Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France장기간 ACE 억제제/ARB 사용은 중증 COVID-19 환자의 중증 신장 기능 장애 및 급성 신장 손상과 관련이 있습니다: 프랑스 북동부의 추천 센터 코호트 결과Article Published on 2020-12-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 바이오마커, [키워드] 95% CI 95% confidence interval ACE ACEi ACEi/ARB acute kidney Acute kidney injury Acute respiratory failure Analysis angiotensin angiotensin receptor blocker Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor ARB association biochemical Biomarker center characteristic consecutive patient consecutive patients converting enzyme inhibitor coronavirus disease Coronavirus disease 2019 COVID-19 creatinine daily dose diagnosed disease Enzyme inhibitor evaluated France heart increase in increased risk independent predictors inflammatory reaction influence kidney Lisinopril liver dysfunction liver dysfunctions Logistic regression analysis longitudinal cohort study lung marker multivariable nitrogen Occurrence Odds ratio outcomes Patient patients performed phosphorus predict predictor receiver operating characteristic receptor receptor blocker Referral repeated measures Respiratory failure Result retrospective risk SARS-CoV-2 severe coronavirus disease severe COVID-19 severity treated urea urea nitrogen were assessed [DOI] 10.1093/cid/ciaa677 PMC 바로가기 [Article Type] Article
Neprilysin expression and functions in development, ageing and disease발달, 노화 및 질병에서의 네프릴리신 발현 및 기능Review Published on 2020-12-012022-08-31 Journal: Mechanisms of ageing and development [Category] MERS, SARS, 바이오마커, [키워드] Ageing AICD Alzheimer's disease Alzheimer’s disease amyloid-degrading enzyme angiotensin angiotensin receptor blocker approved Aβ peptide brain development CALLA Cancer CD10 cell proliferation changes in cognitive cognitive behaviour Compound cortex COVID-19 pathogenesis diabetes disease EGCG embryogenesis endopeptidase endopeptidase 24.11 enkephalinase enzyme Epigenetic epigenetic regulation expression foetal development function functions green tea HDACs heart failure hippocampus hypertension hypoxia immune response implicated inhibitor Intensive kidney membrane-bound memory NEP inhibitors olfactory bulbs neprilysin obesity olfactory Organisms Pathogenesis pathological conditions Pathologies peptide pharmacological treatment pharmacological treatments physiological functions prenatal prenatal hypoxia Prevent Preventive medicine Prostate cancer proteolytic receptor blocker Regulation Research Sacubitril striatum striatum. substrate substrates suggested therapeutic target Treatment type-2 diabetes upregulating valsartan [DOI] 10.1016/j.mad.2020.111363 PMC 바로가기 [Article Type] Review