellular immune response clinical testing comparable Complete COVID-19 pandemic Delta demonstrated different dose different doses effective Efficacy Emulsion ENhance evaluated exhibit feasible follicular Germinal center herd immunity humoral immune response hydroxide immune responses Immunity immunogenicity induce induced Infection Lineage live SARS-CoV-2 low dose lower dose mass vaccination mice Mutation Neutralizing antibodies neutralizing antibody prefusion Prevent produced Protective protein subunit vaccine rodent rodents Safe SARS-CoV-2 Subunit vaccine Support sustained SWE T-cell T-cell responses T-cells Tfh the antibody response These data trimer utility vaccination Vaccinations Vaccine variant variants Viral viral infection viral spread were assessed [DOI] 10.3390/ijms23094902 PMC 바로가기 [Article Type] Article
Immunogenicity and protective efficacy of a recombinant protein subunit vaccine and an inactivated vaccine against SARS-CoV-2 variants in non-human primates비인간 영장류에서 SARS-CoV-2 변이체에 대한 재조합 단백질 소단위 백신 및 불활성화 백신의 면역원성 및 보호 효능Article Published on 2022-03-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ADCC Alpha antibody Antibody titers antibody-dependent cellular cytotoxicity B.1.351 Beta Beta variant binding Breakthrough infection circulating variant COVID-19 vaccine cytokine declined Delta demonstrated domain downregulated effective Efficacy followed by immune memory immunized immunogenicity inactivated Inactivated vaccine increase in Infection Inflammatory cytokine involved lung tissue lung tissues Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer non-human primate omicron Omicron variants Other pathological changes post vaccination Protective protective effect protective mechanism Protein subunit protein subunit vaccine prototype provided RBD Receptor-binding domain reduction respiratory respiratory tracts rhesus macaque rhesus macaques SARS-CoV-2 variant sera significantly Strains Vaccine Vaccines variant Viral Viral load virus VOCs was reduced [DOI] 10.1038/s41392-022-00926-y PMC 바로가기 [Article Type] Article
A protein subunit vaccine booster following two doses of inactivated SARS-CoV-2 vaccine provides high neutralisation of SARS-CoV-2 and its variants in mice비활성화된 SARS-CoV-2 백신 2회 투여 후 단백질 소단위 백신 부스터는 마우스에서 SARS-CoV-2 및 그 변이체의 높은 중화를 제공합니다Article Published on 2022-03-012022-09-11 Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 진단, [키워드] booster dose inactivated mice neutralisation protein subunit vaccine provide SARS-CoV-2 SARS-CoV-2 vaccine variant [DOI] 10.1016/S2666-5247(21)00331-1 PMC 바로가기 [Article Type] Article
Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies불활성화 백신의 동종 또는 이종 부스터는 중화 항체로부터 SARS-CoV-2 오미크론 변이체 탈출을 감소시킵니다.Coronaviruses Published on 2022-02-042022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accumulated addition antibodies Antibody titer B.1.1.529 BBIBP-CorV booster booster vaccination convalescent dose eight epitope Epitopes Heterologous homologous homologous or heterologous identified variant inactivated Inactivated vaccine individual less mAb mAbs monoclonal antibodies monoclonal antibody neutralization neutralization titer neutralization titers Neutralizing neutralizing antibody Neutralizing antibody titer NTD omicron Omicron variant protein subunit vaccine pseudovirus raising RBD reduce reduction SARS-CoV-2 SARS-CoV-2 variants sera Seven significantly increased spike mutations Subunit vaccine tested the vaccine therapeutic therapeutic antibodies transmission of SARS-CoV-2 urgency Vaccine variant Viral viral variant VOCs ZF2001 [DOI] 10.1080/22221751.2022.2030200 PMC 바로가기 [Article Type] Coronaviruses