Validation Study of a Direct Real-Time PCR Protocol for Detection of Monkeypox VirusArticle Published on 2022-11-012022-11-15 Journal: The Journal of molecular diagnostics : JMD [Category] 치료기술, [키워드] Accuracy approach coronavirus disease COVID-19 described detection develop Direct eliminating imperative IMPROVE International Laboratory Laboratory testing Monkeypox nucleic acid extraction outbreak pandemic PCR protocol public health emergency Real-time PCR reducing sensitivity The United States validation virus World Health Organization [DOI] 10.1016/j.jmoldx.2022.09.001 PMC 바로가기
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemicArticle Published on 2022-11-012022-11-16 Journal: Immunology [Category] SARS, 변종, [키워드] Asymptomatic breadth cellular Clinical severity COVID-19 COVID-19 pandemic Critical Cross-immunity cytokine Cytokine storm detrimental disease disease severity effort events Evidence feature highlighting immune response Immunopathogenesis Infection Innate immunity pathogen pathogenic processes Protective protective immunity protective immunity. protective role provided public health reducing resulting T-cell immunity the SARS-CoV-2 therapeutic approaches tissue injury Vaccine Viral variants [DOI] 10.1111/imm.13564 PMC 바로가기
A computational approach to biological pathogenicityArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] 바이오마커, [키워드] Accuracy adverse impact approach assessment Biochemistry Biomarkers clinical trial COVID-19 death Digital Digital genomic signature DNA DNA sequence energy event feature genomic Gibbs energy h-distance. Health Host humans hybridization machine machine learning machine learning model methodology microbe mitigate new strain oligonucleotide Other pandemic pathogen pathogenic Pathogenic relationship pathogenicity Pathogens/nonpathogens Perspective predict Quality reducing sensitivity Sensitivity and specificity Sickness specificity structural property [DOI] 10.1007/s00438-022-01951-w PMC 바로가기
Challenges of vaccination and herd immunity in COVID-19 and management strategiesArticle Published on 2022-11-012022-11-16 Journal: The clinical respiratory journal [Category] SARS, 변종, [키워드] acute respiratory syndrome caused challenge contagious coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 vaccination COVID-19 vaccine Critical death Defense effective eligible help herd immunity Hospitalization Immunity management mutant Outbreaks prevention PROTECT reduce reducing risk SARS-CoV-2 SARS-CoV-2 variant severe disease Spread susceptible the disease vaccination vaccination. variants viral disease virus [DOI] 10.1111/crj.13543 PMC 바로가기
Smartphone-Based Electrochemical Immunoassay for Point-of-Care Detection of SARS-CoV-2 Nucleocapsid ProteinArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibody bovine calculated coated with Concentration detection detection efficiency diagnose Diagnosis effective electron transfer facilitate immunoassay lack less limit of detection linear N protein nucleocapsid protein offer point-of-care provided R 2 reduced reducing reported resulting SARS-CoV-2 SARS-CoV-2 N protein serological serum albumin the SARS-CoV-2 transmitted virus transmission [DOI] 10.1021/acs.analchem.2c03606 PMC 바로가기
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기
Effectiveness, Policy, and User Acceptance of COVID-19 Contact-Tracing Apps in the Post-COVID-19 Pandemic Era: Experience and Comparative StudyArticle Published on 2022-10-272022-11-16 Journal: JMIR Public Health and Surveillance [Category] 변종, 치료기술, [키워드] acceptance Accuracy addition Bluetooth collected Comparative Contact Contact tracing contact-tracing app country COVID-19 COVID-19 infections CTA CTAs detection rate digital contact tracing Effectiveness example experience Google Google Scholar Guidance had no individual Infection information investigated knowledge lack mobile phone. National pandemic era Policy Prevent problem problems provided reduce reducing second selected separated significantly subsequent Transmission user variants variety virus propagation website [DOI] 10.2196/40233 PMC 바로가기
Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum SamplesArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] 바이오마커, 변종, 치료제, [키워드] Accuracy applied approaches clinical sample clinician Complete COVID-19 pandemic Culture deaths described detect Diagnosis diagnostic test disease drug drug resistance drug susceptibility drugs effective Establishing evaluate evaluated faster genetic marker Genetic variant genetics genomic variant helping identification identify infecting Infectious disease information initial Initially molecular molecular test Mutation Mycobacterium Mycobacterium tuberculosis negatively affected Next-generation sequencing NGS phenotypic Phylogenetic phylogenetically Phylogeny protocol Rapid reducing reliability reported resistance responsible resulting Sample sequenced Sequencing sputum Sputum sample sputum samples Stage strain targeted sequencing TB patient the WHO Treatment Tuberculosis tuberculosis. was used WGS WHO [DOI] 10.1128/spectrum.01252-22 PMC 바로가기
Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 OutpatientsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acting acute respiratory syndrome added Administered administration Amplicon sequencing analyses Analysis antibody Antiviral antiviral property antiviral strategy applied Bacteria benefit Care chills collected Combined coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients detectable Diagnosis diarrhea double-blind dried blood spot eligible evaluated Fever Health hospital Hospitalization infected with SARS-CoV-2 Lactobacillaceae lactobacilli Microbiome modulation multifactorial nasopharyngeal viral load nose-throat swab online questionnaire Outpatient Pain Patient per-protocol analysis Placebo placebo-controlled trial positive potential mechanism practitioners qPCR quantitative PCR Randomized reduce reducing reported reported symptom respiratory tract infection respiratory viral disease SARS-CoV-2 selected sequence severity significantly spray strain Symptom symptom resolution the patient the placebo group therapy Throat throat spray. Treatment Trial trials upper respiratory tract Vaccines variant Viral diseases viral infection Viral load was performed [DOI] 10.1128/spectrum.01682-22 PMC 바로가기