Changes in handwashing and hygiene product usage patterns in Korea before and after the outbreak of COVID-19Research Published on 2021-07-032022-11-01 Journal: Environmental Sciences Europe [Category] COVID-19, [키워드] acute respiratory syndrome Bar soap caused change Coronavirus-2 COVID-19 COVID-19 infections COVID-19 outbreak disease duration of use Effectiveness Encouraging evaluate evaluated facial Frequency global pandemic hand hygiene hand sanitizer handwashing Health hygiene hygiene product Intervention Korea Liquid hand soap Mask outbreak potential risk public health questionnaire recommendation reducing Regulatory Authorities Result SARS-CoV-2 significantly social distancing spread of COVID-19 supplementary material Support the disease World Health Organization [DOI] 10.1186/s12302-021-00517-8 PMC 바로가기 [Article Type] Research
Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World DataCOVID-19 임상 시험의 약물: 체외 분석 및 실제 데이터를 사용하여 운반체 매개 약물-약물 상호작용 예측Article Published on 2021-07-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 임상, 치료제, [키워드] accelerated ADRS Adverse drug reaction Adverse drug reactions Chloroquine clinical clinical investigation clinical study clinical trial clinical trials clinically concentrations concomitant medications coronavirus disease Coronavirus disease 2019 COVID-19 criteria database determine drug drug-drug interaction Efficacy Electronic health records expressing Future HEK293 cell HEK293 cells Hydroxychloroquine inhibit membrane vesicle Numerous Older patients with COVID-19 predict predicted real-world data Regulatory Authorities regulatory authority representing risk Risk assessment Sildenafil small molecule small molecule drug target targets Treatment [DOI] 10.1002/cpt.2236 PMC 바로가기 [Article Type] Article
IABS/CEPI platform technology webinar: Is it possible to reduce the vaccine development time?IABS/CEPI 플랫폼 기술 웨비나: 백신 개발 시간 단축이 가능한가?Article Published on 2021-06-012022-08-31 Journal: Biologicals : journal of the International Associa [Category] MERS, SARS, 변종, 신약개발, [키워드] Alliance backbone Biological Biological Standardization Coalition component COVID-19 COVID-19 vaccine development disease Diseases Emerging infectious diseases faster Genetic Infectious diseases Innovation input joint meeting organized pandemic pathogen Pathogens platform Platform technology protein sequences rapid response reduce Regulatory Regulatory Authorities regulatory authority SARS-CoV-2 the vaccine Vaccine development variants of SARS-CoV-2 [DOI] 10.1016/j.biologicals.2021.04.005 PMC 바로가기 [Article Type] Article
JAK-STAT Pathway Inhibition and their Implications in COVID-19 TherapyJAK-STAT 경로 억제 및 COVID-19 치료에 미치는 영향Review Published on 2021-06-012022-09-11 Journal: Postgraduate medicine [Category] 유전자 메커니즘, 치료법, [키워드] 3CL pro activated Activation adverse effects B cell Baricitinib clinical trial contrary COVID-19 COVID-19 patients COVID-19 therapy cytokine cytokine receptor cytokine signaling Cytokine storm dendritic cell dendritic cells determine Disease progression disease severity Efficacy effort endothelial cells envelope protein envelope proteins excessive inflammation Host hosts immune response immune responses implicated incidence of COVID-19 increase Inflammation Inflammatory marker inflammatory markers Inflammatory mediators inhibition inhibitor inhibitors Jak Jak-STAT JAK/STAT JAK/STAT pathway JAK/STAT signaling janus Janus kinase Lymphocytes macrophages mechanism membrane molecular Monocytes natural killer cell Natural killer cells nucleocapsid nucleus Phosphorylation Pneumocytes progression promote protease Proteases Protein recruitment reduce Regulatory Authorities regulatory authority required ruxolitinib SARS-CoV-2 SARS-COV-2 infection severity signaling cascade signaling cascades STAT STATs structural protein structural proteins supported suppressor suppressors survival T cell the disease Therapeutic strategies therapeutic strategy Tofacitinib translate Trigger tyrosine [DOI] 10.1080/00325481.2020.1855921 PMC 바로가기 [Article Type] Review
A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2020약리학의 1년: 2020년 미국 식품의약국(FDA) 승인 신약Review Published on 2021-04-162022-08-31 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] MERS, 신약개발, [키워드] affected antibodies Antisense oligonucleotides approvals approved approved drug COVID-19 pandemic Decline declines disease drug Drug administration Drug discovery FDA First-in-class First-in-indication followed by food highest include indication Innovation mechanism mechanism of action MOST NEUROLOGY New drugs oncology Regulatory Authorities RNA small molecule Small molecules These data treat Treatment tropical Tropical Diseases US Food and Drug Administration while [DOI] 10.1007/s00210-021-02085-3 PMC 바로가기 [Article Type] Review
mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested ApproachCOVID-19 질병 및 보고된 알레르기 반응을 예방하기 위한 mRNA 백신: 현재 증거 및 제안된 접근 방식Review Published on 2021-04-012022-09-11 Journal: The journal of allergy and clinical immunology. In [Category] 임상, [키워드] administer allergic allergic reaction Allergic reactions allergy American Americans anaphylaxis authorization Care CDC center clinics conjunction Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine current develop disease control drug effective Emergency Emergency use authorization Epidemiology EUA FDA first dose food global pandemic glycol Guidance guidelines Hope identify individual information Moderna mRNA offer Pfizer-BioNTech Phase 3 trials polyethylene Polyethylene glycol Polysorbate prevention public health raised reaction reassurance receive recommendation regulatory agencies Regulatory Authorities risk stratification staff Support the vaccine U.S. Food and Drug Administration vaccination Vaccine widespread [DOI] 10.1016/j.jaip.2020.12.047 PMC 바로가기 [Article Type] Review
The time is now: role of pragmatic clinical trials in guiding response to global pandemics지금이 바로 지금입니다: 세계적인 유행병에 대한 대응을 안내하는 실용적인 임상 시험의 역할Review Published on 2021-03-242022-09-10 Journal: Trials [Category] 신약개발, 임상, [키워드] Adaptive trials design alternative blunt clinical evidence clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Efficacy Electronic health records-embedded research Epidemic Evidence evidence of facilitate generate highlight implementation inefficient morbidity morbidity and mortality pandemic Pandemics platform Pragmatic Pragmatic clinical trials randomized clinical trial Regulatory Authorities regulatory authority Research several limitation several limitations subsequent Treatment widespread [DOI] 10.1186/s13063-021-05165-0 PMC 바로가기 [Article Type] Review
Effect of COVID-19 on acute treatment of ST-segment elevation and Non-ST-segment elevation acute coronary syndrome in northwestern SwitzerlandResearch article Published on 2021-02-012022-10-05 Journal: IJC Heart & Vasculature [Category] 치료법, [키워드] acute coronary syndromes Analysis chest pain coronary syndrome COVID-19 COVID-19 outbreak declined defined Effect Ejection fraction evaluated Health care system hospital Intervention LVEF median Non-ST-segment acute coronary syndrome (NSTE-ACS) Non-ST-segment myocardial infarction outbreak pandemic Patient patients Percutaneous coronary intervention performed presenting reduction Region Regulatory Authorities remained Result ST-segment elevation myocardial infarction Switzerland time Treatment ventricular Virus Disease while [DOI] 10.1016/j.ijcha.2020.100686 [Article Type] Research article
Multilevel Engagements of Pharmacists During the COVID-19 Pandemic: The Way ForwardPublic Health Published on 2020-12-082022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Active surveillance activity acute respiratory syndrome adaptive caused China Clinical pharmacist clinical trials Community Community pharmacist contagious coronavirus coronavirus disease counseling COVID-19 COVID-19 pandemic Drug evaluation effective Engagement Forward Guidance Health healthcare healthcare facility Healthcare professional Healthcare system help hospital increase in industrial pharmacist Infection prevention information International Intervention life-threatening manuscript Novel coronavirus offered pandemic Patient Personal protective equipment Pharmacist Pharmacy pharmacy services public health public health emergency Regulatory Authorities reported resulting SARS-CoV-2 virus WHO World Health Organization [DOI] 10.3389/fpubh.2020.561924 PMC 바로가기 [Article Type] Public Health
Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic OutbreakReview Published on 2020-09-222022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] approach approved assessments COVID-19 Cushing’s syndrome cushing’s syndrome de novo developmental disease Diseases drug Drug discovery drug personalisation drug repositioning Efficacy and safety Future HIV HIV infection margin New novel novel diseases orphan diseases outbreak pandemic personalised Regulatory Authorities repositioning Research risk treat Treatment [DOI] 10.3390/v12091058 PMC 바로가기 [Article Type] Review