Rationale and Design for the LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure (LOCHINVAR): an observational phenotyping study혈관 및 혈압(LOCHINVAR)에 대한 SARS-CoV-2 감염의 장기 효과에 대한 이론적 근거 및 설계: 관찰 표현형 연구Observational Study Published on 2022-06-012022-09-11 Journal: Open Heart [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] All participant All participants All study participants angiotensin approved baseline Biomarkers Blood blood pressure blood sample Blood samples blood vessels brachial calculated Confirmed COVID-19 infection consequence Control controls COVID-19 COVID-19 infection detect discharge Effect Elizabeth endothelial Endothelium Ethics ethics committee Evidence evidence of Hospital admission hypertension Immune status include individual Interaction International mean difference medication Myocardial infarction normal blood pressure participant Patient peer-reviewed pilot study Primary outcome protocol provided rationale recruited registration number Renin renin-angiotensin system Research Research design research design. Research Ethics Research Ethics Committee Sample Sample size SARS-CoV-2 SARS-COV-2 infection SBP stroke Study participants submitted systolic undergo university Urine Vascular vascular inflammation West with COVID-19 written Informed Consent [DOI] 10.1136/openhrt-2022-002057 PMC 바로가기 [Article Type] Observational Study
Effects of non-invasive respiratory supports on inspiratory effort in moderate-severe COVID-19 patients. A randomized physiological studyRandomized Controlled Trial Published on 2022-06-012022-10-05 Journal: European journal of internal medicine [Category] 임상, [키워드] applied arterial blood collected COVID COVID 19 COVID-19 COVID-19 patients CPAP dependent on driving early phase Effect elevated failure form HFNC Hypoxemic acute respiratory failure induced Inspiratory effort Intubated invasive Lung injury minute moderate-severe MONITOR nasal NIV Non invasive respiratory supports. Non-invasive respiratory support non-invasive ventilation Occurrence Oxygenation P-SILI PaO Patient patients physiological positive airway pressure potential risk pressure random Randomized rationale reduce reducing reduction in respiratory Respiratory failure Respiratory Support self significantly standard oxygen therapy statistically significant difference suggested the patient treat Trial Ventilation ventilator were recorded [DOI] 10.1016/j.ejim.2022.04.012 PMC 바로가기 [Article Type] Randomized Controlled Trial
Impact of COVID-19 Pandemic on the Workload of Diagnostic Radiology: A 2-Year Observational Study in a Tertiary Referral HospitalResearch article Published on 2022-06-012022-10-05 Journal: Academic radiology [Category] COVID19(2023년), SARS, 진단, [키워드] abdomen average averaged calculated Care categories change Chest comparable COVID-19 COVID-19 pandemic decrease diagnostic Diagnostic imaging epidemiological data evaluate Evaluating extreme First wave help Impact IMPROVE material Measures MRI Musculoskeletal objective pandemic Pandemics performed radiological radiology rationale reduced Referral Region restored Result subsequent Tertiary tertiary referral hospital Variation was increased was reduced workload [DOI] 10.1016/j.acra.2022.06.002 [Article Type] Research article
Risk Prediction for Acute Kidney Injury in Patients Hospitalized With COVID-19Research article Published on 2022-06-012022-10-05 Journal: Kidney Medicine [Category] 바이오마커, [키워드] 95% CI Acute kidney injury acute respiratory syndrome added age AKI baseline changes in coding Cohort cohort study cohorts comorbid condition conditions coronavirus coronavirus disease COVID-19 creatinine criteria D-dimer levels defined delta variant develop exposure ferritin Final High-sensitivity C-reactive protein hospital hospitalized patient Improving inflammatory biomarkers KDIGO Kidney injury laboratory data limitation longitudinal measure median Model model validation objective participant Patient patients patients hospitalized polymerase chain positive Potential predict prediction Predictive Predictive model rationale Result setting Vaccine validation cohort virus variants with COVID-19 [DOI] 10.1016/j.xkme.2022.100463 [Article Type] Research article
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis면역 시공간 환경의 단일 세포 전사체 프로파일링은 다균성 패혈증에서 수지상 세포 조절 프로그램을 보여줍니다Article Published on 2022-05-292022-09-11 Journal: Theranostics [Category] 치료제, [키워드] activated adopted alteration Analysis applied available data Cancer canonical CD4 cDCs characterized co-cultured comprehensive view conserved COVID-19 patients Cytometry demonstrated dendritic dendritic cell dendritic cells described determined by dissect experiment experiments expression Flow flow cytometry generate Genes heterogeneity Host immune response hyperinflammation identify IFNGR2 immune Immune cell immune cell types immune cells immunofluorescence Immunosuppression indicated inhibitory initiated Intracellular majority maturation morbidity multiplex immunofluorescence myeloid cells naïve natural killer observation organ dysfunction pathway Pathways progression promoted protein level Puncture rationale Regulatory regulatory T cells reveal scRNA-seq ScRNA-seq analysis Sepsis septic septic patients signaling pathway single-cell single-cell analysis single-cell analysis. Single-cell RNA sequencing specific type staining STAT3 subset T cell T cells tissue tissue sites Transcriptome unique upregulation [DOI] 10.7150/thno.72760 PMC 바로가기 [Article Type] Article
Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study고형 종양의 영향을 받는 환자에서 발열성 COVID-19의 발병률 및 면역학적 특징: 전향적 코호트 연구Article Published on 2022-05-142022-09-11 Journal: Journal of Translational Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected Asymptomatic case Asymptomatic cases Asymptomatic COVID-19 asymptomatic infection asymptomatic patient asymptomatic patients baseline Cancer Cancer center changes in chemokine collected COVID-19 COVID-19 in patient COVID-19 pandemic downregulation evaluated feature First wave General population IgM Immunoglobulin interleukin 6 Italy KEGG mononuclear cell mononuclear cells Nasopharyngeal swab NPs p-values pathway Pathways Patient patients PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells positive prospective cohort study rationale receptor recruited RNA SARS-CoV-2 SARS-CoV-2 IgM Sequencing Seroconversion seroconversion rate serology Signaling solid cancer subset T-cell receptor tested Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic analysis transcriptomics treated upregulated Viral Viral RNA was performed [DOI] 10.1186/s12967-022-03429-0 PMC 바로가기 [Article Type] Article
Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial간질 세포 투여에 의한 급성 호흡 곤란 증후군의 회복(REALIST): 공개 라벨 용량 증량 1상 시험에 이어 무작위, 삼중 맹검, 할당 은폐, 위약 대조 2상 시험을 위한 구조화된 연구 프로토콜Article Published on 2022-05-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 acute respiratory distress acute respiratory distress syndrome administration allocation ARDS benefit blind causes Cell cells clinical clinical trial Cohort cohort of patient cohorts of patients concealed CONSORT COVID-19 distress dose dose-escalation early stage early stages Efficacy EudraCT Good immunomodulatory incidence include Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells moderate to severe MSC MSCs multicentre NHS number Open-label outcome outlined oxygenation index patients patients with moderate Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled placebo-controlled trial Practice produced Protocol. randomised rationale receive recruited recruitment repair reported Reporting respiratory distress Respiratory distress syndrome Serious Adverse Events severe ARDS Standard stromal cell stromal cells Study protocol syndrome therapy Trial triple-blind umbilical Umbilical cord [DOI] 10.1186/s13063-022-06220-0 PMC 바로가기 [Article Type] Article
Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the “Green Pass” Policy다양한 COVID-19 백신에 대한 체액 면역 반응 다양성: "그린 패스" 정책에 대한 시사점Article Published on 2022-05-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE2 binding activities Ad26 Ad26.COV2.S age Analysis anti-RBD anti-RBD antibody titer antibody Antibody Response Antibody titer appear assumption average binding BNT162b2 booster vaccination ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine ChAdOx1 nCoV-19 vaccines concentrations country COV2.S COVID-19 COVID-19 infection COVID-19 pandemic detect Diversity elicit elicited eligibility epitope evaluated Features green Green Pass Policy heterogeneous humoral humoral immune response immune Immunity implication individual maintain mRNA mRNA-1273 Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody observé Pass peptides Policy Protein Randomly Rapid test rationale RBD RBD-ACE2 reactivity reactogenicity Receptor-binding domain reduce reopening response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike selected sera serum serum sample significantly spike Spike protein synthetic peptide the receptor-binding domain titer vaccinated individual vaccination Vaccine vaccine. virus spread [DOI] 10.3389/fimmu.2022.833085 PMC 바로가기 [Article Type] Article
The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune responseSARS-CoV-2 감염 동안 lncRNA, RNA 결합 단백질 및 바이러스 게놈 사이의 상호 작용은 RNA 대사 및 면역 반응과 관련된 조절 사건과의 강력한 연결을 보여줍니다Article Published on 2022-05-092022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyzed association BISPR Cell cellular cellular response characterized Cohort cohort of patient Combination complex component composed connection coronavirus Correlation analysis Defense defense mechanisms determine element event experimental evidence FMR1 FMR1-IT1 functional Host host cells human host cell human host cells human RNA identify immune response in silico infected cell Infection infectious agent Interaction interactions interferon interferon response intrinsic involved lncRNA long non-coding RNA mechanism metabolism MIR155HG modulate molecular ncRNAs Non-coding RNAs NRIR performed progression Protein rationale Regulation Regulatory regulatory network regulatory network. replicative reveal RNA RNA viruses RNA-binding protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load sequestering Specific Surveillance the interferon transcriptional transcriptomic triggered USP30 USP30-AS1 Viral viral genome viral infections viral RNA genome [DOI] 10.7150/thno.73268 PMC 바로가기 [Article Type] Article
Personality, gender, and age resilience to the mental health effects of COVID-19Research article Published on 2022-05-012022-10-05 Journal: Social science & medicine (1982) [Category] 유전자 메커니즘, [키워드] adaptive affected age assist can be used Characteristics Cohort COVID-19 COVID-19 pandemic Critical Effect event extroversion fixed Gender help identify Impact increase in individual individuals knowledge loneliness Longitudinal data Mental mental health objective occur Other pandemic Personality promote Psychological Psychological distress public health rationale Resilience response Result Support Symptom traits understanding worsening young adults [DOI] 10.1016/j.socscimed.2022.114884 [Article Type] Research article