Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2Article Published on 2022-10-212022-11-15 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antivirals Combination cysteine cysteines effective epitope human host inhibit Interaction iterative methodology N-terminal novel peptide peptides potent Protein RBD reaction receptor Receptor binding domain SARS-CoV-2 Selection spike the SARS-CoV-2 the Spike Vero E6 cell virus were used [DOI] 10.1021/acschembio.2c00565 PMC 바로가기
Comparative effectiveness of neutralising monoclonal antibodies in high risk COVID-19 patients: a Bayesian network meta-analysisArticle Published on 2022-10-202022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), meta-analysis, SARS, 변종, 진단, [키워드] absolute reduction article baseline Bayesian comparable Comparative COVID-19 Effect effective Effectiveness Efficacy Evidence expected generalisability healthcare high risk hospitalisation ICU admission identify individual infected individual infected with SARS-CoV-2 invasive ventilation moderate monoclonal antibody Mortality network Network meta-analysis neutralising outcome Pairwise comparison patient population patients patients treated Placebo predict Rate RCT reaction reduce mortality reducing reduction in relative risk risk reduction serious AE severe COVID-19 statistically significant reduction systematic review therapy treatment effect vaccination variant [DOI] 10.1038/s41598-022-22431-6 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination StudiesArticle Published on 2022-10-062022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] accompanied ADMET anti-coronavirus activity anti-SARS-CoV-2 anti-SARS-CoV-2 therapeutics Anti-viral antiviral activity approach binding candidate Combination Community Compound COVID-19 drug combination drug combination protocol effective highlight highly pathogenic human coronavirus in silico inhibit investigated MD simulation MERS-CoV moiety molecular molecular dynamic simulation (MDS) pharmacophores protocol protocols reaction Research SARS-CoV-2 spirooxindole. synergistic synthesis tested were assessed [DOI] 10.3390/ijms231911861 PMC 바로가기
A Cross-Sectional Study of Untoward Reactions Following Homologous and Heterologous COVID-19 Booster Immunizations in Recipients Seventeen Years of Age and OlderArticle Published on 2022-10-012022-11-16 Journal: Journal of community health [Category] COVID19(2023년), SARS, 변종, [키워드] Active surveillance Adverse adverse event adverse events Adverse reaction Adverse reactions B.1.1.529 B.1.617.2 booster booster dose Comirnaty COVID-19 COVID-19 booster vaccination COVID-19 vaccination Delta described dose enrolled events fatigue female Fever Frequency injection Italy lack Local malaise Mild moderate Moderna mRNA mRNA vaccines occurred Occurrence Older omicron outcome Pain participant Pfizer/BioNTech questionnaire reaction recipient reported Safety significantly Spikevax. stratified Surveillance vaccination Vaccine variants vomiting was used Year [DOI] 10.1007/s10900-022-01112-5 PMC 바로가기
Treatment retention, return to use, and recovery support following COVID-19 relaxation of methadone take-home dosing in two rural opioid treatment programs: A mixed methods analysisResearch article Published on 2022-10-012022-10-05 Journal: Journal of substance abuse treatment [Category] 치료법, [키워드] Abuse Analysis association change clinically COVID-19 dose doses Effect EHR employment expected feasible FIVE Health increase in individual less Medication for opioid use disorder Methadone objective opioid Opioid treatment OTP Patient patients positive positive result Probability Program promoted public health Qualitative qualitative analysis Quantitative reaction reduced regimens Regression model Result rural service substance Support supported Travel Treatment triggers Urine [DOI] 10.1016/j.jsat.2022.108801 [Article Type] Research article
Diagnostic efficiency of RT-LAMP integrated CRISPR-Cas technique for COVID-19: A systematic review and meta-analysisArticle Published on 2022-10-012022-11-15 Journal: Pathogens and global health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Accuracy applicability article calculated Care chain conducted confidence interval COVID-19 COVID-19 diagnosis COVID-19 pandemic CRISPR-Ca CRISPR-Cas database Diagnosis diagnostic Diagnostic method Efficiency eligibility criteria epidemiological equipment False-positive faster feasible forest plot isothermal amplification limit management Meta-analysis Meta-analysis. molecular N gene Precision problem QUADAS-2 Quantitative reaction Region regions resource reverse transcription RT-LAMP RT-qPCR SARS-CoV-2 sensitivity specificity systematic review Transcription USA was performed with COVID-19 [DOI] 10.1080/20477724.2022.2035625 PMC 바로가기
Safety and efficacy of COVID-19 vaccines in children and adolescents: A systematic review of randomized controlled trials소아 및 청소년에 대한 COVID-19 백신의 안전성 및 효능: 무작위 대조 시험의 체계적인 검토Review Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 임상, [키워드] Abstract age Analysis bias risk children Children and adolescents Chinese clinical clinical trial Cochrane Library code common adverse event common adverse events coronavirus coronavirus disease cough COVID-19 COVID-19 infection COVID-19 vaccine COVID-19 vaccines data extraction Efficacy evaluated fatigue Fever groups headache ICTRP immunization Injection-site pain investigated Local Messenger RNA Microsoft Excel Mild mild to moderate moderate MOST mRNA mRNA vaccine mRNA vaccines muscle pain Pain participant pediatric Placebo profile Randomized controlled trial Randomized controlled trials RCT RCTs reaction Reactions registry reported Safety searched Serious Adverse Events Seven stratified suggested systematic review systematic review. systemic adverse event the vaccine title Trial vaccination Vaccine was used Web of Science website were used [DOI] 10.1002/jmv.27940 PMC 바로가기 [Article Type] Review
Patients with previous immediate hypersensitivity reactions to polyethylene glycol can safely receive the BNT162b2 mRNA COVID-19 vaccineArticle Published on 2022-10-012022-11-15 Journal: Internal medicine journal [Category] 진단, [키워드] allergic anaphylaxis BNT162b2 mRNA Community COVID-19 COVID-19 vaccine doses eight Evidence first dose glycol hospital hypersensitivity hypersensitivity reaction Mild molecular weight New offered Patient Pfizer reaction receive receiving Record second dose thought Vaccine Vaccines [DOI] 10.1111/imj.15821 PMC 바로가기
Considerations for the selection of tests for SARS-CoV-2 molecular diagnosticsArticle Published on 2022-10-012022-11-15 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] Accuracy authorization chain clinical country Course COVID-19 criteria detect develop diagnostic Diagnostic performance diagnostic test diagnostics drug evaluated food gold standard good manufacturing practice Guidance independent Infection information Laboratory lack molecular molecular test Mutation Novel coronavirus outbreak pandemic proportion Quality control reaction real-time RT-PCR Region regions regulatory authority required respiratory SARS-CoV-2 SARS-CoV-2 test selected Spread target gene Test Test selection. variable [DOI] 10.1007/s11033-022-07455-5 PMC 바로가기