Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in miceArticle Published on 2022-11-012022-11-15 Journal: Inflammation research : official journal of the Eu [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alleviate Analysis Anti-inflammatory anti-inflammatory property anti-inflammatory response ARDS CFZ Clofazimine coronavirus disease COVID-19 Critical decrease disease Diseases distress down-regulate histological change hyperimmune response IL-1β immune IMPROVE increasingly Infectious disease Inflammatory information inhibit involved lipopolysaccharide LPS lung Lung injury Macrophage macrophages mechanism mice Molecular biology pathway pharmacological mechanism potential molecular profile proliferation protective effect Protein protein expression Proteomic analysis proteomics Pulmonary edema Quantitative Signal transduction Signaling significantly survival rate syndrome therapeutic strategy TNF-α [DOI] 10.1007/s00011-022-01623-w PMC 바로가기
Proteomic analysis of neutrophils from patients with COVID-19Article Published on 2022-10-012022-11-16 Journal: British Journal of Haematology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] neutrophil patients with COVID-19 Proteomic analysis [DOI] 10.1111/bjh.18347 PMC 바로가기
Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19심장대사 바이오마커의 단백질체 분석 및 COVID-19로 입원한 환자의 심각한 결과 예측 모델링Article Published on 2022-07-212022-09-11 Journal: Cardiovascular Diabetology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerate ACE2 ADAMTS13 Admission Analysis association Biomarker Biomarkers cardiometabolic Cardiometabolic biomarkers cardiometabolic disease Care circulating Clinical data collected Comorbidity COVID-19 COVID-19 severity death First wave heterogeneity high-risk patient High-risk patients higher risk identify IL-1ra IL6 implicated intensive care intensive care unit likelihood lower risk outcome outcomes pandemic Patient patients patients hospitalized performed plasma sample plasma samples predict Predictive Predictive model Predictive modeling predictive models Protein proteomic Proteomic analysis proteomics Recognition Risk factors Seven severe COVID-19 severity severity of COVID-19 shown susceptible Symptom the disease Treatment VEGFD with COVID-19 [DOI] 10.1186/s12933-022-01569-7 PMC 바로가기 [Article Type] Article
Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention운동 유도 미오카인은 기관지 상피 세포에서 ACE2 수준을 하향 조절합니다: SARS-CoV-2 예방에 대한 의미Article Published on 2022-07-202022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] A549 ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models applied approach approaches Bronchial epithelium cancer cell line Cell Cell culture cell culture study cell line centrifugation condition conditioned media controls COVID-19 pandemic culture system cytokine Cytokines death rate decrease demonstrated downregulate downregulation Effect ELISA ELISAs enzyme enzyme-linked immunosorbent assay epidemiological studies epithelial exercise exposure to expression form generate highlighting human lung immortalized lung cancer marker mass spectroscopy media mitigate modulating mRNA myokine pandemic Part PCR physical activity potential therapeutic target potential therapeutic targets priming protective effect protein level proteomic Proteomic analysis public health pulse Quantitative quantitative real-time PCR Quantitative RT-PCR receptor reduction remained replicated respiratory viruses rigor risk of infection RT-PCR SARS-CoV-2 sensitivity Serine shown Skeletal muscle skeletal muscles stimulated the SARS-CoV-2 TMPRSS2 TMPRSS2 protein transmembrane serine protease transmembrane serine protease 2 treated Treatment vaccination Vaccinations virulent virus was performed while [DOI] 10.1371/journal.pone.0271303 PMC 바로가기 [Article Type] Article
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes게놈 전반에 걸친 분석을 통해 SARS-CoV-2 바이러스 유전자 Orf9c가 인간 다능성 줄기 세포 유래 심근세포에 미치는 해로운 영향을 보여줍니다Article Published on 2022-03-082022-09-11 Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated analyses Analysis Apoptosis apoptotic approved ATP ATP synthesis cardiac dysfunction cardiac injury cardiomyocyte caused Cell cellular characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined detrimental detrimental effect detrimental effects disease down-regulated drug Drug administration dysfunction electrical ENCODE expression Factor Factors food functional Genes Genome heart disease heart muscle human pluripotent stem cell Impact Inflammation Injury Ivermectin manifestation Manifestations meclizine meclizine. molecular mechanism molecular mechanisms Orf9c overexpression Pathways Protein Proteins Proteomic analysis reduced respiratory restored SARS-CoV-2 SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly stem cell Therapeutic approach Transcriptomic analyses transcriptomic analysis U.S. Food and Drug Administration up-regulated [DOI] 10.1016/j.stemcr.2022.01.014 PMC 바로가기 [Article Type] Article
Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19Research article Published on 2022-02-232022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] adaptive immune system circulating neutrophil cleavage cleaved clotting coagulation factor COVID-19 expressed expression Factor factor V form hospitalized patient identify immunofluorescence microscopy immunology in vitro Increased inhibitor leukocyte leukocytes liver Lung disease lymphopenia Microbiology Monocytes mononuclear cells mRNA Neutrophils omics Peripheral blood proliferation Proteomic analysis reduce RNAseq scRNAseq severe COVID-19 severe disease suppress T regulatory cell T-cell thrombin transcriptomics Whole blood with COVID-19 [DOI] 10.1016/j.isci.2022.103971 [Article Type] Research article
Identification of mRNA 5′ cap-associated proteins in the human malaria parasite Plasmodium falciparumarticle Published on 2022-01-312024-09-01 Journal: Molecular and Biochemical Parasitology [Category] 말라리아, [키워드] Cap-binding protein eIF4E malaria Plasmodium falciparum Proteomic analysis [Article Type] article
Targeted Detection of SARS-CoV-2 Nucleocapsid Sequence Variants by Mass Spectrometric Analysis of Tryptic Peptides트립신 펩티드의 질량 분광 분석에 의한 SARS-CoV-2 뉴클레오캡시드 서열 변이체의 표적 검출Article Published on 2022-01-072022-09-11 Journal: Journal of Proteome Research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid Analysis antigen detection approach approaches Chain Reaction Coronavirus-2 COVID-19 COVID-19 case detect detection expected flexibility gene encoding highlight immunoassay Liquid chromatography mass mass spectrometry methodology minor Modification nasopharyngeal swabs nucleocapsid nucleocapsid protein nucleotide peptide prevalent Protein proteomic Proteomic analysis qRT-PCR Quantitative quantitative reverse transcription-polymerase chain reaction respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus single amino acid protein variants Single nucleotide polymorphism single nucleotide polymorphisms Spread Tandem mass spectrometry target the SARS-CoV-2 the viral nucleocapsid Vaccine variant variants variants of SARS-CoV-2 Viral viral nucleocapsid protein Viral variants virus Whole genome sequencing [DOI] 10.1021/acs.jproteome.1c00613 PMC 바로가기 [Article Type] Article
Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway AxisSARS-CoV-2 감염 후 심혈관 위험은 IL18/IL18R1/HIF-1 신호 경로 축에 의해 매개됩니다Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] activate activated Activation Algorithm Analysis Aneurysm aneurysms Atherosclerosis axis cardiovascular cardiovascular risk Cell cell types changes in characterized choice Compound COVID-19 COVID-19 infection detect Epigenetic expected functional gene co-expression network HIF-1 HIF-1 signaling pathway HIF1a hypoxia identify IL-18 IL18 IL18R1 Infection Inference Intercellular communication interleukin locus Macrophage macrophages MAP2K1 mechanism Mediated MEK inhibitor Methylation NF-κB nucleus objective pathway Pathways PBMC phenotype phenotypic Potential promote promoted Proteins Proteomic analysis Regulation Regulatory Regulon Result SARS-CoV-2 SARS-COV-2 infection scRNA-seq Signaling signaling pathway smooth muscle therapeutic compound therapeutic target Treatment type I interferon type I interferon pathway vascular smooth muscle vascular smooth muscle cells VIPER was used WGCNA with COVID-19 [DOI] 10.3389/fimmu.2021.780804 PMC 바로가기 [Article Type] Immunology
Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial InflammationSARS-CoV-2–관련 심근 염증과 보체 및 MAPK 활성화의 연관성Research Published on 2021-12-152022-09-10 Journal: JAMA Cardiology [Category] MERS, SARS, 유전자 메커니즘, [키워드] abundance age Analysis assessment biopsies C1q capture capture sequencing cardiac Cardiomyopathy cascade case sery CD163 center Characteristics characterized clade Cohort cohort of patients collected complement Complement cascade component confirmation cysteine Endomyocardial biopsy Ethnicity Exome exploratory exposure Factor finding Future Germany highest histologic Hospitalized immune pathway immune signature Immune-mediated implication Importance individual Infection Inflammatory inflammatory condition inflammatory conditions inhibitor Injury kinases lymphocyte Lymphocyte count lymphocyte counts Macrophage macrophages male MAPK mass mass spectrometry Maximilian measure median age mitogen mitogen-activated protein kinase Munich Myocardial inflammation myocardial injury myocarditis objective participant Participants pathway Pathways Patient patients with SARS-CoV-2 phenotype Point Protein protein kinase protein kinases proteinase Proteins proteomic Proteomic analysis reduce Referral Relevance Result RNA SARS-COV-2 infection Sequencing Serine setting signaling cascade similarities specimen specimens subunit the median threonine tissue transcript transcriptomic transcriptomic analysis Treatment strategies treatment strategy Tübingen university upregulated upregulation Viral viral myocarditis were measured [DOI] 10.1001/jamacardio.2021.5133 PMC 바로가기 [Article Type] Research