Elevated IL-18 predicts poor prognosis in critically ill COVID-19 patients at a Brazilian hospital in 2020-21Article Published on 2022-11-012022-11-15 Journal: Future Microbiology [Category] SARS, 바이오마커, [키워드] analyzed association Biomarker Brazil clinical outcomes contribute COVID-19 COVID-19 patient Critically ill Critically ill patient cross-sectional cytokine Deceased dysregulated evaluated exhibited hospital IL-18 immune immune response Inflammation Inflammatory response Innate immunity innate immunity. intensive care laboratory data marker Older Patient patients with COVID-19 Platelet poor prognosis predict quantified significantly higher sociodemographic data with COVID-19 [DOI] 10.2217/fmb-2022-0057 PMC 바로가기
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils neutrophils. no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기
Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse modelArticle Published on 2022-10-282022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] acute respiratory syndrome Administered age anti-SARS-CoV-2 Antiviral Antiviral compound antiviral efficacy body weight Body weight loss caused Cell clinical development coronavirus coronavirus disease correlated COVID-19 demonstrated development dose dose-dependent manner effective Efficacy evaluated expression general treatment Health in vivo increased survival Inflammatory Intervention lung Lung inflammation Lung pathology mice mouse-adapted SARS-CoV-2 nucleocapsid protein pandemic patients with COVID-19 Post-infection protease pulmonary lesion quantified reduced reduced viral load RNA RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection Support suppressed survival target the SARS-CoV-2 titre treat Treatment Viral RNA was used were infected [DOI] 10.1093/jac/dkac257 PMC 바로가기
Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Affect analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody antibody assay Antibody assays antigenic antigenic structure antigens assays change changes in characterized controls convalescent individual correlation diagnostic immunoassay immunoassays immunoreactivity impairing individual Infection lack neutralization Neutralization assay Neutralizing activity Neutralizing antibodies Neutralizing antibody titer omicron Primary infection Protein quantified RBD reduced SARS-CoV-2 SARS-CoV-2-specific antibody sensitivity significantly spike statistically significant reduction subjects surrogate assay. tested the SARS-CoV-2 the Spike variant variants were used wild type wild-type wild-type strain [DOI] 10.1128/spectrum.02129-22 PMC 바로가기
Concordance of SARS-CoV-2 Antibody Results during a Period of Low PrevalenceArticle Published on 2022-10-262022-11-15 Journal: mSphere [Category] COVID19(2023년), SARS, 진단, [키워드] 95% confidence interval Abbott acute respiratory syndrome Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Antigen antigens Architect assays CDC collected combinations Concentration Concordance contributed coronavirus coronavirus disease COVID-19 Elecsy ELISA enzyme-linked immunosorbent evaluate False positivity first test Frequency IgG IgG antibodies immunoassay immunoassays Immunoglobulin individual investigated low prevalence nucleocapsid nucleocapsid protein pandemic participant Participants performed Period positive positive result Prevalence produced proportion quantified Research Result Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sequential test sera serological test seropositive specimen Spike protein spike protein. subset Support target tested the SARS-CoV-2 The United States Vaccine vaccine availability [DOI] 10.1128/msphere.00257-22 PMC 바로가기
Levels of soluble complement regulators predict severity of COVID-19 symptomsArticle Published on 2022-10-182022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] analysed Analysis approach Asymptomatic baseline level Biomarkers cascade circulating Cohort complement Control Course COVID-19 COVID-19 patients Diagnosis disease disease severity driving dysregulation Elevation Evidence Factor Factor H factor H-related proteins FIVE Healthcare systems hospitalisation Hypothesis immune activation individual lack Level majority management mass spectrometry. Mild morbidity and mortality outcome outcomes Patient plasma sample predict Protein Proteins quantified responsible SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 virus severe COVID-19 severe disease severity of COVID-19 splice subset Support Symptom variant while with COVID-19 [DOI] 10.3389/fimmu.2022.1032331 PMC 바로가기
Wastewater-based epidemiology in countries with poor wastewater treatment – Epidemiological indicator function of SARS-CoV-2 RNA in surface waters폐수 처리가 열악한 국가의 폐수 기반 역학 - 지표수에서 SARS-CoV-2 RNA의 역학 지표 기능Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adoption affected alternative analysed applied approach Bacteria Belgrade collected complex complex systems Concentration country COVID-19 Danube effort epidemiological epidemiological purposes Epidemiology Factor Factors Faecal pollution Genes Genetic human populations identify indicated methodology N1 and N2 nucleocapsid outbreak parameter physicochemical primer set primer sets Protein qualitative data quantification quantified Quantitative recipient river RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance Sava Serbia surface Surface waters Surveillance Treatment Untreated wastewaters. Volume water [DOI] 10.1016/j.scitotenv.2022.156964 PMC 바로가기 [Article Type] Article
The Efficient and Practical virus Identification System with ENhanced Sensitivity for Solids (EPISENS-S): A rapid and cost-effective SARS-CoV-2 RNA detection method for routine wastewater surveillance고형물에 대한 감도가 향상된 효율적이고 실용적인 바이러스 식별 시스템(EPISENS-S): 일상적인 폐수 감시를 위한 빠르고 비용 효율적인 SARS-CoV-2 RNA 검출 방법Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] applicability centrifugation city collected Concentration confirmed COVID-19 case COVID-19 demonstrated Detection sensitivity efficient Epidemiology evaluated examined followed by heat heat-inactivated identification Japan magnitude Mild multiplex normalized pellet Pepper mild mottle virus plant primer Primers qPCR qPCR quantification qPCR. Quantification method quantified ranged reported reverse primer reverse primers RNA concentration RNA concentrations RNA extraction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity Solid subsequent Surveillance System target targets the SARS-CoV-2 Treatment virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.157101 PMC 바로가기 [Article Type] Article
Measurement of Severe Acute Respiratory Syndrome Coronavirus 2 Antigens in Plasma of Pediatric Patients With Acute Coronavirus Disease 2019 or Multisystem Inflammatory Syndrome in Children Using an Ultrasensitive and Quantitative ImmunoassayArticle Published on 2022-10-122022-11-15 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 치료기술, [키워드] 24 hour acute COVID-19 acute respiratory syndrome Antigen antigenemia Blood blood collection blood draw CDC criteria children Concentration contribute Control coronavirus coronavirus 2 coronavirus disease correlated COVID-19 COVID-19 patient cycle threshold detection diagnostic disease severity enrolled highest hospital immunoassay Inflammatory Inpatient measurement Meso Scale Discovery MIS-C nasopharyngeal Nasopharyngeal swab negative RT-PCR Pathogenesis Patient patients Pediatric patient plasma positive quantified ranged recent respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 nucleocapsid SARS-CoV-2 RT-PCR SARS-CoV-2 spike sensitivity serology syndrome tested the patient ultrasensitive immunoassay. undetectable was collected [DOI] 10.1093/cid/ciac160 PMC 바로가기
In vitro testing of salt coating of fabrics as a potential antiviral agent in reusable face masksArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] added airway Antiviral cloth mask cloth masks collected conditions coronavirus disease COVID-19 cultures dependent on dilutions distribution Effectiveness eight epithelia epithelial evaluated Face mask Face masks H3N2 handling incubated mandatory Masks pandemic protocol quantified reduced relative remained risk Sodium chloride tested turn viral replication virus particle virus replication wearing face mask [DOI] 10.1038/s41598-022-21442-7 PMC 바로가기