Receptor binding – Page 2 – Communicable Diseases Research

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod

Article

Published on 2022-09-012022-11-15
Journal: Journal of neurology, neurosurgery, and psychiatry
[Category] COVID19(2023년), SARS, 진단,

Preserved recognition of Omicron spike following COVID-19 messenger RNA vaccination in pregnancy

임신 중 COVID-19 메신저 RNA 백신 접종 후 오미크론 스파이크의 보존된 인식

Article

Published on 2022-09-012022-09-11
Journal: American journal of obstetrics and gynecology
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] administration analyzed antibodies antibody attenuate binding center Complete Control COVID-19 COVID-19 vaccine COVID-19 vaccines disease disease control disease course disease severity during pregnancy Efficacy Evolution of SARS-CoV-2 Fc receptor Fc receptors Fcγ receptor full dose regimen Immunoglobulin immunoglobulin M Infection Luminex assay Messenger RNA Moderna mRNA mRNA vaccine mRNA-1273 neutralization Neutralizing activity Neutralizing antibodies obstetrics omicron Omicron variant organization Pfizer/BioNTech Pregnancy pregnant women preserved prevention PROTECT raised receiving receptor Receptor binding Receptor binding domain reduce reduced remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe disease Spike-specific antibody These data vaccinated individuals vaccination Vaccine vaccine efficacy vaccine-induced antibodies vaccine-induced antibody Vaccine-induced immunity variant variants variants of concern variants of concern.
[DOI] 10.1016/j.ajog.2022.04.009 PMC 바로가기 [Article Type] Article

Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV-2 of different lineages

Article

Published on 2022-09-012022-11-16
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 변종,

[키워드] accumulated African amino acid substitution analysis AY.1 B.1.617.2 B.1.621 binding binding interaction China Combination Complexes COVID-19 Delta docking domain Effect exhibited Factors Genetic hACE2 hACE2. Host human Angiotensin-converting enzyme Interaction investigated Latin Lineage missense variant Missense variants MM/GBSA molecular docking molecular docking analysis molecular dynamics Molecular dynamics simulation MOST Mutation mutations non-Finnish European omicron Population populations predict prevalent protein stability rate of infection RBD Receptor binding risk SARS-CoV-2 SARS-CoV-2 RBD South Asian spike glycoprotein suffered the SARS-CoV-2 Transmissibility variant variants variants of concern viral variant virus was performed Wuhan
[DOI] 10.1016/j.compbiomed.2022.105903 PMC 바로가기

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

Article

Published on 2022-08-292022-11-15
Journal: PLoS ONE
[Category] SARS, 변종, 치료제,

[키워드] activated Analysis Beta Brain Cell challenge COVID-19 COVID-19 pandemic Delta delta variant Delta VOC Differential gene expression disease dose engage ENhance evaluate experiment Gene Expression highest histopathological host response IFN-γ in silico in vivo induce infiltration Inflammation Inflammatory response interferon response K18-hACE2 mice lung lung tissue magnitude mice nasal no significant difference observation Pathogenesis pathology Pneumonia pro-inflammatory cytokine qRT-PCR analysis Receptor binding RNA-sequencing SARS-CoV-2 strain Strains suggested T-cell TCR Total Transmissibility unique Vaccines variants of concern Viral RNA VoC was performed
[DOI] 10.1371/journal.pone.0273430 PMC 바로가기

Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape

Omicron SARS-CoV-2 돌연변이는 스파이크 업-RBD 형태를 안정화하고 비-RBM-결합 단일클론 항체 탈출을 유도합니다

Article

Published on 2022-08-242022-09-11
Journal: Nature Communications
[Category] SARS, 변종, 유전자 메커니즘, 진단,

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

SARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다

Article

Published on 2022-08-242022-09-11
Journal: Journal of Virology
[Category] SARS, 변종, 진단,

[키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody. omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs
[DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article

Broadly neutralizing antibodies target the coronavirus fusion peptide

광범위 중화 항체는 코로나바이러스 융합 펩티드를 표적으로 한다

Article

Published on 2022-08-122022-09-12
Journal: Science (New York, N.y.)
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Insight into molecular characteristics of SARS-CoV-2 spike protein following D614G point mutation, a molecular dynamics study

D614G 점 돌연변이에 따른 SARS-CoV-2 스파이크 단백질의 분자 특성에 대한 통찰력, 분자 역학 연구

Article

Published on 2022-08-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 변종,

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

BA.2.12.1, BA.4 및 BA.5는 Omicron 감염에 의해 유발된 항체를 탈출합니다.

Comparative Study

Published on 2022-08-012022-09-11
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody bebtelovimab binding affinities binding affinity booster cilgavimab clone comparison coronavirus cross-reactive distribution Efficiency elicited enzyme epitope Epitopes escape mutation evade exhibiting humoral Humoral immunity immune memory individual induce Infection L452R Lineage mechanism Mutation mutations neutralization neutralize Neutralizing antibodies neutralizing antibody omicron Omicron variants plasma profile recall receptor Receptor binding Receptor-binding domain referred to respiratory resulting sarbecovirus SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies Spike mutant spike mutants Spike protein Spike proteins the receptor-binding domain therapeutic Transmissibility vaccination Vaccine variant variants Viral viral spike protein wild-type WT SARS-CoV-2
[DOI] 10.1038/s41586-022-04980-y PMC 바로가기 [Article Type] Comparative Study

Vaccine based on folded receptor binding domain-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variants

SARS-CoV-2 변이체에 대한 살균 면역을 유도할 수 있는 접힌 수용체 결합 도메인-PreS 융합 단백질 기반 백신

Article

Published on 2022-08-012022-09-11
Journal: Allergy
[Category] COVID19(2023년), SARS, 변종, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response Antigen C-terminus carrier cellular combination vaccine construction convalescent coronavirus COVID-19 COVID-19 pandemic fused fusion protein Genetic genotypes HBV healthy subject healthy subjects hepatitis B Hepatitis B virus human cell human cells IgG IgG antibodies IgG antibody IgG response Immunity immunized in vitro in vivo induce inhibited Interaction maintenance median mucosal secretions Neutralizing Neutralizing antibodies neutralizing antibody neutralizing titers Omicron variant pandemic Protein random Random sample RBD RBD-specific IgG RBD-specific IgG response receptor ACE2 Receptor binding Receptor-binding domain recombinant fusion protein Registered replicate respiratory response responsible robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies specific IgG antibodies spike Spike protein sterilizing immunity subject subjects subunit Subunit vaccine surface antigen sustained Vaccine vaccine. Viral viral replication virus entry virus-neutralizing VNT
[DOI] 10.1111/all.15305 PMC 바로가기 [Article Type] Article