public health threat – Page 2 – Communicable Diseases Research

Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

SARS-CoV-2 변이체에 대한 니르마트렐비르의 시험관내 효능에 대한 구조적 기초

Article

Published on 2022-06-012022-09-11
Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] Alpha B.1.1.529 B.1.1.7 B.1.351 Beta biochemical catalytic activity catalytically cells comparable COVID-19 pandemic crystal structure Delta Efficacy enzymatic assay enzyme evaluated Frequency Gamma in vitro in vitro data inhibitor Ki Lambda M pro M(pro) maintain molecular basis mutant Mutation Nirmatrelvir observation omicron Omicron variant P.1 Paxlovid PF-07321332 plasma concentration plasma concentrations potency prevalent protease Protease inhibitor provided public health threat required Ritonavir SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Tablet tablets the SARS-CoV-2 variant variants variants of concern variants of interest variants of SARS-CoV-2 VoC VOCs VOIs Washington wildtype
[DOI] 10.1016/j.jbc.2022.101972 PMC 바로가기 [Article Type] Article

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir

SARS-CoV-2 변이체의 주요 프로테아제 돌연변이체는 여전히 니르마트렐비르에 감수성입니다

Article

Published on 2022-04-152022-09-11
Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 변종, 치료제,

Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

COVID-19의 기관 흡인물에서 BromAc의 생체 외 점액 용해 및 항염 활성

Article

Published on 2022-04-012022-09-12
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), MERS, SARS, 신약개발, 임상, 진단, 치료제,

[키워드] Acetylcysteine anti-inflammatory activity anti-inflammatory effect BromAc caused chemokine collected Combination Concentration COVID-19 COVID-19 patient COVID-19 patients Critically ill CXCL8 Cytokine analysis Cytokine storm dose drug evaluated Ex vivo G-CSF IL-10 IL-13 IL-5 IL-6 IL-9 IP-10 lethal disease MCP-1 mechanical ventilation MIP-1b mucolysis mucolytic Mucolytic therapy NAC pandemic pharmacological treatment public health threat reducing reduction reduction in regulatory cytokine Respiratory disease robust SARS-CoV-2 sputum therapeutic options tracheal tracheal aspirate treat was performed
[DOI] 10.1016/j.biopha.2022.112753 PMC 바로가기 [Article Type] Article

Defining the risk of SARS-CoV-2 variants on immune protection

Reviews

Published on 2022-03-312022-10-05
Journal: Nature [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제,

Transmissibility and pathogenicity of SARS-CoV-2 variants in animal models

동물 모델에서 SARS-CoV-2 변이체의 전염성 및 병원성

Review

Published on 2022-03-012022-09-11
Journal: Journal of microbiology (Seoul, Korea) [Category] SARS, 변종, 유전자 메커니즘,

The Importance of Prisons in Achieving Hepatitis C Elimination: Insights from the Australian Experience

C형 간염 퇴치를 위한 교도소의 중요성: 호주 경험에서 얻은 통찰력

Article

Published on 2022-02-282022-09-11
Journal: Viruses [Category] 치료제,

How to accelerate the supply of vaccines to all populations worldwide? Part II: Initial industry lessons learned and detailed technical reflections leveraging the COVID-19 situation

전 세계 모든 인구에 대한 백신 공급을 가속화하는 방법은 무엇입니까? 2부: COVID-19 상황을 활용한 초기 업계 교훈 및 상세한 기술적 반성

Review

Published on 2022-02-232022-09-11
Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 신약개발,

Are there differences between COVID-19 and non-COVID-19 inpatient pressure injuries? Experiences in Internal Medicine Units

Research Article

Published on 2022-02-172022-10-28
Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS,

A Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle

푸린을 표적으로 하는 실행 가능한 대안 전략은 SARS-CoV-2 감염 주기를 방해합니다

Research Article

Published on 2022-02-092022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 Activation addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody Response applicability approach binding blockade Cell cellular entry chain cleavage competing coronavirus COVID-19 Critical cycle described disease pathology DNA domain effective Efficacy epitope flexible linker furin Health Hospitalization Host host cell host cells host protease human lung cell human lung cells IgG1 Immunological memory in viral independent Infection infection cycle infections interfere lung cells membrane fusion Mortality occur overcome peptide plug processing producing protease Proteases proteolytic activation Proteolytic processing public health threat remained remains uncertain residue RNA SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viral particles scenario secretory pathway solution spike glycoprotein Spike protein Strategy subsequent targeted therapy targeting the spike protein Transmission Vaccine Viral viral entry Viral transmission virus virus-producing cell virus-producing cells viruses
[DOI] 10.1128/spectrum.02364-21 PMC 바로가기 [Article Type] Research Article

Perinatal transmission of SARS-CoV-2 and transfer of maternal IgG/neutralizing anti-SARS-CoV-2 antibodies from mothers with asymptomatic infection during pregnancy

SARS-CoV-2의 주산기 전염 및 임신 중 무증상 감염이 있는 산모로부터 산모 IgG/중화 항-SARS-CoV-2 항체 전달

Article

Published on 2022-02-012022-09-11
Journal: Infection [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody asymptomatic infection Birth Blood blood sample conducted controls COVID-19 COVID-19 diagnosis COVID-19 pandemic during pregnancy ELISA evidenced exhibited India life majority maternal antibodies maternal antibody mother nasal Neonatal Neonate Neonates neutralization Neutralizing antibodies neutralizing antibody Perinatal Perinatal transmission positive Pregnancy pregnant women Presence preterm deliveries PRNT Prospective Study public health threat respiratory distress risk RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection subclinical infection symptomatic transfer Transmission transmission of SARS-CoV-2 Viral Viral RNA
[DOI] 10.1007/s15010-021-01650-5 PMC 바로가기 [Article Type] Article