The role of lipoprotein(a) in coronavirus disease 2019 (COVID-19) with relation to development of severe acute kidney injury중증 급성 신장 손상의 발병과 관련하여 2019년 코로나바이러스(COVID-19)에서 지단백질(a)의 역할Observational Study Published on 2022-04-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] acute kidney failure Acute kidney injury ADAMTS13 Admission adverse outcome adverse outcomes Biomarkers Coagulopathy Concentration controls coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 illness COVID-19 patient COVID-19 patients creatinine defined disease disease severity elevations fibrinogen IL-6 Inflammation interleukin kidney Kidney failure lipoprotein Lipoprotein(a) observational study outcome Pathogenesis patients with COVID-19 positively correlated prospective observational study prothrombotic serum severity severity of COVID-19 sick significantly thrombosis were measured [DOI] 10.1007/s11239-021-02597-y PMC 바로가기 [Article Type] Observational Study
Treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT)백신 유발 면역 혈전성 혈소판 감소증(VITT)의 치료Review Published on 2022-04-012022-09-12 Journal: Seminars in hematology [Category] MERS, 진단, [키워드] Adenovirus antibodies antibody anticoagulation Atypical ChAdOx1 nCoV-19 characterized Concentration coronavirus disease Corticosteroids COVID-19 disorder Disseminated intravascular coagulation ENhance Frequency heparin heparin-induced thrombocytopenia High-dose High-dose immune globulin (IVIG) immune in vitro inhibit inhibited intravenous Long Long VITT much higher Patient pharmacological plasma platelet activation prothrombotic recipient resulting Therapeutic plasma exchange Therapeutic plasma exchange (TPE) thrombosis thrombotic thrombotic complication Treatment Vaccine Vaccine-induced immune thrombotic thrombocytopenia (VITT). [DOI] 10.1053/j.seminhematol.2022.03.002 PMC 바로가기 [Article Type] Review
COVID-19: an opportunity of systematic integration for Chagas disease. Example of a community-based approach within the Bolivian population in BarcelonaCOVID-19: 샤가스병에 대한 체계적인 통합의 기회. 바르셀로나의 볼리비아 인구 내 커뮤니티 기반 접근 방식의 예Article Published on 2022-03-282022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 치료기술, [키워드] Affect Americas approach average Barcelona benefit Bolivia Bolivian Cardiomyopathy Care cause Chagas disease chronic infection Co-infection Coinfection Community Community-based approach components conducted COVID-19 COVID-19 pandemic diagnosed diagnostic test epidemiological Europe healthcare increase Infection Latin America Neglected opportunity Opportunity of systematic integration. overlapping Patient Prevalence prothrombotic Rapid diagnostic test Research resources risk sensitivity severe COVID-19 shown the patient the SARS-CoV-2 tropical disease [DOI] 10.1186/s12879-022-07305-6 PMC 바로가기 [Article Type] Article
Multiphysics and multiscale modeling of microthrombosis in COVID-19Research Article Published on 2022-03-072022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] activities Blood Blood coagulation blood flow blood sample Cell cell cluster circulating cell clinical evidence Cluster Coagulation coagulation factor component contribute Coronavirus disease 2019 COVID-19 Endothelial cell evaluated exacerbate Factor identify in vitro Inflammatory response leukocyte mechanism microthrombi microthrombus offer Patient patients with COVID-19 powerful tool Predictive progression prothrombotic provide Quantitative recruitment reported SARS-CoV-2 target the disease Therapeutic approach thrombosis thrombus formation Transport treating COVID-19 Treatment WBC [DOI] 10.1371/journal.pcbi.1009892 PMC 바로가기 [Article Type] Research Article
A phase I, first-in-human, randomized dose-escalation study of anti-activated factor XII monoclonal antibody garadacimab항 활성화 인자 XII 단일 클론 항체 garadacimab의 I 상, 최초 인간, 무작위 용량 증량 연구Clinical Trial Published on 2022-03-012022-09-12 Journal: Clinical and translational science [Category] MERS, 임상, 진단, [키워드] activated activities Analysis antibodies blood sample clinical development Coagulation Cohort cohorts collected Contact coronavirus disease COVID-19 deaths demonstrated dose dose-dependent dose-dependent manner dose-escalation Effect eight Factor healthy healthy volunteers increase in increases in inhibit intravenous male monoclonal antibody MOST pathway Phase I Placebo plasma plasma concentration positive proinflammatory Prothrombin time prothrombotic Randomized reported single-center Support TEAE TEAEs tested Tolerability treatment-emergent adverse event Volunteer volunteers [DOI] 10.1111/cts.13180 PMC 바로가기 [Article Type] Clinical Trial
Emerging complications of COVID-19 in a subset of Indian population: a pathological review with clinico-radiological case scenariosReview Published on 2022-02-152022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] ACE-2 Activation acute respiratory syndrome article Body caused Combination complications of COVID-19 component coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 pandemic Cytokine storm deaths downregulation Effect expressed ground glass opacities help imaging increased vascular permeability India Inflammation inflammatory cell interlobular septal thickening manifestation Manifestations multisystemic organ pandemic Pathogenesis pathogenesis of COVID-19 pathophysiology pro-inflammatory prothrombotic reported SARS-CoV-2 second wave subset Systemic complications of COVID-19 thrombosis Vascular viral invasion World Health Organization Wuhan, China [DOI] 10.1186/s43055-021-00680-1 PMC 바로가기 [Article Type] Review
An In Vivo Observational Histological Study of Peripheral Arterial Damage in Patients with Acute Limb Ischemia in SARS-CoV-2 InfectionArticle Published on 2022-02-142022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] active smokers Acute limb ischemia Analysis analyzed arterial Arterial hypertension CD45 CD68 change damage Diabetes Mellitus endothelial Endothelial dysfunction events Evidence histologic histological histopathological immunohistochemistry in vivo Inflammation intraarterial investigated Ischemia lack limb mechanism obese Patient patients patients with COVID-19 performed peripheral prothrombotic Reactions reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients skeletal muscles structures suffered Thrombus thrombus formation tissue [DOI] 10.3390/diagnostics12020488 PMC 바로가기 [Article Type] Article
COVID-19, Vaccines, and Thrombotic Events: A Narrative ReviewReview Published on 2022-02-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activating adenovirus-based affected age antibody cardiovascular complications caused Cerebral venous thrombosis chronic cardiovascular Clinical data coding coronavirus coronavirus disease counseling country COVID-19 COVID-19 vaccination epidemiological fertile groups helping hypothese immune Inflammatory mediators narrative offer pandemic Patient platelet factor-4 Platelets potential risk Practitioner promote prothrombotic regulatory agency review risk SARS-CoV-2 Spike proteins subject syndrome the spike protein Thromboembolic events thrombosis thrombotic Thrombotic complications thrombotic event Thrombotic events thrombotic thrombocytopenia syndrome Vaccine vaccine-induced thrombotic thrombocytopenia Vaccines venous women [DOI] 10.3390/jcm11040948 PMC 바로가기 [Article Type] Review
Severe Acute Respiratory Syndrome Coronavirus-2 Pneumonia Presenting Concomitantly With Purpura Fulminans: A Case ReportInfectious Disease Published on 2022-01-132022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute infectious purpura fulminans acute respiratory syndrome association Central nervous system coronavirus disease (COVID-19) Coronavirus-2 covid and purpura fulminans COVID-19 Critically ill Critically ill patient described endothelial damage explicit Hemorrhagic Infarction Inflammation intensive care kidneys life-threatening Lungs multiple organs Novel coronavirus patient with COVID-19 prothrombotic pulmonary critical care purpura report respiratory SARS-CoV-2 Sepsis syndrome thrombosis triggered while with COVID-19 [DOI] 10.7759/cureus.21188 PMC 바로가기 [Article Type] Infectious Disease
C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19C5a 및 C5aR1은 aHUS에서 COVID-19에 이르는 임상 기관에서 미세혈관 혈소판 응집의 주요 동인입니다Article Published on 2022-01-082022-09-11 Journal: Blood advances [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome added aggregation Alternative pathway antithrombogenic Atypical Bacterial infection Bacterial infections binding blockade C5a C5aR1 C5b-9 caused CCX168 Cell chronic inflammatory diseases clinical entity clinical implications Comorbidities Comorbidity complement complement system coronavirus COVID-19 Critical demonstrated develop driver dysfunction dysregulation Effect endothelial endothelial cells Endothelial dysfunction Endothelium Ex vivo Exocytosis Genetic hemolytic uremic syndrome highlight human serum Hyperactivation Infection Inflammatory diseases Microvascular thrombosis normal human serum P-selectin pathogenic mechanisms Patient patients treated Platelet platelet adhesion prothrombotic RalA rare disease Registered selectin serum severe acute respiratory syndrome Coronavirus severe COVID-19 severely ill patients suffered thrombosis Thrombus thrombus formation translate Trial triggered uremic syndrome viral infections von Willebrand factor [DOI] 10.1182/bloodadvances.2021005246 PMC 바로가기 [Article Type] Article